Abstract
The likely mechanisms of action of narrow-band ultraviolet B (NB-UVB) in atopic dermatitis are several. We attempted, in a 12 patient prospective intraindividually controlled study, to determine whether the effect of NB-UVB in atopic dermatitis is primarily through systemic or local effects. Change in observer-assessed severity of patches of dermatitis covered during each whole-body NB-UVB treatment was compared with change in uncovered neighbouring patches. We found great variation between patients in responses. Only in two (of 12) patients was there a large difference between directly exposed and covered patch dermatitis severity. We suspect that the balance of local and systemic effects important in determining response to NB-UVB in atopic dermatitis varies from patient to patient. This study did not conclusively answer our original question, but did show that in some patients localized effects of NB-UVB are important.
| Original language | English |
|---|---|
| Pages (from-to) | 333-335 |
| Number of pages | 3 |
| Journal | Photodermatology, Photoimmunology & Photomedicine |
| Volume | 21 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2005 |
Keywords
- Prospective Studies
- Dermatitis, Atopic
- Ultraviolet Therapy
- Humans
- Case-Control Studies
- Time Factors
- Male
- Female
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