DOLORisk

study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain

Mathilde M. V. Pascal (Lead / Corresponding author), Andreas C. Themistocleous, Ralf Baron, Andreas Binder, Didier Bouhassira, Geert Crombez, Nanna B. Finnerup, Janne Gierthmühlen, Yelena Granovsky, Leif Groop, Harry L. Hebert, Troels S. Jensen, Kristinn Johnsen, Mark I. McCarthy, Weihua Meng, Colin N. A. Palmer, Andrew S. C. Rice, Jordi Serra, Romà Solà, David Yarnitsky & 3 others Blair H. Smith, Nadine Attal, David L. H. Bennett

Research output: Contribution to journalArticle

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Abstract

Background: Neuropathic pain is an increasingly prevalent condition and has a major impact on health and quality of life. However, the risk factors for the development and maintenance of neuropathic pain are poorly understood. Clinical, genetic and psychosocial factors all contribute to chronic pain, but their interactions have not been studied in large cohorts. The DOLORisk study aims to study these factors.

Protocol: Multicentre cross-sectional and longitudinal cohorts covering the main causes leading to neuropathic pain (e.g. diabetes, surgery, chemotherapy, traumatic injury), as well as rare conditions, follow a common protocol for phenotyping of the participants. This core protocol correlates answers given by the participants on a set of questionnaires with the results of their genetic analyses. A smaller number of participants undergo deeper phenotyping procedures, including neurological examination, nerve conduction studies, threshold tracking, quantitative sensory testing, conditioned pain modulation and electroencephalography.
Ethics and dissemination: All studies have been approved by their regional ethics committees as required by national law. Results are disseminated through the DOLORisk website, scientific meetings, open-access publications, and in partnership with patient organisations.

Strengths and limitations:
- Large cohorts covering many possible triggers for neuropathic pain
- Multi-disciplinary approach to study the interaction of clinical, psychosocial and genetic risk factors
- High comparability of the data across centres thanks to harmonised protocols
- One limitation is that the length of the questionnaires might reduce the response rate and quality of responses of participants
Original languageEnglish
Article number63
Pages (from-to)1-16
Number of pages16
JournalWellcome Open Research
Volume3
DOIs
Publication statusPublished - 29 May 2018

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Neuralgia
Observational Studies
Network protocols
Ethics Committees
Chemotherapy
Neural Conduction
Neurologic Examination
Medical problems
Electroencephalography
Ethics
Chronic Pain
Surgery
Publications
Websites
Maintenance
Quality of Life
Modulation
Health
Organizations
Psychology

Keywords

  • pain
  • neuropathy
  • neuropathic pain
  • diabetes
  • nerve injury
  • risk factors
  • protocol

Cite this

Pascal, M. M. V., Themistocleous, A. C., Baron, R., Binder, A., Bouhassira, D., Crombez, G., ... Bennett, D. L. H. (2018). DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain. Wellcome Open Research, 3, 1-16. [63]. https://doi.org/10.12688/wellcomeopenres.14576.1
Pascal, Mathilde M. V. ; Themistocleous, Andreas C. ; Baron, Ralf ; Binder, Andreas ; Bouhassira, Didier ; Crombez, Geert ; Finnerup, Nanna B. ; Gierthmühlen, Janne ; Granovsky, Yelena ; Groop, Leif ; Hebert, Harry L. ; Jensen, Troels S. ; Johnsen, Kristinn ; McCarthy, Mark I. ; Meng, Weihua ; Palmer, Colin N. A. ; Rice, Andrew S. C. ; Serra, Jordi ; Solà, Romà ; Yarnitsky, David ; Smith, Blair H. ; Attal, Nadine ; Bennett, David L. H. / DOLORisk : study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain. In: Wellcome Open Research. 2018 ; Vol. 3. pp. 1-16.
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abstract = "Background: Neuropathic pain is an increasingly prevalent condition and has a major impact on health and quality of life. However, the risk factors for the development and maintenance of neuropathic pain are poorly understood. Clinical, genetic and psychosocial factors all contribute to chronic pain, but their interactions have not been studied in large cohorts. The DOLORisk study aims to study these factors.Protocol: Multicentre cross-sectional and longitudinal cohorts covering the main causes leading to neuropathic pain (e.g. diabetes, surgery, chemotherapy, traumatic injury), as well as rare conditions, follow a common protocol for phenotyping of the participants. This core protocol correlates answers given by the participants on a set of questionnaires with the results of their genetic analyses. A smaller number of participants undergo deeper phenotyping procedures, including neurological examination, nerve conduction studies, threshold tracking, quantitative sensory testing, conditioned pain modulation and electroencephalography.Ethics and dissemination: All studies have been approved by their regional ethics committees as required by national law. Results are disseminated through the DOLORisk website, scientific meetings, open-access publications, and in partnership with patient organisations.Strengths and limitations:- Large cohorts covering many possible triggers for neuropathic pain- Multi-disciplinary approach to study the interaction of clinical, psychosocial and genetic risk factors- High comparability of the data across centres thanks to harmonised protocols- One limitation is that the length of the questionnaires might reduce the response rate and quality of responses of participants",
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author = "Pascal, {Mathilde M. V.} and Themistocleous, {Andreas C.} and Ralf Baron and Andreas Binder and Didier Bouhassira and Geert Crombez and Finnerup, {Nanna B.} and Janne Gierthm{\"u}hlen and Yelena Granovsky and Leif Groop and Hebert, {Harry L.} and Jensen, {Troels S.} and Kristinn Johnsen and McCarthy, {Mark I.} and Weihua Meng and Palmer, {Colin N. A.} and Rice, {Andrew S. C.} and Jordi Serra and Rom{\`a} Sol{\`a} and David Yarnitsky and Smith, {Blair H.} and Nadine Attal and Bennett, {David L. H.}",
note = "This work was supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 633491 (DOLORisk), and the International Diabetic Neuropathy Consortium (IDNC) research programme, which is supported by a Novo Nordisk Foundation Challenge programme grant (Grant number NNF14SA0006). D.L.B. is a Wellcome senior clinical scientist [202747].",
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Pascal, MMV, Themistocleous, AC, Baron, R, Binder, A, Bouhassira, D, Crombez, G, Finnerup, NB, Gierthmühlen, J, Granovsky, Y, Groop, L, Hebert, HL, Jensen, TS, Johnsen, K, McCarthy, MI, Meng, W, Palmer, CNA, Rice, ASC, Serra, J, Solà, R, Yarnitsky, D, Smith, BH, Attal, N & Bennett, DLH 2018, 'DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain', Wellcome Open Research, vol. 3, 63, pp. 1-16. https://doi.org/10.12688/wellcomeopenres.14576.1

DOLORisk : study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain. / Pascal, Mathilde M. V. (Lead / Corresponding author); Themistocleous, Andreas C.; Baron, Ralf; Binder, Andreas; Bouhassira, Didier; Crombez, Geert ; Finnerup, Nanna B.; Gierthmühlen, Janne; Granovsky, Yelena; Groop, Leif ; Hebert, Harry L.; Jensen, Troels S.; Johnsen, Kristinn ; McCarthy, Mark I.; Meng, Weihua; Palmer, Colin N. A.; Rice, Andrew S. C.; Serra, Jordi; Solà, Romà ; Yarnitsky, David; Smith, Blair H.; Attal, Nadine; Bennett, David L. H. (Lead / Corresponding author).

In: Wellcome Open Research, Vol. 3, 63, 29.05.2018, p. 1-16.

Research output: Contribution to journalArticle

TY - JOUR

T1 - DOLORisk

T2 - study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain

AU - Pascal, Mathilde M. V.

AU - Themistocleous, Andreas C.

AU - Baron, Ralf

AU - Binder, Andreas

AU - Bouhassira, Didier

AU - Crombez, Geert

AU - Finnerup, Nanna B.

AU - Gierthmühlen, Janne

AU - Granovsky, Yelena

AU - Groop, Leif

AU - Hebert, Harry L.

AU - Jensen, Troels S.

AU - Johnsen, Kristinn

AU - McCarthy, Mark I.

AU - Meng, Weihua

AU - Palmer, Colin N. A.

AU - Rice, Andrew S. C.

AU - Serra, Jordi

AU - Solà, Romà

AU - Yarnitsky, David

AU - Smith, Blair H.

AU - Attal, Nadine

AU - Bennett, David L. H.

N1 - This work was supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 633491 (DOLORisk), and the International Diabetic Neuropathy Consortium (IDNC) research programme, which is supported by a Novo Nordisk Foundation Challenge programme grant (Grant number NNF14SA0006). D.L.B. is a Wellcome senior clinical scientist [202747].

PY - 2018/5/29

Y1 - 2018/5/29

N2 - Background: Neuropathic pain is an increasingly prevalent condition and has a major impact on health and quality of life. However, the risk factors for the development and maintenance of neuropathic pain are poorly understood. Clinical, genetic and psychosocial factors all contribute to chronic pain, but their interactions have not been studied in large cohorts. The DOLORisk study aims to study these factors.Protocol: Multicentre cross-sectional and longitudinal cohorts covering the main causes leading to neuropathic pain (e.g. diabetes, surgery, chemotherapy, traumatic injury), as well as rare conditions, follow a common protocol for phenotyping of the participants. This core protocol correlates answers given by the participants on a set of questionnaires with the results of their genetic analyses. A smaller number of participants undergo deeper phenotyping procedures, including neurological examination, nerve conduction studies, threshold tracking, quantitative sensory testing, conditioned pain modulation and electroencephalography.Ethics and dissemination: All studies have been approved by their regional ethics committees as required by national law. Results are disseminated through the DOLORisk website, scientific meetings, open-access publications, and in partnership with patient organisations.Strengths and limitations:- Large cohorts covering many possible triggers for neuropathic pain- Multi-disciplinary approach to study the interaction of clinical, psychosocial and genetic risk factors- High comparability of the data across centres thanks to harmonised protocols- One limitation is that the length of the questionnaires might reduce the response rate and quality of responses of participants

AB - Background: Neuropathic pain is an increasingly prevalent condition and has a major impact on health and quality of life. However, the risk factors for the development and maintenance of neuropathic pain are poorly understood. Clinical, genetic and psychosocial factors all contribute to chronic pain, but their interactions have not been studied in large cohorts. The DOLORisk study aims to study these factors.Protocol: Multicentre cross-sectional and longitudinal cohorts covering the main causes leading to neuropathic pain (e.g. diabetes, surgery, chemotherapy, traumatic injury), as well as rare conditions, follow a common protocol for phenotyping of the participants. This core protocol correlates answers given by the participants on a set of questionnaires with the results of their genetic analyses. A smaller number of participants undergo deeper phenotyping procedures, including neurological examination, nerve conduction studies, threshold tracking, quantitative sensory testing, conditioned pain modulation and electroencephalography.Ethics and dissemination: All studies have been approved by their regional ethics committees as required by national law. Results are disseminated through the DOLORisk website, scientific meetings, open-access publications, and in partnership with patient organisations.Strengths and limitations:- Large cohorts covering many possible triggers for neuropathic pain- Multi-disciplinary approach to study the interaction of clinical, psychosocial and genetic risk factors- High comparability of the data across centres thanks to harmonised protocols- One limitation is that the length of the questionnaires might reduce the response rate and quality of responses of participants

KW - pain

KW - neuropathy

KW - neuropathic pain

KW - diabetes

KW - nerve injury

KW - risk factors

KW - protocol

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U2 - 10.12688/wellcomeopenres.14576.1

DO - 10.12688/wellcomeopenres.14576.1

M3 - Article

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EP - 16

JO - Wellcome Open Research

JF - Wellcome Open Research

SN - 2398-502X

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