Protocol: Multicentre cross-sectional and longitudinal cohorts covering the main causes leading to neuropathic pain (e.g. diabetes, surgery, chemotherapy, traumatic injury), as well as rare conditions, follow a common protocol for phenotyping of the participants. This core protocol correlates answers given by the participants on a set of questionnaires with the results of their genetic analyses. A smaller number of participants undergo deeper phenotyping procedures, including neurological examination, nerve conduction studies, threshold tracking, quantitative sensory testing, conditioned pain modulation and electroencephalography.
Ethics and dissemination: All studies have been approved by their regional ethics committees as required by national law. Results are disseminated through the DOLORisk website, scientific meetings, open-access publications, and in partnership with patient organisations.
Strengths and limitations:
- Large cohorts covering many possible triggers for neuropathic pain
- Multi-disciplinary approach to study the interaction of clinical, psychosocial and genetic risk factors
- High comparability of the data across centres thanks to harmonised protocols
- One limitation is that the length of the questionnaires might reduce the response rate and quality of responses of participants
- neuropathic pain
- nerve injury
- risk factors