The eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation.
Sengupta, S., van Deursen, F., de Piccoli, G., & Labib, K. (2013). Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome. Current Biology, 23(7), 543-552. https://doi.org/10.1016/j.cub.2013.02.011