Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome

Sugopa Sengupta, Frederick van Deursen, Giacomo de Piccoli, Karim Labib (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    77 Citations (Scopus)

    Abstract

    The eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation.
    Original languageEnglish
    Pages (from-to)543-552
    Number of pages10
    JournalCurrent Biology
    Volume23
    Issue number7
    DOIs
    Publication statusPublished - 8 Apr 2013

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