Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome

Sugopa Sengupta; Frederick van Deursen; Giacomo de Piccoli; Karim Labib

doi:10.1016/j.cub.2013.02.011

Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome

Sugopa Sengupta, Frederick van Deursen, Giacomo de Piccoli, Karim Labib (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

The eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation.

Original language	English
Pages (from-to)	543-552
Number of pages	10
Journal	Current Biology
Volume	23
Issue number	7
DOIs	https://doi.org/10.1016/j.cub.2013.02.011
Publication status	Published - 8 Apr 2013

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title = "Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome",

abstract = "The eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation.",

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AB - The eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation.

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JO - Current Biology

JF - Current Biology

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Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome

Abstract

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