Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome

Sugopa Sengupta; Frederick van Deursen; Giacomo de Piccoli; Karim Labib

doi:10.1016/j.cub.2013.02.011

Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome

Sugopa Sengupta
, Frederick van Deursen
, Giacomo de Piccoli
, Karim Labib (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

117 Citations (Scopus)

Abstract

The eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation.

Original language	English
Pages (from-to)	543-552
Number of pages	10
Journal	Current Biology
Volume	23
Issue number	7
DOIs	https://doi.org/10.1016/j.cub.2013.02.011
Publication status	Published - 8 Apr 2013

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title = "Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome",

abstract = "The eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation.",

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AU - Sengupta, Sugopa

AU - van Deursen, Frederick

AU - de Piccoli, Giacomo

AU - Labib, Karim

PY - 2013/4/8

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N2 - The eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation.

AB - The eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation.

UR - https://www.scopus.com/pages/publications/84876108565

U2 - 10.1016/j.cub.2013.02.011

DO - 10.1016/j.cub.2013.02.011

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SN - 1879-0445

VL - 23

SP - 543

EP - 552

JO - Current Biology

JF - Current Biology

IS - 7

ER -

Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome

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