Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Jane M. Carlton; Robert P. Hirt; Joana C. Silva; Arthur L. Delcher; Michael Schatz; Qi Zhao; Jennifer R. Wortman; Shelby L. Bidwell; U. Cecilia M. Alsmark; Sebastien Besteiro; Thomas Sicheritz-Ponten; Christophe J. Noel; Joel B. Dacks; Peter G. Foster; Cedric Simillion; Yves Van de Peer; Diego Miranda-Saavedra; Geoffrey J. Barton; Gareth D. Westrop; Sylke Muller; Daniele Dessi; Pier Luigi Fiori; Qinghu Ren; Ian Paulsen; Hanbang Zhang; Felix D. Bastida-Corcuera; Augusto Simoes-Barbosa; Mark T. Brown; Richard D. Hayes; Mandira Mukherjee; Cheryl Y. Okumura; Rachel Schneider; Alias J. Smith; Stepanka Vanacova; Maria Villalvazo; Brian J. Haas; Mihaela Pertea; Tamara V. Feldblyum; Terry R. Utterback; Chung-Li Shu; Kazutoyo Osoegawa; Pieter J. de Jong; Ivan Hrdy; Lenka Horvathova; Zuzana Zubacova; Pavel Dolezal; Shehre-Banoo Malik; John M. Logsdon; Katrin Henze; Arti Gupta; Ching C. Wang; Rebecca L. Dunne; Jacqueline A. Upcroft; Peter Upcroft; Owen White; Steven L. Salzberg; Petrus Tang; Cheng-Hsun Chiu; Ying-Shiung Lee; T. Martin Embley; Graham H. Coombs; Jeremy C. Mottram; Jan Tachezy; Claire M. Fraser-Liggett; Patricia J. Johnson

doi:10.1126/science.1132894

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Jane M. Carlton, Robert P. Hirt, Joana C. Silva, Arthur L. Delcher, Michael Schatz, Qi Zhao, Jennifer R. Wortman, Shelby L. Bidwell, U. Cecilia M. Alsmark, Sebastien Besteiro, Thomas Sicheritz-Ponten, Christophe J. Noel, Joel B. Dacks, Peter G. Foster, Cedric Simillion, Yves Van de Peer, Diego Miranda-Saavedra, Geoffrey J. Barton, Gareth D. Westrop, Sylke MullerDaniele Dessi, Pier Luigi Fiori, Qinghu Ren, Ian Paulsen, Hanbang Zhang, Felix D. Bastida-Corcuera, Augusto Simoes-Barbosa, Mark T. Brown, Richard D. Hayes, Mandira Mukherjee, Cheryl Y. Okumura, Rachel Schneider, Alias J. Smith, Stepanka Vanacova, Maria Villalvazo, Brian J. Haas, Mihaela Pertea, Tamara V. Feldblyum, Terry R. Utterback, Chung-Li Shu, Kazutoyo Osoegawa, Pieter J. de Jong, Ivan Hrdy, Lenka Horvathova, Zuzana Zubacova, Pavel Dolezal, Shehre-Banoo Malik, John M. Logsdon, Katrin Henze, Arti Gupta, Ching C. Wang, Rebecca L. Dunne, Jacqueline A. Upcroft, Peter Upcroft, Owen White, Steven L. Salzberg, Petrus Tang, Cheng-Hsun Chiu, Ying-Shiung Lee, T. Martin Embley, Graham H. Coombs, Jeremy C. Mottram, Jan Tachezy, Claire M. Fraser-Liggett, Patricia J. Johnson

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Abstract

We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ~160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

Original language	English
Pages (from-to)	207-212
Number of pages	6
Journal	Science
Volume	315
Issue number	5809
DOIs	https://doi.org/10.1126/science.1132894
Publication status	Published - 2007

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Carlton, J. M., Hirt, R. P., Silva, J. C., Delcher, A. L., Schatz, M., Zhao, Q., Wortman, J. R., Bidwell, S. L., Alsmark, U. C. M., Besteiro, S., Sicheritz-Ponten, T., Noel, C. J., Dacks, J. B., Foster, P. G., Simillion, C., Van de Peer, Y., Miranda-Saavedra, D., Barton, G. J., Westrop, G. D., ... Johnson, P. J. (2007). Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science, 315(5809), 207-212. https://doi.org/10.1126/science.1132894

@article{f03f827a279c4daab8768aa98fc92ff9,

title = "Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis",

abstract = "We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ~160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.",

author = "Carlton, {Jane M.} and Hirt, {Robert P.} and Silva, {Joana C.} and Delcher, {Arthur L.} and Michael Schatz and Qi Zhao and Wortman, {Jennifer R.} and Bidwell, {Shelby L.} and Alsmark, {U. Cecilia M.} and Sebastien Besteiro and Thomas Sicheritz-Ponten and Noel, {Christophe J.} and Dacks, {Joel B.} and Foster, {Peter G.} and Cedric Simillion and {Van de Peer}, Yves and Diego Miranda-Saavedra and Barton, {Geoffrey J.} and Westrop, {Gareth D.} and Sylke Muller and Daniele Dessi and Fiori, {Pier Luigi} and Qinghu Ren and Ian Paulsen and Hanbang Zhang and Bastida-Corcuera, {Felix D.} and Augusto Simoes-Barbosa and Brown, {Mark T.} and Hayes, {Richard D.} and Mandira Mukherjee and Okumura, {Cheryl Y.} and Rachel Schneider and Smith, {Alias J.} and Stepanka Vanacova and Maria Villalvazo and Haas, {Brian J.} and Mihaela Pertea and Feldblyum, {Tamara V.} and Utterback, {Terry R.} and Chung-Li Shu and Kazutoyo Osoegawa and Jong, {Pieter J. de} and Ivan Hrdy and Lenka Horvathova and Zuzana Zubacova and Pavel Dolezal and Shehre-Banoo Malik and Logsdon, {John M.} and Katrin Henze and Arti Gupta and Wang, {Ching C.} and Dunne, {Rebecca L.} and Upcroft, {Jacqueline A.} and Peter Upcroft and Owen White and Salzberg, {Steven L.} and Petrus Tang and Cheng-Hsun Chiu and Ying-Shiung Lee and Embley, {T. Martin} and Coombs, {Graham H.} and Mottram, {Jeremy C.} and Jan Tachezy and Fraser-Liggett, {Claire M.} and Johnson, {Patricia J.}",

note = "dc.publisher: American Association for the Advancement of Science (AAAS) ",

year = "2007",

doi = "10.1126/science.1132894",

language = "English",

volume = "315",

pages = "207--212",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5809",

}

Carlton, JM, Hirt, RP, Silva, JC, Delcher, AL, Schatz, M, Zhao, Q, Wortman, JR, Bidwell, SL, Alsmark, UCM, Besteiro, S, Sicheritz-Ponten, T, Noel, CJ, Dacks, JB, Foster, PG, Simillion, C, Van de Peer, Y, Miranda-Saavedra, D, Barton, GJ, Westrop, GD, Muller, S, Dessi, D, Fiori, PL, Ren, Q, Paulsen, I, Zhang, H, Bastida-Corcuera, FD, Simoes-Barbosa, A, Brown, MT, Hayes, RD, Mukherjee, M, Okumura, CY, Schneider, R, Smith, AJ, Vanacova, S, Villalvazo, M, Haas, BJ, Pertea, M, Feldblyum, TV, Utterback, TR, Shu, C-L, Osoegawa, K, Jong, PJD, Hrdy, I, Horvathova, L, Zubacova, Z, Dolezal, P, Malik, S-B, Logsdon, JM, Henze, K, Gupta, A, Wang, CC, Dunne, RL, Upcroft, JA, Upcroft, P, White, O, Salzberg, SL, Tang, P, Chiu, C-H, Lee, Y-S, Embley, TM, Coombs, GH, Mottram, JC, Tachezy, J, Fraser-Liggett, CM & Johnson, PJ 2007, 'Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis', Science, vol. 315, no. 5809, pp. 207-212. https://doi.org/10.1126/science.1132894

TY - JOUR

T1 - Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

AU - Carlton, Jane M.

AU - Hirt, Robert P.

AU - Silva, Joana C.

AU - Delcher, Arthur L.

AU - Schatz, Michael

AU - Zhao, Qi

AU - Wortman, Jennifer R.

AU - Bidwell, Shelby L.

AU - Alsmark, U. Cecilia M.

AU - Besteiro, Sebastien

AU - Sicheritz-Ponten, Thomas

AU - Noel, Christophe J.

AU - Dacks, Joel B.

AU - Foster, Peter G.

AU - Simillion, Cedric

AU - Van de Peer, Yves

AU - Miranda-Saavedra, Diego

AU - Barton, Geoffrey J.

AU - Westrop, Gareth D.

AU - Muller, Sylke

AU - Dessi, Daniele

AU - Fiori, Pier Luigi

AU - Ren, Qinghu

AU - Paulsen, Ian

AU - Zhang, Hanbang

AU - Bastida-Corcuera, Felix D.

AU - Simoes-Barbosa, Augusto

AU - Brown, Mark T.

AU - Hayes, Richard D.

AU - Mukherjee, Mandira

AU - Okumura, Cheryl Y.

AU - Schneider, Rachel

AU - Smith, Alias J.

AU - Vanacova, Stepanka

AU - Villalvazo, Maria

AU - Haas, Brian J.

AU - Pertea, Mihaela

AU - Feldblyum, Tamara V.

AU - Utterback, Terry R.

AU - Shu, Chung-Li

AU - Osoegawa, Kazutoyo

AU - Jong, Pieter J. de

AU - Hrdy, Ivan

AU - Horvathova, Lenka

AU - Zubacova, Zuzana

AU - Dolezal, Pavel

AU - Malik, Shehre-Banoo

AU - Logsdon, John M.

AU - Henze, Katrin

AU - Gupta, Arti

AU - Wang, Ching C.

AU - Dunne, Rebecca L.

AU - Upcroft, Jacqueline A.

AU - Upcroft, Peter

AU - White, Owen

AU - Salzberg, Steven L.

AU - Tang, Petrus

AU - Chiu, Cheng-Hsun

AU - Lee, Ying-Shiung

AU - Embley, T. Martin

AU - Coombs, Graham H.

AU - Mottram, Jeremy C.

AU - Tachezy, Jan

AU - Fraser-Liggett, Claire M.

AU - Johnson, Patricia J.

N1 - dc.publisher: American Association for the Advancement of Science (AAAS)

PY - 2007

Y1 - 2007

N2 - We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ~160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

AB - We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ~160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

U2 - 10.1126/science.1132894

DO - 10.1126/science.1132894

M3 - Article

C2 - 17218520

SN - 0036-8075

VL - 315

SP - 207

EP - 212

JO - Science

JF - Science

IS - 5809

ER -

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Abstract

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