Drosophila as an in vivo model for human neurodegenerative disease

Leeanne McGurk, Amit Berson, Nancy M. Bonini (Lead / Corresponding author)

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

With the increase in the ageing population, neurodegenerative disease is devastating to families and poses a huge burden on society. The brain and spinal cord are extraordinarily complex: they consist of a highly organized network of neuronal and support cells that communicate in a highly specializedmanner.One approach to tackling problems of such complexity is to address the scientific questions in simpler, yet analogous, systems. The fruit fly, Drosophila melanogaster, has been proven tremendously valuable as a model organism, enabling many major discoveries in neuroscientific disease research. The plethora of genetic tools available in Drosophila allows for exquisite targeted manipulation of the genome. Due to its relatively short lifespan, complex questions of brain function can be addressed more rapidly than in other model organisms, such as the mouse. Here we discuss features of the fly as a model for human neurodegenerative disease. There are many distinct fly models for a range of neurodegenerative diseases; we focus on select studies from models of polyglutamine disease and amyotrophic lateral sclerosis that illustrate the type and range of insights that can be gleaned. In discussion of these models, we underscore strengths of the fly in providing understanding into mechanisms and pathways, as a foundation for translational and therapeutic research.

Original languageEnglish
Pages (from-to)377-402
Number of pages26
JournalGenetics
Volume201
Issue number2
Early online date7 Oct 2015
DOIs
Publication statusPublished - Oct 2015

Keywords

  • ALS
  • Drosophila
  • FlyBook
  • FTD
  • Genetic pathways
  • Polyglutamine disease
  • Protein toxicity

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