Drug discovery for neglected diseases: molecular target-based and phenotypic approaches

    Research output: Contribution to journalArticle

    114 Citations (Scopus)

    Abstract

    Drug discovery for neglected tropical diseases is carried out using both target-based and phenotypic approaches. In this paper, target-based approaches are discussed, with a particular focus on human African trypanosomiasis. Target-based drug discovery can be successful, but careful selection of targets is required. There are still very few fully validated drug targets in neglected diseases, and there is a high attrition rate in target-based drug discovery for these diseases. Phenotypic screening is a powerful method in both neglected and non-neglected diseases and has been very successfully used. Identification of molecular targets from phenotypic approaches can be a way to identify potential new drug targets.
    Original languageEnglish
    Pages (from-to)7719-7726
    Number of pages8
    JournalJournal of Medicinal Chemistry
    Volume56
    Issue number20
    DOIs
    Publication statusPublished - 2013

    Fingerprint Dive into the research topics of 'Drug discovery for neglected diseases: molecular target-based and phenotypic approaches'. Together they form a unique fingerprint.

  • Cite this