Abstract
Drug discovery for neglected tropical diseases is carried out using both target-based and phenotypic approaches. In this paper, target-based approaches are discussed, with a particular focus on human African trypanosomiasis. Target-based drug discovery can be successful, but careful selection of targets is required. There are still very few fully validated drug targets in neglected diseases, and there is a high attrition rate in target-based drug discovery for these diseases. Phenotypic screening is a powerful method in both neglected and non-neglected diseases and has been very successfully used. Identification of molecular targets from phenotypic approaches can be a way to identify potential new drug targets.
Original language | English |
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Pages (from-to) | 7719-7726 |
Number of pages | 8 |
Journal | Journal of Medicinal Chemistry |
Volume | 56 |
Issue number | 20 |
DOIs | |
Publication status | Published - 2013 |