E-cadherin repression contributes to c-Myc-induced epithelial cell transformation

V H Cowling, M D Cole

    Research output: Contribution to journalArticlepeer-review

    45 Citations (Scopus)

    Abstract

    c-Myc oncoprotein is overexpressed in a significant proportion of human epithelial cancers, and experimental overexpression of c-Myc in epithelial cells promotes tumour formation. However, it is not known how c-Myc promotes epithelial cell tumour formation. We report that c-Myc expression in human mammary epithelial cells induces a dramatic change in cell morphology, with some characteristics of an 'epithelial to mesenchymal transition'. E-cadherin expression is repressed by a post-transcriptional mechanism in cells expressing c-Myc. Furthermore, E-cadherin repression is necessary for c-Myc-induced cell transformation.
    Original languageEnglish
    Pages (from-to)3582-6
    Number of pages5
    JournalOncogene
    Volume26
    Issue number24
    DOIs
    Publication statusPublished - 2007

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