Early and late vulval cancer recurrences: Are they different?

Kalpana Ragupathy (Lead / Corresponding author), Lisa Grandidge, Katie Strelley, Huan Wang, John Tidy

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)


    Vulval cancers are rare, but after primary treatment, known to recur with a high frequency (30%). Clinico-pathological predictors of recurrence have been established to a great extent. However, there is paucity of literature on predictors of early versus late recurrence. We sought to identify such predictors through a retrospective study of vulval cancer recurrences in a single cancer centre over 11 years. Age of women, depth of invasion/site of primary tumour and presence of background VIN/lichen sclerosus do not appear to affect timing of recurrence. However, vulval cancers that recur after 2 years of primary tumour recognition are more likely to be well-differentiated tumours, have undergone radical surgery and have had a closest disease-free margin >1 cm. Late recurrences are entirely local rather than distant metastases and this translates into a better survival as shown in our study (40 months median survival in the early group versus 112 in the late recurrence group).

    Original languageEnglish
    Pages (from-to)518-521
    Number of pages4
    JournalJournal of Obstetrics & Gynaecology
    Issue number4
    Publication statusPublished - 2016


    • Adult
    • Aged
    • Aged, 80 and over
    • Female
    • Humans
    • Lichen sclerosus et atrophicus
    • Middle aged
    • Neoplasm invasiveness
    • Neoplasm recurrence, Local
    • Retrospective studies
    • Risk factors
    • Time factors
    • Vulvar neoplasms
    • Journal article


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