Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections: Retrospective Analysis of 2 Randomized Controlled Trials

Dilip Nathwani, Ralph Corey, Anita F. Das, Taylor Sandison, Carisa De Anda, Philippe Prokocimer (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    In the treatment of acute bacterial skin and skin structure infections, pooled data from 2 clinical trials (N = 1333 patients) showed that programmatic and investigator-assessed early treatment success both had a high positive predictive value (94.3%-100.0%) for late clinical cure, including among hospitalized patients. The negative predictive value of programmatic early success was <20%. These exploratory findings require prospective real-world evaluation.

    CLINICAL TRIALS REGISTRATION:  NCT01170221; NCT01421511.

    Original languageEnglish
    Pages (from-to)214-217
    Number of pages4
    JournalClinical Infectious Diseases
    Volume64
    Issue number2
    Early online date21 Dec 2016
    DOIs
    Publication statusPublished - 15 Jan 2017

    Keywords

    • Tedizolid
    • Oxazolidinones
    • ABSSSI
    • Antibacterial therapy
    • Treatment outcomes

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