Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections: Retrospective Analysis of 2 Randomized Controlled Trials

Dilip Nathwani; Ralph Corey; Anita F. Das; Taylor Sandison; Carisa De Anda; Philippe Prokocimer

doi:10.1093/cid/ciw750

Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections: Retrospective Analysis of 2 Randomized Controlled Trials

Dilip Nathwani, Ralph Corey, Anita F. Das, Taylor Sandison, Carisa De Anda, Philippe Prokocimer (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

In the treatment of acute bacterial skin and skin structure infections, pooled data from 2 clinical trials (N = 1333 patients) showed that programmatic and investigator-assessed early treatment success both had a high positive predictive value (94.3%-100.0%) for late clinical cure, including among hospitalized patients. The negative predictive value of programmatic early success was <20%. These exploratory findings require prospective real-world evaluation.

CLINICAL TRIALS REGISTRATION: NCT01170221; NCT01421511.

Original language	English
Pages (from-to)	214-217
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	64
Issue number	2
Early online date	21 Dec 2016
DOIs	https://doi.org/10.1093/cid/ciw750
Publication status	Published - 15 Jan 2017

Keywords

Tedizolid
Oxazolidinones
ABSSSI
Antibacterial therapy
Treatment outcomes

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10.1093/cid/ciw750

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title = "Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections: Retrospective Analysis of 2 Randomized Controlled Trials",

abstract = "In the treatment of acute bacterial skin and skin structure infections, pooled data from 2 clinical trials (N = 1333 patients) showed that programmatic and investigator-assessed early treatment success both had a high positive predictive value (94.3%-100.0%) for late clinical cure, including among hospitalized patients. The negative predictive value of programmatic early success was <20%. These exploratory findings require prospective real-world evaluation.CLINICAL TRIALS REGISTRATION: NCT01170221; NCT01421511.",

keywords = "Tedizolid, Oxazolidinones, ABSSSI, Antibacterial therapy, Treatment outcomes",

author = "Dilip Nathwani and Ralph Corey and Das, {Anita F.} and Taylor Sandison and {De Anda}, Carisa and Philippe Prokocimer",

note = "This work was supported by Merck & Co, Inc, USA.",

year = "2017",

month = jan,

day = "15",

doi = "10.1093/cid/ciw750",

language = "English",

volume = "64",

pages = "214--217",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

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Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections: Retrospective Analysis of 2 Randomized Controlled Trials. / Nathwani, Dilip; Corey, Ralph; Das, Anita F. et al.
In: Clinical Infectious Diseases, Vol. 64, No. 2, 15.01.2017, p. 214-217.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections

T2 - Retrospective Analysis of 2 Randomized Controlled Trials

AU - Nathwani, Dilip

AU - Corey, Ralph

AU - Das, Anita F.

AU - Sandison, Taylor

AU - De Anda, Carisa

AU - Prokocimer, Philippe

N1 - This work was supported by Merck & Co, Inc, USA.

PY - 2017/1/15

Y1 - 2017/1/15

N2 - In the treatment of acute bacterial skin and skin structure infections, pooled data from 2 clinical trials (N = 1333 patients) showed that programmatic and investigator-assessed early treatment success both had a high positive predictive value (94.3%-100.0%) for late clinical cure, including among hospitalized patients. The negative predictive value of programmatic early success was <20%. These exploratory findings require prospective real-world evaluation.CLINICAL TRIALS REGISTRATION: NCT01170221; NCT01421511.

AB - In the treatment of acute bacterial skin and skin structure infections, pooled data from 2 clinical trials (N = 1333 patients) showed that programmatic and investigator-assessed early treatment success both had a high positive predictive value (94.3%-100.0%) for late clinical cure, including among hospitalized patients. The negative predictive value of programmatic early success was <20%. These exploratory findings require prospective real-world evaluation.CLINICAL TRIALS REGISTRATION: NCT01170221; NCT01421511.

KW - Tedizolid

KW - Oxazolidinones

KW - ABSSSI

KW - Antibacterial therapy

KW - Treatment outcomes

U2 - 10.1093/cid/ciw750

DO - 10.1093/cid/ciw750

M3 - Article

C2 - 28003218

SN - 1058-4838

VL - 64

SP - 214

EP - 217

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 2

ER -

Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections: Retrospective Analysis of 2 Randomized Controlled Trials

Abstract

Keywords

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