TY - JOUR
T1 - Early life antibiotic use and the risk of asthma and asthma exacerbations in children
AU - Ahmadizar, Fariba
AU - Vijverberg, Susanne J. H.
AU - Arets, Hubertus G. M.
AU - de Boer, Anthonius
AU - Turner, Steve
AU - Devereux, Graham
AU - Arabkhazaeli, Ali
AU - Soares, Patricia
AU - Mukhopadhyay, Somnath
AU - Garssen, Johan
AU - Palmer, Colin N. A.
AU - de Jongste, Johan C.
AU - Jaddoe, Vincent W. V.
AU - Duijts, Liesbeth
AU - van Meel, Evelien R.
AU - Kraneveld, Aletta D.
AU - Maitland-van der Zee, Anke H.
N1 - No funding source had any role in the design and conduct of the study, the collection, management, analysis and interpretation of the data or the preparation, review or approval of the manuscript.
PY - 2017/8
Y1 - 2017/8
N2 - Background: The use of antibiotic therapy early in life might influence the risk of developing asthma. Studies assessing the influence of early life antibiotic use on the risk of asthma exacerbations are limited, and the results are inconsistent. Therefore, the aim of this study was to assess the association between use of antibiotic during the first three years of life and the risk of developing childhood asthma and the occurrence of asthma exacerbations.Methods: Data from four large childhood cohorts were used; two population-based cohorts to study the risk of developing asthma: Generation R (n=7,393, the Netherlands) and SEATON (n=891, Scotland, UK), and two asthma cohorts to assess the risk of asthma exacerbations: PACMAN (n=668, the Netherlands) and BREATHE (n=806, Scotland, UK). Odds ratios (ORs) were derived from logistic regression analysis within each database followed by pooling the results using a fixed- or random-effect model.Results: Antibiotic use in early life was associated with an increased risk of asthma in a meta-analysis of the Generation R and SEATON data (OR: 2.18, 95% CI: 1.04-4.60; I(2) : 76.3%). There was no association between antibiotic use in early life and risk of asthma exacerbations later in life in a meta-analysis of the PACMAN and BREATHE data (OR: 0.93, 95% CI: 0.65-1.32; I(2) : 0.0%).Conclusion: Children treated with antibiotic in the first three years of life are more likely to develop asthma, but there is no evidence that the exposure to antibiotic is associated with increased risk of asthma exacerbations. This article is protected by copyright. All rights reserved.
AB - Background: The use of antibiotic therapy early in life might influence the risk of developing asthma. Studies assessing the influence of early life antibiotic use on the risk of asthma exacerbations are limited, and the results are inconsistent. Therefore, the aim of this study was to assess the association between use of antibiotic during the first three years of life and the risk of developing childhood asthma and the occurrence of asthma exacerbations.Methods: Data from four large childhood cohorts were used; two population-based cohorts to study the risk of developing asthma: Generation R (n=7,393, the Netherlands) and SEATON (n=891, Scotland, UK), and two asthma cohorts to assess the risk of asthma exacerbations: PACMAN (n=668, the Netherlands) and BREATHE (n=806, Scotland, UK). Odds ratios (ORs) were derived from logistic regression analysis within each database followed by pooling the results using a fixed- or random-effect model.Results: Antibiotic use in early life was associated with an increased risk of asthma in a meta-analysis of the Generation R and SEATON data (OR: 2.18, 95% CI: 1.04-4.60; I(2) : 76.3%). There was no association between antibiotic use in early life and risk of asthma exacerbations later in life in a meta-analysis of the PACMAN and BREATHE data (OR: 0.93, 95% CI: 0.65-1.32; I(2) : 0.0%).Conclusion: Children treated with antibiotic in the first three years of life are more likely to develop asthma, but there is no evidence that the exposure to antibiotic is associated with increased risk of asthma exacerbations. This article is protected by copyright. All rights reserved.
KW - Antibiotic
KW - Asthma
KW - Asthma exacerbations
KW - Early life
KW - Pediatrics
U2 - 10.1111/pai.12725
DO - 10.1111/pai.12725
M3 - Article
C2 - 28423467
SN - 0905-6157
VL - 28
SP - 430
EP - 437
JO - Pediatric Allergy and Immunology
JF - Pediatric Allergy and Immunology
IS - 5
ER -