Early Life Nutritional Programming of Obesity: Mother-Child Cohort Studies

Michael E. Symonds, Michelle A. Mendez, Helle Margrete Meltzer, Berthold Koletzko, Keith Godfrey, Stewart Forsyth, Eline M. van der Beek

    Research output: Contribution to journalArticlepeer-review

    74 Citations (Scopus)

    Abstract

    Background: The obesity epidemic has resulted in more overweight/obese women before and during pregnancy. Their offspring tend to have higher birth weights and more body fat, and carry an increased risk of obesity later in life. These effects may partly be related to the heightened risk of gestational diabetes, occurring in at least 16% of all pregnancies irrespective of current body weight. Methods: An ILSI Europe workshop reviewed the key contributors leading to adverse outcomes in pregnancy and childhood, including gestational weight gain and nutrition. New research opportunities from prospective mother-child cohort studies were explored. Results: Simple measures of gestational weight gain provide insufficient detail of the underlying physiological and metabolic adaptations occurring in pregnancy, and should be complemented by measures of body composition, metabolic and endocrine responses. Recordings of maternal dietary intake and nutrient status are often limited and potential correlations with gestational weight gain have been poorly studied. Many pregnancies in overweight/obese women are uncomplicated and result in offspring of normal weight, leaving the main determinants of later adverse outcomes to be clarified. Conclusions: The workshop provided insights of primary measurements for the characterization of sustainable nutritional intervention strategies in the mother, infant and child for preventing obesity in later life. copyright (C) 2013 S. Karger AG, Basel

    Original languageEnglish
    Pages (from-to)137-145
    Number of pages9
    JournalAnnals of Nutrition and Metabolism
    Volume62
    Issue number2
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Obesity
    • MATERNAL OBESITY
    • BODY-MASS INDEX
    • DIABETES-MELLITUS
    • GESTATIONAL WEIGHT-GAIN
    • Insulin resistance
    • Pregnancy
    • METABOLIC SYNDROME
    • RANDOMIZED CLINICAL-TRIAL
    • PREGNANCY OUTCOMES
    • DEVELOPMENTAL ORIGINS
    • BIRTH COHORTS
    • BROWN ADIPOSE-TISSUE

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