Eating your mitochondria – when too much of a good thing turns bad

Léa P. Wilhelm, Ian G. Ganley (Lead / Corresponding author)

Research output: Contribution to journalComment/debatepeer-review

1 Citation (Scopus)
28 Downloads (Pure)

Abstract

How mitophagy is turned on to remove damaged or excess mitochondria from cells has been well-studied, but less is known about how the pathway is turned off to avoid ‘over-eating’ of mitochondria under basal conditions. Three new studies now reveal the disease-associated FBXL4 protein as an important negative regulator of constitutive mitophagy, controlling the stability of mitophagy receptors BNIP3 and NIX.
Original languageEnglish
Article numbere114542
Number of pages3
JournalEMBO Journal
Volume42
Issue number13
Early online date5 Jun 2023
DOIs
Publication statusPublished - 3 Jul 2023

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