Eating your mitochondria – when too much of a good thing turns bad

Léa P. Wilhelm; Ian G. Ganley

doi:10.15252/embj.2023114542

Eating your mitochondria – when too much of a good thing turns bad

Léa P. Wilhelm, Ian G. Ganley (Lead / Corresponding author)

MRC PPU

Research output: Contribution to journal › Comment/debate › peer-review

3 Citations (Scopus)

106 Downloads (Pure)

Abstract

How mitophagy is turned on to remove damaged or excess mitochondria from cells has been well-studied, but less is known about how the pathway is turned off to avoid ‘over-eating’ of mitochondria under basal conditions. Three new studies now reveal the disease-associated FBXL4 protein as an important negative regulator of constitutive mitophagy, controlling the stability of mitophagy receptors BNIP3 and NIX.

Original language	English
Article number	e114542
Number of pages	3
Journal	EMBO Journal
Volume	42
Issue number	13
Early online date	5 Jun 2023
DOIs	https://doi.org/10.15252/embj.2023114542
Publication status	Published - 3 Jul 2023

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title = "Eating your mitochondria – when too much of a good thing turns bad",

abstract = "How mitophagy is turned on to remove damaged or excess mitochondria from cells has been well-studied, but less is known about how the pathway is turned off to avoid {\textquoteleft}over-eating{\textquoteright} of mitochondria under basal conditions. Three new studies now reveal the disease-associated FBXL4 protein as an important negative regulator of constitutive mitophagy, controlling the stability of mitophagy receptors BNIP3 and NIX.",

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AU - Wilhelm, Léa P.

AU - Ganley, Ian G.

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N2 - How mitophagy is turned on to remove damaged or excess mitochondria from cells has been well-studied, but less is known about how the pathway is turned off to avoid ‘over-eating’ of mitochondria under basal conditions. Three new studies now reveal the disease-associated FBXL4 protein as an important negative regulator of constitutive mitophagy, controlling the stability of mitophagy receptors BNIP3 and NIX.

AB - How mitophagy is turned on to remove damaged or excess mitochondria from cells has been well-studied, but less is known about how the pathway is turned off to avoid ‘over-eating’ of mitochondria under basal conditions. Three new studies now reveal the disease-associated FBXL4 protein as an important negative regulator of constitutive mitophagy, controlling the stability of mitophagy receptors BNIP3 and NIX.

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U2 - 10.15252/embj.2023114542

DO - 10.15252/embj.2023114542

M3 - Comment/debate

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SN - 0261-4189

VL - 42

JO - EMBO Journal

JF - EMBO Journal

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Eating your mitochondria – when too much of a good thing turns bad

Abstract

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