ECAS A-B-C: alternate forms of the Edinburgh Cognitive and Behavioural ALS Screen

Christopher J. Crockford (Lead / Corresponding author), Michaela Kleynhans, Evelyn Wilton, Ratko Radakovic, Judith Newton, Elaine H. Niven, Ammar Al-Chalabi, Orla Hardiman, Thomas H. Bak, Sharon Abrahams

Research output: Contribution to journalArticle

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Abstract

Background: The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) is a short assessment by which neuropsychological symptoms can be detected and quantified in people with ALS. To avoid potential practice effects with repeated administration, here we present alternative versions of the ECAS suitable for measuring change over time. Objective: To develop two alternate versions of the ECAS: ECAS-B and ECAS-C. Method: One hundred and forty-nine healthy adult participants were recruited. Thirty participants completed a pilot study in developing the alternate versions. Two groups of 40 participants were administered the ECAS-B or ECAS-C and compared to published data of the original ECAS (ECAS-A) to determine equivalence. An additional 39 participants were administered the ECAS consecutively, either repeating the original version (ECAS-A-A-A) serially or the different versions (ECAS-A-B-C) to determine potential practice effects. Recordings of assessments were scored by a second researcher to determine inter-rater reliability. Results: No significant differences were found between versions (A, B, C) of the composite performance measures of ALS Specific, ALS Non-Specific, and ECAS Total scores. Repeated serial administration of ECAS-A (A-A-A) produced some practice effects for composite scores, whereas no such effects were found when alternate versions were administered serially (A-B-C). Exceptionally high intra-class correlations were found for all three versions of the ECAS suggesting a high degree of rater agreement. Conclusion: The newly developed alternate forms of the ECAS are both highly equitable to the original ECAS-A and enable avoidance of practice effects, thus supporting their use in measuring cognition and behaviour over time.
Original languageEnglish
Number of pages8
JournalAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Early online date5 Dec 2017
DOIs
Publication statusE-pub ahead of print - 5 Dec 2017

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Keywords

  • Cognition
  • Behaviour
  • Screen
  • ECAS
  • Alternate forms
  • Reliability

Cite this

Crockford, Christopher J. ; Kleynhans, Michaela ; Wilton, Evelyn ; Radakovic, Ratko ; Newton, Judith ; Niven, Elaine H. ; Al-Chalabi, Ammar ; Hardiman, Orla ; Bak, Thomas H. ; Abrahams, Sharon. / ECAS A-B-C : alternate forms of the Edinburgh Cognitive and Behavioural ALS Screen. In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2017.
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title = "ECAS A-B-C: alternate forms of the Edinburgh Cognitive and Behavioural ALS Screen",
abstract = "Background: The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) is a short assessment by which neuropsychological symptoms can be detected and quantified in people with ALS. To avoid potential practice effects with repeated administration, here we present alternative versions of the ECAS suitable for measuring change over time. Objective: To develop two alternate versions of the ECAS: ECAS-B and ECAS-C. Method: One hundred and forty-nine healthy adult participants were recruited. Thirty participants completed a pilot study in developing the alternate versions. Two groups of 40 participants were administered the ECAS-B or ECAS-C and compared to published data of the original ECAS (ECAS-A) to determine equivalence. An additional 39 participants were administered the ECAS consecutively, either repeating the original version (ECAS-A-A-A) serially or the different versions (ECAS-A-B-C) to determine potential practice effects. Recordings of assessments were scored by a second researcher to determine inter-rater reliability. Results: No significant differences were found between versions (A, B, C) of the composite performance measures of ALS Specific, ALS Non-Specific, and ECAS Total scores. Repeated serial administration of ECAS-A (A-A-A) produced some practice effects for composite scores, whereas no such effects were found when alternate versions were administered serially (A-B-C). Exceptionally high intra-class correlations were found for all three versions of the ECAS suggesting a high degree of rater agreement. Conclusion: The newly developed alternate forms of the ECAS are both highly equitable to the original ECAS-A and enable avoidance of practice effects, thus supporting their use in measuring cognition and behaviour over time.",
keywords = "Cognition, Behaviour, Screen, ECAS, Alternate forms, Reliability",
author = "Crockford, {Christopher J.} and Michaela Kleynhans and Evelyn Wilton and Ratko Radakovic and Judith Newton and Niven, {Elaine H.} and Ammar Al-Chalabi and Orla Hardiman and Bak, {Thomas H.} and Sharon Abrahams",
note = "This work was supported by a grant from the Amyotrophic Lateral Sclerosis Association [ALSA; ID: 179]. The project is supported through the following funding organizations under the aegis of JPND - http://www.jpnd.eu (United Kingdom, Medical Research Council [MR/L501529/1], Economic and Social Research Council [ES/L008238/1], and Irish Health Research Board [HRB-JPND/2013/1]). CC receives support from the Euan MacDonald Centre for Motor Neurone Disease Research. AAC receives salary support from the National Institute for Health Research Maudsley Biomedical Research Centre.",
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ECAS A-B-C : alternate forms of the Edinburgh Cognitive and Behavioural ALS Screen. / Crockford, Christopher J. (Lead / Corresponding author); Kleynhans, Michaela; Wilton, Evelyn; Radakovic, Ratko; Newton, Judith; Niven, Elaine H.; Al-Chalabi, Ammar; Hardiman, Orla; Bak, Thomas H.; Abrahams, Sharon.

In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 05.12.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - ECAS A-B-C

T2 - alternate forms of the Edinburgh Cognitive and Behavioural ALS Screen

AU - Crockford, Christopher J.

AU - Kleynhans, Michaela

AU - Wilton, Evelyn

AU - Radakovic, Ratko

AU - Newton, Judith

AU - Niven, Elaine H.

AU - Al-Chalabi, Ammar

AU - Hardiman, Orla

AU - Bak, Thomas H.

AU - Abrahams, Sharon

N1 - This work was supported by a grant from the Amyotrophic Lateral Sclerosis Association [ALSA; ID: 179]. The project is supported through the following funding organizations under the aegis of JPND - http://www.jpnd.eu (United Kingdom, Medical Research Council [MR/L501529/1], Economic and Social Research Council [ES/L008238/1], and Irish Health Research Board [HRB-JPND/2013/1]). CC receives support from the Euan MacDonald Centre for Motor Neurone Disease Research. AAC receives salary support from the National Institute for Health Research Maudsley Biomedical Research Centre.

PY - 2017/12/5

Y1 - 2017/12/5

N2 - Background: The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) is a short assessment by which neuropsychological symptoms can be detected and quantified in people with ALS. To avoid potential practice effects with repeated administration, here we present alternative versions of the ECAS suitable for measuring change over time. Objective: To develop two alternate versions of the ECAS: ECAS-B and ECAS-C. Method: One hundred and forty-nine healthy adult participants were recruited. Thirty participants completed a pilot study in developing the alternate versions. Two groups of 40 participants were administered the ECAS-B or ECAS-C and compared to published data of the original ECAS (ECAS-A) to determine equivalence. An additional 39 participants were administered the ECAS consecutively, either repeating the original version (ECAS-A-A-A) serially or the different versions (ECAS-A-B-C) to determine potential practice effects. Recordings of assessments were scored by a second researcher to determine inter-rater reliability. Results: No significant differences were found between versions (A, B, C) of the composite performance measures of ALS Specific, ALS Non-Specific, and ECAS Total scores. Repeated serial administration of ECAS-A (A-A-A) produced some practice effects for composite scores, whereas no such effects were found when alternate versions were administered serially (A-B-C). Exceptionally high intra-class correlations were found for all three versions of the ECAS suggesting a high degree of rater agreement. Conclusion: The newly developed alternate forms of the ECAS are both highly equitable to the original ECAS-A and enable avoidance of practice effects, thus supporting their use in measuring cognition and behaviour over time.

AB - Background: The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) is a short assessment by which neuropsychological symptoms can be detected and quantified in people with ALS. To avoid potential practice effects with repeated administration, here we present alternative versions of the ECAS suitable for measuring change over time. Objective: To develop two alternate versions of the ECAS: ECAS-B and ECAS-C. Method: One hundred and forty-nine healthy adult participants were recruited. Thirty participants completed a pilot study in developing the alternate versions. Two groups of 40 participants were administered the ECAS-B or ECAS-C and compared to published data of the original ECAS (ECAS-A) to determine equivalence. An additional 39 participants were administered the ECAS consecutively, either repeating the original version (ECAS-A-A-A) serially or the different versions (ECAS-A-B-C) to determine potential practice effects. Recordings of assessments were scored by a second researcher to determine inter-rater reliability. Results: No significant differences were found between versions (A, B, C) of the composite performance measures of ALS Specific, ALS Non-Specific, and ECAS Total scores. Repeated serial administration of ECAS-A (A-A-A) produced some practice effects for composite scores, whereas no such effects were found when alternate versions were administered serially (A-B-C). Exceptionally high intra-class correlations were found for all three versions of the ECAS suggesting a high degree of rater agreement. Conclusion: The newly developed alternate forms of the ECAS are both highly equitable to the original ECAS-A and enable avoidance of practice effects, thus supporting their use in measuring cognition and behaviour over time.

KW - Cognition

KW - Behaviour

KW - Screen

KW - ECAS

KW - Alternate forms

KW - Reliability

U2 - 10.1080/21678421.2017.1407793

DO - 10.1080/21678421.2017.1407793

M3 - Article

C2 - 29205065

JO - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

JF - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

SN - 2167-8421

ER -