Ectopic recruitment of neuroblasts in striatal myelin bundles and nucleus accumbens following AraC chemical lesion

TY - JOUR

T1 - Ectopic recruitment of neuroblasts in striatal myelin bundles and nucleus accumbens following AraC chemical lesion

AU - Thanou, Irini

AU - Koutsoudaki, Paraskevi N.

AU - Margariti, Maria

AU - Luzzati, Federico

AU - Havaki, Sophia

AU - Gorgoulis, Vassilis G.

AU - Thomaidou, Dimitra

N1 - Publisher Copyright: © 2025 The Authors

PY - 2025/9/9

Y1 - 2025/9/9

N2 - In the adult brain, neural stem cells (NSCs) constitutively generate new neurons in specific neurogenic domains. Recent research has unveiled reactive neurogenesis, whereby brain injury triggers NSC activation, enhancing their differentiation potential and guiding progeny to injured areas. Our study provides evidence of alternative migration pathways for newborn neurons in the mouse subcortical forebrain, revealed by administration of a chemotherapeutic agent. This allows a high number of newborn neurons to migrate long distances over an extended period. Notably, a subpopulation of neuroblasts diverts from the canonical SVZ-olfactory bulb (OB) rostral migratory stream toward the striatum (STR), with distinct localization along striatal myelin tracts and through nucleus accumbens (NAc) to the anterior commissure (AC). This neuroblast (NB) rerouting is accompanied by with oligodendrocyte lineage dysregulation and myelin deficits, suggesting a link between ectopic NB presence and observed myelin abnormalities.

AB - In the adult brain, neural stem cells (NSCs) constitutively generate new neurons in specific neurogenic domains. Recent research has unveiled reactive neurogenesis, whereby brain injury triggers NSC activation, enhancing their differentiation potential and guiding progeny to injured areas. Our study provides evidence of alternative migration pathways for newborn neurons in the mouse subcortical forebrain, revealed by administration of a chemotherapeutic agent. This allows a high number of newborn neurons to migrate long distances over an extended period. Notably, a subpopulation of neuroblasts diverts from the canonical SVZ-olfactory bulb (OB) rostral migratory stream toward the striatum (STR), with distinct localization along striatal myelin tracts and through nucleus accumbens (NAc) to the anterior commissure (AC). This neuroblast (NB) rerouting is accompanied by with oligodendrocyte lineage dysregulation and myelin deficits, suggesting a link between ectopic NB presence and observed myelin abnormalities.

KW - adult neurogenesis

KW - AraC

KW - ectopic migration

KW - lesion-induced neurogenesis

KW - myelin bundles

KW - neuroblasts

KW - striatum

KW - subventricular zone

UR - https://www.scopus.com/pages/publications/105015211890

U2 - 10.1016/j.stemcr.2025.102636

DO - 10.1016/j.stemcr.2025.102636

M3 - Article

C2 - 40930069

AN - SCOPUS:105015211890

VL - 20

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 9

M1 - 102636

ER -