Eczema genetics: current state of knowledge and future goals

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    Abstract

    Multiple genetic as well as environmental factors interact in the pathogenesis of eczema. Increased understanding of genetic predisposition in atopy and eczema has directed interest toward key pathogenic mechanisms including skin barrier dysfunction. This review provides a succinct update on the current state of knowledge regarding eczema genetics. We discuss the relevance of loss-of-function mutations in the filaggrin gene within the context of other candidate gene studies and suggest possible applications for future research. Knowledge of genetic factors in eczema may translate into a clearer understanding of pathogenic mechanisms and hence more focused therapeutic strategies, but this remains at present a distant possibility.

    Original languageEnglish
    Pages (from-to)543-552
    Number of pages10
    JournalJournal of Investigative Dermatology
    Volume129
    Issue number3
    DOIs
    Publication statusPublished - Mar 2009

    Keywords

    • Of-function mutations
    • Irritant contact dermatitis
    • Cause ichthyosis vulgaris
    • Genome-wide association
    • Toll-like receptor-2
    • CIS urocancic acid
    • Atopic dermatitis
    • Filaggrin gene
    • Stratum corneum
    • Epidermal differentiation

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