Edinburgh trial of screening for breast cancer: mortality at seven years

A. Huggins; B. B. Muir; P. T. Donnan; W. Hepburn; R. J. Prescott; T. A. Anderson; J. Lamb; F. E. Alexander; U. Chetty; Patrick Forrest; A. E. Kirkpatrick

doi:10.1016/0140-6736(90)90066-E

Edinburgh trial of screening for breast cancer: mortality at seven years

A. Huggins
, B. B. Muir
, P. T. Donnan
, W. Hepburn
, R. J. Prescott
, T. A. Anderson
, J. Lamb
, F. E. Alexander
, U. Chetty
, Patrick Forrest
, A. E. Kirkpatrick

Population Health and Genomics

Research output: Contribution to journal › Article › peer-review

393 Citations (Scopus)

Abstract

Between 1979 and 1981, 45130 women in Edinburgh aged 45-64 were entered into a randomised trial of breast cancer screening by mammography and clinical examination. The initial attendance rate was 61% but this varied according to age and socioeconomic status and decreased over succeeding years. The cancer detection rate was 6·2 per 1000 women attending at the first visit; the rate fell to around 3 per 1000 in the years when mammography was routinely repeated and to around 1 per 1000 at the intervening visits with clinical examination alone as the screening method. After 7 years of follow-up the mortality reduction achieved was 17% (relative risk=0·83, 95% Cl 0·58-1·18), which was not statistically significant, even when corrected for socioeconomic status. In women aged 50 years and over a mortality reduction of 20% was achieved.

Original language	English
Pages (from-to)	241-246
Number of pages	6
Journal	The Lancet
Volume	335
Issue number	8684
DOIs	https://doi.org/10.1016/0140-6736(90)90066-E
Publication status	Published - 3 Feb 1990

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0140-6736(90)90066-E

Cite this

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title = "Edinburgh trial of screening for breast cancer: mortality at seven years",

abstract = "Between 1979 and 1981, 45130 women in Edinburgh aged 45-64 were entered into a randomised trial of breast cancer screening by mammography and clinical examination. The initial attendance rate was 61\% but this varied according to age and socioeconomic status and decreased over succeeding years. The cancer detection rate was 6·2 per 1000 women attending at the first visit; the rate fell to around 3 per 1000 in the years when mammography was routinely repeated and to around 1 per 1000 at the intervening visits with clinical examination alone as the screening method. After 7 years of follow-up the mortality reduction achieved was 17\% (relative risk=0·83, 95\% Cl 0·58-1·18), which was not statistically significant, even when corrected for socioeconomic status. In women aged 50 years and over a mortality reduction of 20\% was achieved.",

author = "A. Huggins and Muir, \{B. B.\} and Donnan, \{P. T.\} and W. Hepburn and Prescott, \{R. J.\} and Anderson, \{T. A.\} and J. Lamb and Alexander, \{F. E.\} and U. Chetty and Patrick Forrest and Kirkpatrick, \{A. E.\}",

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doi = "10.1016/0140-6736(90)90066-E",

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TY - JOUR

T1 - Edinburgh trial of screening for breast cancer

T2 - mortality at seven years

AU - Huggins, A.

AU - Muir, B. B.

AU - Donnan, P. T.

AU - Hepburn, W.

AU - Prescott, R. J.

AU - Anderson, T. A.

AU - Lamb, J.

AU - Alexander, F. E.

AU - Chetty, U.

AU - Forrest, Patrick

AU - Kirkpatrick, A. E.

PY - 1990/2/3

Y1 - 1990/2/3

N2 - Between 1979 and 1981, 45130 women in Edinburgh aged 45-64 were entered into a randomised trial of breast cancer screening by mammography and clinical examination. The initial attendance rate was 61% but this varied according to age and socioeconomic status and decreased over succeeding years. The cancer detection rate was 6·2 per 1000 women attending at the first visit; the rate fell to around 3 per 1000 in the years when mammography was routinely repeated and to around 1 per 1000 at the intervening visits with clinical examination alone as the screening method. After 7 years of follow-up the mortality reduction achieved was 17% (relative risk=0·83, 95% Cl 0·58-1·18), which was not statistically significant, even when corrected for socioeconomic status. In women aged 50 years and over a mortality reduction of 20% was achieved.

AB - Between 1979 and 1981, 45130 women in Edinburgh aged 45-64 were entered into a randomised trial of breast cancer screening by mammography and clinical examination. The initial attendance rate was 61% but this varied according to age and socioeconomic status and decreased over succeeding years. The cancer detection rate was 6·2 per 1000 women attending at the first visit; the rate fell to around 3 per 1000 in the years when mammography was routinely repeated and to around 1 per 1000 at the intervening visits with clinical examination alone as the screening method. After 7 years of follow-up the mortality reduction achieved was 17% (relative risk=0·83, 95% Cl 0·58-1·18), which was not statistically significant, even when corrected for socioeconomic status. In women aged 50 years and over a mortality reduction of 20% was achieved.

UR - https://www.scopus.com/pages/publications/0025138546

U2 - 10.1016/0140-6736(90)90066-E

DO - 10.1016/0140-6736(90)90066-E

M3 - Article

C2 - 1967717

AN - SCOPUS:0025138546

SN - 0140-6736

VL - 335

SP - 241

EP - 246

JO - The Lancet

JF - The Lancet

IS - 8684

ER -

Edinburgh trial of screening for breast cancer: mortality at seven years

Abstract

ASJC Scopus subject areas

UN SDGs

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