Effect of atrial natriuretic factor on platelet function in whole blood ex-vivo in man

C. C. Lang; C. S. Lau; J. J. Belch; A. D. Struthers

doi:10.1007/BF00316102

Effect of atrial natriuretic factor on platelet function in whole blood ex-vivo in man

C. C. Lang, C. S. Lau, J. J. Belch, A. D. Struthers

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Abstract

Atrial natriuretic factor (ANF) binding sites have been shown to be present on human platelet membranes. We investigated the effect of an infusion of ANF 5 pmol.kg-1.min-1 on platelet aggregation in whole blood ex-vivo in 8 normal volunteers. Spontaneous platelet aggregation, collagen (0.6-2 micrograms.m.-1)-induced or ADP (0.5-2.0 microM)-induced aggregation was not affected by ANF. Plasma aldosterone was however significantly attenuated by ANF. These results show that a pharmacological dose of ANF does not affect platelet aggregation in man. These results suggest that the high plasma levels of ANF normally achieved in chronic heart failure or acute myocardial infarction are unlikely to contribute to the platelet hyperractivity, often observed in these conditions.

Original language	English
Pages (from-to)	589-591
Number of pages	3
Journal	European Journal of Clinical Pharmacology
Volume	39
Issue number	6
DOIs	https://doi.org/10.1007/BF00316102
Publication status	Published - 1990

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10.1007/BF00316102

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title = "Effect of atrial natriuretic factor on platelet function in whole blood ex-vivo in man",

abstract = "Atrial natriuretic factor (ANF) binding sites have been shown to be present on human platelet membranes. We investigated the effect of an infusion of ANF 5 pmol.kg-1.min-1 on platelet aggregation in whole blood ex-vivo in 8 normal volunteers. Spontaneous platelet aggregation, collagen (0.6-2 micrograms.m.-1)-induced or ADP (0.5-2.0 microM)-induced aggregation was not affected by ANF. Plasma aldosterone was however significantly attenuated by ANF. These results show that a pharmacological dose of ANF does not affect platelet aggregation in man. These results suggest that the high plasma levels of ANF normally achieved in chronic heart failure or acute myocardial infarction are unlikely to contribute to the platelet hyperractivity, often observed in these conditions.",

author = "Lang, {C. C.} and Lau, {C. S.} and Belch, {J. J.} and Struthers, {A. D.}",

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T1 - Effect of atrial natriuretic factor on platelet function in whole blood ex-vivo in man

AU - Lang, C. C.

AU - Lau, C. S.

AU - Belch, J. J.

AU - Struthers, A. D.

PY - 1990

Y1 - 1990

N2 - Atrial natriuretic factor (ANF) binding sites have been shown to be present on human platelet membranes. We investigated the effect of an infusion of ANF 5 pmol.kg-1.min-1 on platelet aggregation in whole blood ex-vivo in 8 normal volunteers. Spontaneous platelet aggregation, collagen (0.6-2 micrograms.m.-1)-induced or ADP (0.5-2.0 microM)-induced aggregation was not affected by ANF. Plasma aldosterone was however significantly attenuated by ANF. These results show that a pharmacological dose of ANF does not affect platelet aggregation in man. These results suggest that the high plasma levels of ANF normally achieved in chronic heart failure or acute myocardial infarction are unlikely to contribute to the platelet hyperractivity, often observed in these conditions.

AB - Atrial natriuretic factor (ANF) binding sites have been shown to be present on human platelet membranes. We investigated the effect of an infusion of ANF 5 pmol.kg-1.min-1 on platelet aggregation in whole blood ex-vivo in 8 normal volunteers. Spontaneous platelet aggregation, collagen (0.6-2 micrograms.m.-1)-induced or ADP (0.5-2.0 microM)-induced aggregation was not affected by ANF. Plasma aldosterone was however significantly attenuated by ANF. These results show that a pharmacological dose of ANF does not affect platelet aggregation in man. These results suggest that the high plasma levels of ANF normally achieved in chronic heart failure or acute myocardial infarction are unlikely to contribute to the platelet hyperractivity, often observed in these conditions.

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DO - 10.1007/BF00316102

M3 - Article

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SN - 0031-6970

VL - 39

SP - 589

EP - 591

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

IS - 6

ER -

Effect of atrial natriuretic factor on platelet function in whole blood ex-vivo in man

Abstract

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