Effect of atrial natriuretic factor on platelet function in whole blood ex-vivo in man

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    Abstract

    Atrial natriuretic factor (ANF) binding sites have been shown to be present on human platelet membranes. We investigated the effect of an infusion of ANF 5 pmol.kg-1.min-1 on platelet aggregation in whole blood ex-vivo in 8 normal volunteers. Spontaneous platelet aggregation, collagen (0.6-2 micrograms.m.-1)-induced or ADP (0.5-2.0 microM)-induced aggregation was not affected by ANF. Plasma aldosterone was however significantly attenuated by ANF. These results show that a pharmacological dose of ANF does not affect platelet aggregation in man. These results suggest that the high plasma levels of ANF normally achieved in chronic heart failure or acute myocardial infarction are unlikely to contribute to the platelet hyperractivity, often observed in these conditions.
    Original languageEnglish
    Pages (from-to)589-591
    Number of pages3
    JournalEuropean Journal of Clinical Pharmacology
    Volume39
    Issue number6
    DOIs
    Publication statusPublished - 1990

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