Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts

A. R. Gizatullin; N. P. Akentieva; N. A. Sanina; N. Yu Shmatko; N. S. Goryachev; N. I. Shkondina; T. R. Prichodchenko; N. Zhelev; S. M. Aldoshin

doi:10.1134/S1607672918060133

Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts

A. R. Gizatullin, N. P. Akentieva (Lead / Corresponding author), N. A. Sanina, N. Yu Shmatko, N. S. Goryachev, N. I. Shkondina, T. R. Prichodchenko, N. Zhelev, S. M. Aldoshin

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Abstract

The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.

Original language	English
Pages (from-to)	337-340
Number of pages	4
Journal	Doklady Biochemistry and Biophysics
Volume	483
Issue number	1
DOIs	https://doi.org/10.1134/S1607672918060133
Publication status	Published - Nov 2018

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title = "Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts",

abstract = "The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.",

author = "Gizatullin, {A. R.} and Akentieva, {N. P.} and Sanina, {N. A.} and Shmatko, {N. Yu} and Goryachev, {N. S.} and Shkondina, {N. I.} and Prichodchenko, {T. R.} and N. Zhelev and Aldoshin, {S. M.}",

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doi = "10.1134/S1607672918060133",

language = "English",

volume = "483",

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T1 - Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts

AU - Gizatullin, A. R.

AU - Akentieva, N. P.

AU - Sanina, N. A.

AU - Shmatko, N. Yu

AU - Goryachev, N. S.

AU - Shkondina, N. I.

AU - Prichodchenko, T. R.

AU - Zhelev, N.

AU - Aldoshin, S. M.

PY - 2018/11

Y1 - 2018/11

N2 - The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.

AB - The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.

U2 - 10.1134/S1607672918060133

DO - 10.1134/S1607672918060133

M3 - Article

C2 - 30607734

SN - 1607-6729

VL - 483

SP - 337

EP - 340

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

IS - 1

ER -

Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts

Abstract

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