Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts

A. R. Gizatullin, N. P. Akentieva (Lead / Corresponding author), N. A. Sanina, N. Yu Shmatko, N. S. Goryachev, N. I. Shkondina, T. R. Prichodchenko, N. Zhelev, S. M. Aldoshin

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Abstract

The results of the study of the effect of mononuclear dinitrosyl iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the cell viability and metabolism of human lung fibroblasts are presented, and the efficiency of their action is evaluated. It was shown that cationic DNICs increased the cell viability of fibroblasts and demonstrated the cytoprotective properties. Fluorescent analysis revealed that the DNICs compounds decrease the mitochondrial membrane potential but do not have a significant effect on the level of glutathione and reactive oxygen species in fibroblasts. It is assumed that the DNICs have the therapeutic potential for treating cardiovascular diseases.

Original languageEnglish
Pages (from-to)337-340
Number of pages4
JournalDoklady Biochemistry and Biophysics
Volume483
Issue number1
DOIs
Publication statusPublished - Nov 2018

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Gizatullin, A. R., Akentieva, N. P., Sanina, N. A., Shmatko, N. Y., Goryachev, N. S., Shkondina, N. I., Prichodchenko, T. R., Zhelev, N., & Aldoshin, S. M. (2018). Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes in Human Fibroblasts. Doklady Biochemistry and Biophysics, 483(1), 337-340. https://doi.org/10.1134/S1607672918060133