Effect of human cervical mucus on human sperm motion and hyperactivation in vitro

J. J. Zhu, C. L. R. Barratt, I. D. Cooke

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13 Citations (Scopus)

Abstract

The aim of our experiment was to examine the effect of exposure to human cervical mucus on quantitative sperm motility with specific reference to hyperactivated sperm motility. Human spermatozoa were allowed to penetrate cervical mucus for 20 min before swimming into Earle's balanced salt solution tissue culture medium for 25 min. The sperm motion characteristics were compared to those which had been obtained from a direct swim-up for 45 min. Spermatozoa treated with mucus were more 'active' than the control group. Multivariate statistical analysis indicated that cervical mucus promotes hyperactivated motility and that sperm sub-populations exposed to cervical mucus are very heterogeneous, as indicated by the numbers and motility characteristics of spermatozoa.

Original languageEnglish
Pages (from-to)1402-1406
Number of pages5
JournalHuman Reproduction
Volume7
Issue number10
DOIs
Publication statusPublished - Nov 1992

Keywords

  • Cervix Mucus/physiology
  • Cluster Analysis
  • Computers
  • Female
  • Humans
  • In Vitro Techniques
  • Male
  • Multivariate Analysis
  • Sperm Motility

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