Effect of ibuprofen on cardioprotective effect of aspirin

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    Abstract

    Treatment with ibuprofen might limit the cardioprotective effects of aspirin. We aimed to assess whether patients with known cardiovascular disease who take low-dose aspirin and ibuprofen have increased risk of cardiovascular mortality. We studied 7107 patients who were discharged after first admission for cardiovascular disease between April, 1989, and April, 1997, and who were prescribed low-dose aspirin (<325 mg/day) and survived for at least 1 month. Compared with those who used aspirin alone, patients taking aspirin plus ibuprofen had an increased risk of all-cause mortality (adjusted hazard ratio 1·93, 95% CI 1·30–2·87, p=0·0011) and cardiovascular mortality (1·73, 1·05–2·84, p=0·0305). Our finding lends support to the hypothesis that ibuprofen may interact with the cardioprotective effects of aspirin, at least in patients with established cardiovascular disease.
    Original languageEnglish
    Pages (from-to)573-574
    Number of pages2
    JournalLancet
    Volume361
    Issue number9357
    DOIs
    Publication statusPublished - Feb 2003

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