Effect of individual- and group-level antibiotic exposure on MRSA isolation: a multilevel analysis

Arno Muller, Frédéric Mauny, Daniel Talon, Peter T. Donnan, Stephan Harbarth, Xavier Bertrand (Lead / Corresponding author)

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    61 Citations (Scopus)

    Abstract

    Objectives: To observe the relative role of individual and group-level antimicrobial selective pressure on subsequent methicillin-resistant Staphylococcus aureus (MRSA) isolation in a university hospital. Methods: For this purpose, 18596 patients were included in a retrospective statistical analysis, applying multilevel modelling with discrete time intervals at the lowest level. Individual-level and hospital group variables on antimicrobial exposure and MRSA colonization pressure were collected from computerized databases. Results: The simultaneous hospital group- and individual-level analysis showed individual exposure to fluoroquinolones and collective exposure to penicillins to be associated with MRSA isolation after adjustment for colonization pressure and other potential confounders. Conclusions: These results support efforts to reduce prescriptions of selected antimicrobial drug classes such as fluoroquinolones and show the added value of multilevel analysis for research on the adverse outcomes of antibiotic prescribing.

    Original languageEnglish
    Pages (from-to)878-881
    Number of pages4
    JournalJournal of Antimicrobial Chemotherapy
    Volume58
    Issue number4
    DOIs
    Publication statusPublished - 1 Oct 2006

    Keywords

    • Antimicrobial use
    • Ecological bias
    • Individual exposure
    • Methicillin-resistant Staphylococcus aureus

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