Effect of intravenous adrenaline on electrocardiogram, blood pressure, and serum potassium

A. D. Struthers, J. L. Reid, R. Whitesmith, J. C. Rodger

    Research output: Contribution to journalArticle

    111 Citations (Scopus)

    Abstract

    Increased catecholamines after myocardial infarction may contribute to the development of arrhythmias. We have infused adrenaline intravenously in nine normal volunteers to levels similar to those seen after myocardial infarction. Adrenaline caused an increase in systolic blood pressure, a decrease in diastolic blood pressure, and an increase in heart rate. Adrenaline also produced a decrease in T wave amplitude and an increase in the QTc interval. The serum potassium fell dramatically during the adrenaline infusion from a control value of 4.06 mmol/l to 3.22 mmol/l. Hypokalaemia after myocardial infarction is associated with an increased incidence of ventricular arrhythmias. Thus, circulating adrenaline may increase the frequency of arrhythmias both directly via changes in ventricular repolarisation and indirectly via adrenaline induced hypokalaemia.
    Original languageEnglish
    Pages (from-to)90-93
    Number of pages4
    JournalBritish Heart Journal
    Volume49
    Issue number1
    DOIs
    Publication statusPublished - Jan 1983

    Fingerprint

    Epinephrine
    Potassium
    Electrocardiography
    Blood Pressure
    Serum
    Cardiac Arrhythmias
    Hypokalemia
    Myocardial Infarction
    Catecholamines
    Healthy Volunteers
    Heart Rate
    Incidence

    Cite this

    Struthers, A. D. ; Reid, J. L. ; Whitesmith, R. ; Rodger, J. C. / Effect of intravenous adrenaline on electrocardiogram, blood pressure, and serum potassium. In: British Heart Journal. 1983 ; Vol. 49, No. 1. pp. 90-93.
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    Effect of intravenous adrenaline on electrocardiogram, blood pressure, and serum potassium. / Struthers, A. D.; Reid, J. L.; Whitesmith, R.; Rodger, J. C.

    In: British Heart Journal, Vol. 49, No. 1, 01.1983, p. 90-93.

    Research output: Contribution to journalArticle

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