Long-chain polyunsaturated fatty acids (LCPUFA) are important for normal visual and brain development. Although present in human milk, LCPUFA have until recently been absent from artificial formulas, and infants may have limited ability to synthesise LCPUFA. To determine the clinical significance of this relative deficiency of LCPUFA, we undertook a randomised trial of the relation between LCPUFA supplementation and infant cognitive behaviour.
Willatts, P., Forsyth, J. S., DiModugno, M. K., Varma, S., & Colvin, M. (1998). Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age. Lancet, 352(9129), 688-691. https://doi.org/10.1016/S0140-6736(97)11374-5