Effect of metformin on epicardial adipose tissue in patients with coronary artery disease without diabetes: A cardiac MRI substudy of the MET-remodel trial

Shaween Al-Talabany; Mohapradeep Mohan; Jonathan Weir-McCall; Stephen Gandy; Jagdeep S.S. Singh; Ify R. Mordi; Fatima Baig; Anna Maria J Choy; Jacob George; J. Graeme Houston; Allan D. Struthers; Faisel Khan; Chim C. Lang

doi:10.1016/j.obmed.2021.100349

Effect of metformin on epicardial adipose tissue in patients with coronary artery disease without diabetes: A cardiac MRI substudy of the MET-remodel trial

Shaween Al-Talabany, Mohapradeep Mohan, Jonathan Weir-McCall, Stephen Gandy, Jagdeep S.S. Singh, Ify R. Mordi, Fatima Baig, Anna Maria J Choy, Jacob George, J. Graeme Houston, Allan D. Struthers, Faisel Khan, Chim C. Lang

Undergraduate Medicine

Research output: Contribution to journal › Short survey › peer-review

2 Citations (Scopus)

Abstract

Epicardial adipose tissue (EAT) is a risk factor implicated in the pathogenesis and prognosis of cardiovascular disease. Metformin has been shown to regress EAT in animal models and observational studies. In this study, we report that metformin has no effect on EAT in patients with coronary artery disease without diabetes.

Original language	English
Article number	100349
Number of pages	2
Journal	Obesity Medicine
Volume	24
Early online date	13 May 2021
DOIs	https://doi.org/10.1016/j.obmed.2021.100349
Publication status	Published - Jun 2021

Keywords

Cardiac MRI
Coronary artery disease
Epicardial adipose tissue
Metformin

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.obmed.2021.100349Licence: Elsevier User Licence

REnal and Cardiovascular Effects of SGLT2 Inhibition in Combination with Loop DiurEtics in Diabetic Patients with Chronic Heart Failure (RECEDE-CHF)
Lang, C. (Investigator), McCrimmon, R. (Investigator), Mordi, I. (Investigator), Singh, J. (Investigator) & Struthers, A. (Investigator)
British Heart Foundation
29/07/16 → 28/01/19
Project: Research
MetfoRmin and its Effects on Myocardial Dimension and Left Ventricular Hypertrophy in Normotensive Patients with Coronary Artery Disease (MET-REMODEL Trial)
George, J. (Investigator), Houston, G. (Investigator), Lang, C. (Investigator) & Struthers, A. (Investigator)
British Heart Foundation
1/10/14 → 31/12/17
Project: Research

Cite this

Al-Talabany, S., Mohan, M., Weir-McCall, J., Gandy, S., Singh, J. S. S., Mordi, I. R., Baig, F., Maria J Choy, A., George, J., Houston, J. G., Struthers, A. D., Khan, F., & Lang, C. C. (2021). Effect of metformin on epicardial adipose tissue in patients with coronary artery disease without diabetes: A cardiac MRI substudy of the MET-remodel trial. Obesity Medicine, 24, Article 100349. https://doi.org/10.1016/j.obmed.2021.100349

@article{1de9e7ceaa2f44e6b4554cff2ddbe30a,

title = "Effect of metformin on epicardial adipose tissue in patients with coronary artery disease without diabetes: A cardiac MRI substudy of the MET-remodel trial",

abstract = "Epicardial adipose tissue (EAT) is a risk factor implicated in the pathogenesis and prognosis of cardiovascular disease. Metformin has been shown to regress EAT in animal models and observational studies. In this study, we report that metformin has no effect on EAT in patients with coronary artery disease without diabetes.",

keywords = "Cardiac MRI, Coronary artery disease, Epicardial adipose tissue, Metformin",

author = "Shaween Al-Talabany and Mohapradeep Mohan and Jonathan Weir-McCall and Stephen Gandy and Singh, {Jagdeep S.S.} and Mordi, {Ify R.} and Fatima Baig and {Maria J Choy}, Anna and Jacob George and Houston, {J. Graeme} and Struthers, {Allan D.} and Faisel Khan and Lang, {Chim C.}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = jun,

doi = "10.1016/j.obmed.2021.100349",

language = "English",

volume = "24",

}

Al-Talabany, S, Mohan, M, Weir-McCall, J, Gandy, S, Singh, JSS, Mordi, IR, Baig, F, Maria J Choy, A, George, J, Houston, JG , Struthers, AD , Khan, F & Lang, CC 2021, 'Effect of metformin on epicardial adipose tissue in patients with coronary artery disease without diabetes: A cardiac MRI substudy of the MET-remodel trial', Obesity Medicine, vol. 24, 100349. https://doi.org/10.1016/j.obmed.2021.100349

TY - JOUR

T1 - Effect of metformin on epicardial adipose tissue in patients with coronary artery disease without diabetes

T2 - A cardiac MRI substudy of the MET-remodel trial

AU - Al-Talabany, Shaween

AU - Mohan, Mohapradeep

AU - Weir-McCall, Jonathan

AU - Gandy, Stephen

AU - Singh, Jagdeep S.S.

AU - Mordi, Ify R.

AU - Baig, Fatima

AU - Maria J Choy, Anna

AU - George, Jacob

AU - Houston, J. Graeme

AU - Struthers, Allan D.

AU - Khan, Faisel

AU - Lang, Chim C.

PY - 2021/6

Y1 - 2021/6

N2 - Epicardial adipose tissue (EAT) is a risk factor implicated in the pathogenesis and prognosis of cardiovascular disease. Metformin has been shown to regress EAT in animal models and observational studies. In this study, we report that metformin has no effect on EAT in patients with coronary artery disease without diabetes.

AB - Epicardial adipose tissue (EAT) is a risk factor implicated in the pathogenesis and prognosis of cardiovascular disease. Metformin has been shown to regress EAT in animal models and observational studies. In this study, we report that metformin has no effect on EAT in patients with coronary artery disease without diabetes.

KW - Cardiac MRI

KW - Coronary artery disease

KW - Epicardial adipose tissue

KW - Metformin

U2 - 10.1016/j.obmed.2021.100349

DO - 10.1016/j.obmed.2021.100349

M3 - Short survey

AN - SCOPUS:85106361082

VL - 24

JO - Obesity Medicine

JF - Obesity Medicine

M1 - 100349

ER -

Effect of metformin on epicardial adipose tissue in patients with coronary artery disease without diabetes: A cardiac MRI substudy of the MET-remodel trial

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Projects

REnal and Cardiovascular Effects of SGLT2 Inhibition in Combination with Loop DiurEtics in Diabetic Patients with Chronic Heart Failure (RECEDE-CHF)

MetfoRmin and its Effects on Myocardial Dimension and Left Ventricular Hypertrophy in Normotensive Patients with Coronary Artery Disease (MET-REMODEL Trial)

Cite this