Effect of metformin on epicardial adipose tissue in patients with coronary artery disease without diabetes: A cardiac MRI substudy of the MET-remodel trial

Shaween Al-Talabany, Mohapradeep Mohan, Jonathan Weir-McCall, Stephen Gandy, Jagdeep S.S. Singh, Ify R. Mordi, Fatima Baig, Anna Maria J Choy, Jacob George, J. Graeme Houston, Allan D. Struthers, Faisel Khan, Chim C. Lang

Research output: Contribution to journalShort surveypeer-review

Abstract

Epicardial adipose tissue (EAT) is a risk factor implicated in the pathogenesis and prognosis of cardiovascular disease. Metformin has been shown to regress EAT in animal models and observational studies. In this study, we report that metformin has no effect on EAT in patients with coronary artery disease without diabetes.

Original languageEnglish
Article number100349
Number of pages2
JournalObesity Medicine
Volume24
Early online date13 May 2021
DOIs
Publication statusPublished - Jun 2021

Keywords

  • Cardiac MRI
  • Coronary artery disease
  • Epicardial adipose tissue
  • Metformin

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