Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRLI and AFX

Y. L. Woods; G.  Rena

doi:10.1042/bst0300391

Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRLI and AFX

Y. L. Woods
, G. Rena

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

The insulin-stimulated phosphoinositide 3-kinase (PI 3-kinase)/3-phosphoinositide-dependent kinase-1 (PDK1)/protein kinase B (PKB) kinase cascade is believed to play a critical role in metabolic control and cell survival, largely mediated through PKB phosphorylation of many proteins. Recent findings demonstrate that the transcription factors FKHR (forkhead in rhabdomyosarcoma), AFX (ALL1 fused gene from chromosome X) and FKHRL1 (FKHR-like 1; termed FKHR isoforms) are phosphorylated by PKB in cells, leading to their exit from the nucleus. These exciting results suggest that FKHR isoforms may be critical effectors of PI 3-kinase/PDK1/PKB signalling in vivo.

Original language	English
Pages (from-to)	391-397
Number of pages	7
Journal	Biochemical Society Transactions
Volume	30
Issue number	4
DOIs	https://doi.org/10.1042/bst0300391
Publication status	Published - 2002
Event	676th Biochemical Society Meeting - Edinburgh, United Kingdom Duration: 8 Apr 2002 → 10 Apr 2002 http://www.biochemistry.org/Conferences/AllConferences/tabid/379/View/Conference/Filter/64/Page/35/MeetingNo/676/Default.aspx

Access to Document

10.1042/bst0300391

Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRLI and AFX
Woods, Y. L. & Rena, G., 2002.
Research output: Contribution to conference › Paper

676th Biochemical Society Meeting
Rena, G. (Participant)
8 Apr 2002 → 10 Apr 2002
Activity: Participating in or organising an event types › Participation in conference
676th Biochemical Society Meeting
Woods, Y. L. (Participant)
8 Apr 2002 → 10 Apr 2002
Activity: Participating in or organising an event types › Participation in conference

Cite this

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title = "Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRLI and AFX",

abstract = "The insulin-stimulated phosphoinositide 3-kinase (PI 3-kinase)/3-phosphoinositide-dependent kinase-1 (PDK1)/protein kinase B (PKB) kinase cascade is believed to play a critical role in metabolic control and cell survival, largely mediated through PKB phosphorylation of many proteins. Recent findings demonstrate that the transcription factors FKHR (forkhead in rhabdomyosarcoma), AFX (ALL1 fused gene from chromosome X) and FKHRL1 (FKHR-like 1; termed FKHR isoforms) are phosphorylated by PKB in cells, leading to their exit from the nucleus. These exciting results suggest that FKHR isoforms may be critical effectors of PI 3-kinase/PDK1/PKB signalling in vivo.",

author = "Woods, \{Y. L.\} and G. Rena",

year = "2002",

doi = "10.1042/bst0300391",

language = "English",

volume = "30",

pages = "391--397",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

publisher = "Portland Press",

number = "4",

note = "676th Biochemical Society Meeting ; Conference date: 08-04-2002 Through 10-04-2002",

url = "http://www.biochemistry.org/Conferences/AllConferences/tabid/379/View/Conference/Filter/64/Page/35/MeetingNo/676/Default.aspx",

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AU - Woods, Y. L.

AU - Rena, G.

PY - 2002

Y1 - 2002

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AB - The insulin-stimulated phosphoinositide 3-kinase (PI 3-kinase)/3-phosphoinositide-dependent kinase-1 (PDK1)/protein kinase B (PKB) kinase cascade is believed to play a critical role in metabolic control and cell survival, largely mediated through PKB phosphorylation of many proteins. Recent findings demonstrate that the transcription factors FKHR (forkhead in rhabdomyosarcoma), AFX (ALL1 fused gene from chromosome X) and FKHRL1 (FKHR-like 1; termed FKHR isoforms) are phosphorylated by PKB in cells, leading to their exit from the nucleus. These exciting results suggest that FKHR isoforms may be critical effectors of PI 3-kinase/PDK1/PKB signalling in vivo.

U2 - 10.1042/bst0300391

DO - 10.1042/bst0300391

M3 - Article

SN - 0300-5127

VL - 30

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EP - 397

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 4

T2 - 676th Biochemical Society Meeting

Y2 - 8 April 2002 through 10 April 2002

ER -

Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRLI and AFX

Abstract

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Research output

Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRLI and AFX

Activities

676th Biochemical Society Meeting

676th Biochemical Society Meeting

Cite this