Effect of myocardial infarction size on the simulated ECG morphology based on a 3D torso-heart model

Zhipeng Cai, Jianqing Li, Kan Luo, Zhigang Wang, Xiangyu Zhang, Jian Zhang, Chengyu Liu

    Research output: Contribution to journalConference article

    Abstract

    Objective: Myocardial infarction (MI) is a big threat to human health. Underlying linkage between changes in standard electrocardiography (ECG) waveforms and different MI conditions is important. A three-dimensional (3D) bidomain torso-heart model was proposed for stimulating the MI effect. In this study, we aimed to quantify the effect of MI size on the simulated ECG morphology from this model. Methods: Using a simplified 3D torso-heart model, the electrical activation of heart and its conduction were simulated. The adopted 3D torso-heart model consists of torso, lung, and the whole heart components, including atria, ventricles, and blood chambers. Simulation of MI was performed by changing the control parameters of the infarcted region. All infarcts were located in the anterior wall of the left ventricle. The effect of MI size (three sizes: 168.1, 914.8 and 2,210 mm3) on the QRS complex from the stimulated standard 12-lead ECGs was explored. Results: The results demonstrated the progressions of heart depolarization and repolarization and revealed the difference of electrical conduction between the normal and MI hearts. Compared with Q-wave amplitude ratios (QARs) and S-wave amplitude ratios (SARs), the R-wave amplitude ratios (RARs) showed their superiority in the distinguish of lesion size, as they are in sequential order with the lesion size. However, the cooperation of QARs and SARs can also help determine the size of infarcted myocardium, especially in the chest ECG leads. Significance: This study provided a quantitative analysis for the effect of MI size on the simulated standard 12-lead ECG morphology. The simulated results confirmed the changes in ECG QRS complex due to the MI changes are consistent with the clinical futures. Thus, it provides an alternative tool for understanding the inherent conduction mechanism of ECG signal.

    LanguageEnglish
    Pages357-360
    Number of pages4
    JournalIFMBE Proceedings
    Volume68
    Issue number2
    Early online date30 May 2018
    DOIs
    Publication statusPublished - 1 Jan 2019
    EventWorld Congress on Medical Physics and Biomedical Engineering, WC 2018 - Prague, Czech Republic
    Duration: 3 Jun 20188 Jun 2018

    Fingerprint

    Electrocardiography
    Lead
    Depolarization
    Blood
    Chemical activation
    Health
    Chemical analysis

    Keywords

    • Bidomain model
    • Electrocardiogram (ECG)
    • Myocardial infarction (MI)

    Cite this

    Cai, Zhipeng ; Li, Jianqing ; Luo, Kan ; Wang, Zhigang ; Zhang, Xiangyu ; Zhang, Jian ; Liu, Chengyu. / Effect of myocardial infarction size on the simulated ECG morphology based on a 3D torso-heart model. In: IFMBE Proceedings. 2019 ; Vol. 68, No. 2. pp. 357-360.
    @article{ef953bd0495b471e81dc097e25687059,
    title = "Effect of myocardial infarction size on the simulated ECG morphology based on a 3D torso-heart model",
    abstract = "Objective: Myocardial infarction (MI) is a big threat to human health. Underlying linkage between changes in standard electrocardiography (ECG) waveforms and different MI conditions is important. A three-dimensional (3D) bidomain torso-heart model was proposed for stimulating the MI effect. In this study, we aimed to quantify the effect of MI size on the simulated ECG morphology from this model. Methods: Using a simplified 3D torso-heart model, the electrical activation of heart and its conduction were simulated. The adopted 3D torso-heart model consists of torso, lung, and the whole heart components, including atria, ventricles, and blood chambers. Simulation of MI was performed by changing the control parameters of the infarcted region. All infarcts were located in the anterior wall of the left ventricle. The effect of MI size (three sizes: 168.1, 914.8 and 2,210 mm3) on the QRS complex from the stimulated standard 12-lead ECGs was explored. Results: The results demonstrated the progressions of heart depolarization and repolarization and revealed the difference of electrical conduction between the normal and MI hearts. Compared with Q-wave amplitude ratios (QARs) and S-wave amplitude ratios (SARs), the R-wave amplitude ratios (RARs) showed their superiority in the distinguish of lesion size, as they are in sequential order with the lesion size. However, the cooperation of QARs and SARs can also help determine the size of infarcted myocardium, especially in the chest ECG leads. Significance: This study provided a quantitative analysis for the effect of MI size on the simulated standard 12-lead ECG morphology. The simulated results confirmed the changes in ECG QRS complex due to the MI changes are consistent with the clinical futures. Thus, it provides an alternative tool for understanding the inherent conduction mechanism of ECG signal.",
    keywords = "Bidomain model, Electrocardiogram (ECG), Myocardial infarction (MI)",
    author = "Zhipeng Cai and Jianqing Li and Kan Luo and Zhigang Wang and Xiangyu Zhang and Jian Zhang and Chengyu Liu",
    note = "The project was partly supported by the National Natural Science Foundation of China (Grant Number: 61571113 and Grant Number: 61601124), International S&T Cooperation Program of China (0S2014ZR0477), the Research project of Fujian University of technology (Grant Number: GY-Z160058), the key research and development programs of Jiangsu Province (Grant Number: BE2017735), the Postgraduate Research and practice Innovation Program of Jiangsu Province (Grant Number: KYCX17_0067) and the Key Project for Science and Technology Development Fund of Nanjing Medical University (Grant Number: 2016NJMUZD038). We thank the support of the Southeast-Lenovo wearable Heart-Sleep-Emotion Intelligent Monitoring Lab.",
    year = "2019",
    month = "1",
    day = "1",
    doi = "10.1007/978-981-10-9038-7_67",
    language = "English",
    volume = "68",
    pages = "357--360",
    journal = "IFMBE Proceedings",
    issn = "1680-0737",
    publisher = "Springer Verlag",
    number = "2",

    }

    Effect of myocardial infarction size on the simulated ECG morphology based on a 3D torso-heart model. / Cai, Zhipeng; Li, Jianqing; Luo, Kan; Wang, Zhigang; Zhang, Xiangyu; Zhang, Jian; Liu, Chengyu.

    In: IFMBE Proceedings, Vol. 68, No. 2, 01.01.2019, p. 357-360.

    Research output: Contribution to journalConference article

    TY - JOUR

    T1 - Effect of myocardial infarction size on the simulated ECG morphology based on a 3D torso-heart model

    AU - Cai, Zhipeng

    AU - Li, Jianqing

    AU - Luo, Kan

    AU - Wang, Zhigang

    AU - Zhang, Xiangyu

    AU - Zhang, Jian

    AU - Liu, Chengyu

    N1 - The project was partly supported by the National Natural Science Foundation of China (Grant Number: 61571113 and Grant Number: 61601124), International S&T Cooperation Program of China (0S2014ZR0477), the Research project of Fujian University of technology (Grant Number: GY-Z160058), the key research and development programs of Jiangsu Province (Grant Number: BE2017735), the Postgraduate Research and practice Innovation Program of Jiangsu Province (Grant Number: KYCX17_0067) and the Key Project for Science and Technology Development Fund of Nanjing Medical University (Grant Number: 2016NJMUZD038). We thank the support of the Southeast-Lenovo wearable Heart-Sleep-Emotion Intelligent Monitoring Lab.

    PY - 2019/1/1

    Y1 - 2019/1/1

    N2 - Objective: Myocardial infarction (MI) is a big threat to human health. Underlying linkage between changes in standard electrocardiography (ECG) waveforms and different MI conditions is important. A three-dimensional (3D) bidomain torso-heart model was proposed for stimulating the MI effect. In this study, we aimed to quantify the effect of MI size on the simulated ECG morphology from this model. Methods: Using a simplified 3D torso-heart model, the electrical activation of heart and its conduction were simulated. The adopted 3D torso-heart model consists of torso, lung, and the whole heart components, including atria, ventricles, and blood chambers. Simulation of MI was performed by changing the control parameters of the infarcted region. All infarcts were located in the anterior wall of the left ventricle. The effect of MI size (three sizes: 168.1, 914.8 and 2,210 mm3) on the QRS complex from the stimulated standard 12-lead ECGs was explored. Results: The results demonstrated the progressions of heart depolarization and repolarization and revealed the difference of electrical conduction between the normal and MI hearts. Compared with Q-wave amplitude ratios (QARs) and S-wave amplitude ratios (SARs), the R-wave amplitude ratios (RARs) showed their superiority in the distinguish of lesion size, as they are in sequential order with the lesion size. However, the cooperation of QARs and SARs can also help determine the size of infarcted myocardium, especially in the chest ECG leads. Significance: This study provided a quantitative analysis for the effect of MI size on the simulated standard 12-lead ECG morphology. The simulated results confirmed the changes in ECG QRS complex due to the MI changes are consistent with the clinical futures. Thus, it provides an alternative tool for understanding the inherent conduction mechanism of ECG signal.

    AB - Objective: Myocardial infarction (MI) is a big threat to human health. Underlying linkage between changes in standard electrocardiography (ECG) waveforms and different MI conditions is important. A three-dimensional (3D) bidomain torso-heart model was proposed for stimulating the MI effect. In this study, we aimed to quantify the effect of MI size on the simulated ECG morphology from this model. Methods: Using a simplified 3D torso-heart model, the electrical activation of heart and its conduction were simulated. The adopted 3D torso-heart model consists of torso, lung, and the whole heart components, including atria, ventricles, and blood chambers. Simulation of MI was performed by changing the control parameters of the infarcted region. All infarcts were located in the anterior wall of the left ventricle. The effect of MI size (three sizes: 168.1, 914.8 and 2,210 mm3) on the QRS complex from the stimulated standard 12-lead ECGs was explored. Results: The results demonstrated the progressions of heart depolarization and repolarization and revealed the difference of electrical conduction between the normal and MI hearts. Compared with Q-wave amplitude ratios (QARs) and S-wave amplitude ratios (SARs), the R-wave amplitude ratios (RARs) showed their superiority in the distinguish of lesion size, as they are in sequential order with the lesion size. However, the cooperation of QARs and SARs can also help determine the size of infarcted myocardium, especially in the chest ECG leads. Significance: This study provided a quantitative analysis for the effect of MI size on the simulated standard 12-lead ECG morphology. The simulated results confirmed the changes in ECG QRS complex due to the MI changes are consistent with the clinical futures. Thus, it provides an alternative tool for understanding the inherent conduction mechanism of ECG signal.

    KW - Bidomain model

    KW - Electrocardiogram (ECG)

    KW - Myocardial infarction (MI)

    UR - http://www.scopus.com/inward/record.url?scp=85048226470&partnerID=8YFLogxK

    U2 - 10.1007/978-981-10-9038-7_67

    DO - 10.1007/978-981-10-9038-7_67

    M3 - Conference article

    VL - 68

    SP - 357

    EP - 360

    JO - IFMBE Proceedings

    T2 - IFMBE Proceedings

    JF - IFMBE Proceedings

    SN - 1680-0737

    IS - 2

    ER -