Effect of nicardipine infusion on the release of glutathione S-transferase following halothane anaesthesia

D C Ray, G J Beckett, J D Hayes, G B Drummond

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    To assess the possible protective effect of calcium channel blockade on hepatic function after halothane anaesthesia, 80 patients were allocated randomly to receive an i.v. infusion of either nicardipine or normal saline. Plasma concentration of glutathione S-transferase B1 subunits (GST) was measured as a sensitive index of hepatic damage. Data from 53 patients were analysed. Plasma GST concentration increased significantly at 3 and 6 h after induction of anaesthesia in the placebo group (P less than 0.01), and at 3 h (P less than 0.01) and 6 h (P less than 0.05) in the nicardipine group. The administration of nicardipine resulted in a greater increase in plasma GST concentrations at 3 h than did placebo (P less than 0.05), mainly because of a greater increase in males than in females. The increase in GST at 3 h was related inversely to plasma concentration of nicardipine both at the end of the exponential infusion (P less than 0.01) and at 2 h after induction (P less than 0.05), when males had lower plasma nicardipine concentrations than females (P less than 0.05). Calcium channel blockade with nicardipine in the dose administered was not shown to reduce liver dysfunction after halothane anaesthesia.

    Original languageEnglish
    Pages (from-to)553-9
    Number of pages7
    JournalBritish journal of anaesthesia
    Volume62
    Issue number5
    DOIs
    Publication statusPublished - May 1989

    Fingerprint

    Nicardipine
    Halothane
    Glutathione Transferase
    Anesthesia
    Calcium Channels
    Placebos
    Liver
    Liver Diseases

    Keywords

    • Adolescent
    • Adult
    • Aged
    • Anesthesia, Inhalation
    • Female
    • Glutathione Transferase/blood
    • Halothane
    • Humans
    • Infusions, Intravenous
    • Liver/enzymology
    • Male
    • Middle Aged
    • Nicardipine/pharmacology
    • Orthopedics
    • Random Allocation

    Cite this

    @article{0e15bcd8c9744c68993ece3075208ac5,
    title = "Effect of nicardipine infusion on the release of glutathione S-transferase following halothane anaesthesia",
    abstract = "To assess the possible protective effect of calcium channel blockade on hepatic function after halothane anaesthesia, 80 patients were allocated randomly to receive an i.v. infusion of either nicardipine or normal saline. Plasma concentration of glutathione S-transferase B1 subunits (GST) was measured as a sensitive index of hepatic damage. Data from 53 patients were analysed. Plasma GST concentration increased significantly at 3 and 6 h after induction of anaesthesia in the placebo group (P less than 0.01), and at 3 h (P less than 0.01) and 6 h (P less than 0.05) in the nicardipine group. The administration of nicardipine resulted in a greater increase in plasma GST concentrations at 3 h than did placebo (P less than 0.05), mainly because of a greater increase in males than in females. The increase in GST at 3 h was related inversely to plasma concentration of nicardipine both at the end of the exponential infusion (P less than 0.01) and at 2 h after induction (P less than 0.05), when males had lower plasma nicardipine concentrations than females (P less than 0.05). Calcium channel blockade with nicardipine in the dose administered was not shown to reduce liver dysfunction after halothane anaesthesia.",
    keywords = "Adolescent, Adult, Aged, Anesthesia, Inhalation, Female, Glutathione Transferase/blood, Halothane, Humans, Infusions, Intravenous, Liver/enzymology, Male, Middle Aged, Nicardipine/pharmacology, Orthopedics, Random Allocation",
    author = "Ray, {D C} and Beckett, {G J} and Hayes, {J D} and Drummond, {G B}",
    year = "1989",
    month = "5",
    doi = "10.1093/bja/62.5.553",
    language = "English",
    volume = "62",
    pages = "553--9",
    journal = "British Journal of Anaesthesia",
    issn = "0007-0912",
    number = "5",

    }

    Effect of nicardipine infusion on the release of glutathione S-transferase following halothane anaesthesia. / Ray, D C; Beckett, G J; Hayes, J D; Drummond, G B.

    In: British journal of anaesthesia, Vol. 62, No. 5, 05.1989, p. 553-9.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Effect of nicardipine infusion on the release of glutathione S-transferase following halothane anaesthesia

    AU - Ray, D C

    AU - Beckett, G J

    AU - Hayes, J D

    AU - Drummond, G B

    PY - 1989/5

    Y1 - 1989/5

    N2 - To assess the possible protective effect of calcium channel blockade on hepatic function after halothane anaesthesia, 80 patients were allocated randomly to receive an i.v. infusion of either nicardipine or normal saline. Plasma concentration of glutathione S-transferase B1 subunits (GST) was measured as a sensitive index of hepatic damage. Data from 53 patients were analysed. Plasma GST concentration increased significantly at 3 and 6 h after induction of anaesthesia in the placebo group (P less than 0.01), and at 3 h (P less than 0.01) and 6 h (P less than 0.05) in the nicardipine group. The administration of nicardipine resulted in a greater increase in plasma GST concentrations at 3 h than did placebo (P less than 0.05), mainly because of a greater increase in males than in females. The increase in GST at 3 h was related inversely to plasma concentration of nicardipine both at the end of the exponential infusion (P less than 0.01) and at 2 h after induction (P less than 0.05), when males had lower plasma nicardipine concentrations than females (P less than 0.05). Calcium channel blockade with nicardipine in the dose administered was not shown to reduce liver dysfunction after halothane anaesthesia.

    AB - To assess the possible protective effect of calcium channel blockade on hepatic function after halothane anaesthesia, 80 patients were allocated randomly to receive an i.v. infusion of either nicardipine or normal saline. Plasma concentration of glutathione S-transferase B1 subunits (GST) was measured as a sensitive index of hepatic damage. Data from 53 patients were analysed. Plasma GST concentration increased significantly at 3 and 6 h after induction of anaesthesia in the placebo group (P less than 0.01), and at 3 h (P less than 0.01) and 6 h (P less than 0.05) in the nicardipine group. The administration of nicardipine resulted in a greater increase in plasma GST concentrations at 3 h than did placebo (P less than 0.05), mainly because of a greater increase in males than in females. The increase in GST at 3 h was related inversely to plasma concentration of nicardipine both at the end of the exponential infusion (P less than 0.01) and at 2 h after induction (P less than 0.05), when males had lower plasma nicardipine concentrations than females (P less than 0.05). Calcium channel blockade with nicardipine in the dose administered was not shown to reduce liver dysfunction after halothane anaesthesia.

    KW - Adolescent

    KW - Adult

    KW - Aged

    KW - Anesthesia, Inhalation

    KW - Female

    KW - Glutathione Transferase/blood

    KW - Halothane

    KW - Humans

    KW - Infusions, Intravenous

    KW - Liver/enzymology

    KW - Male

    KW - Middle Aged

    KW - Nicardipine/pharmacology

    KW - Orthopedics

    KW - Random Allocation

    U2 - 10.1093/bja/62.5.553

    DO - 10.1093/bja/62.5.553

    M3 - Article

    C2 - 2730828

    VL - 62

    SP - 553

    EP - 559

    JO - British Journal of Anaesthesia

    JF - British Journal of Anaesthesia

    SN - 0007-0912

    IS - 5

    ER -