Effect of radiotherapy on oral mucosa assessed by quantitative exfoliative cytology

G.R. Ogden, J.G. Cowpe, Michael Green

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    The effect of radiotherapy on normal buccal mucosa was investigated using the quantitative techniques of cytomorphology (measurement of nuclear and cytoplasmic area) and DNA cytophotometry. These techniques were applied to smears obtained before, during, and after irradiation. Nuclear area and cytoplasmic area increased and DNA values were abnormal in most cases as a result of radiotherapy, returning to within normal limits one month after treatment. This contrasts strongly with the changes seen in smears from previously irradiated uterine cervices, where changes in cytomorphology may persist for several years.
    Original languageEnglish
    Pages (from-to)940-943
    Number of pages4
    JournalJournal of Clinical Pathology
    Volume42
    Issue number9
    DOIs
    Publication statusPublished - 1 Jan 1989

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