Effect of sympathoinhibition on exercise performance in patients with heart failure

Chim C Lang; Glenn H Rayos; Don B Chomsky; Alastair J. J. Wood; John R.  Wilson

doi:10.1161/?01.CIR.96.1.238

Effect of sympathoinhibition on exercise performance in patients with heart failure

Chim C Lang, Glenn H Rayos, Don B Chomsky, Alastair J. J. Wood, John R. Wilson

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66 Citations (Scopus)

Abstract

In patients with heart failure, excessive sympathetic activation during exercise could interfere with exercise performance by impairing arteriolar dilation in working muscle and by adversely altering skeletal muscle metabolic behavior. To test this hypothesis, we examined the effect of sympathoinhibition with clonidine, a central sympatholytic agent, on skeletal muscle blood flow and metabolism in patients with heart failure.

Original language	English
Pages (from-to)	238-45
Number of pages	8
Journal	Circulation
Volume	96
Issue number	1
DOIs	https://doi.org/10.1161/?01.CIR.96.1.238
Publication status	Published - 1997

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http://circ.ahajournals.org/content/96/1/238.full

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title = "Effect of sympathoinhibition on exercise performance in patients with heart failure",

abstract = "In patients with heart failure, excessive sympathetic activation during exercise could interfere with exercise performance by impairing arteriolar dilation in working muscle and by adversely altering skeletal muscle metabolic behavior. To test this hypothesis, we examined the effect of sympathoinhibition with clonidine, a central sympatholytic agent, on skeletal muscle blood flow and metabolism in patients with heart failure.",

author = "Lang, {Chim C} and Rayos, {Glenn H} and Chomsky, {Don B} and Wood, {Alastair J. J.} and Wilson, {John R.}",

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AU - Rayos, Glenn H

AU - Chomsky, Don B

AU - Wood, Alastair J. J.

AU - Wilson, John R.

PY - 1997

Y1 - 1997

N2 - In patients with heart failure, excessive sympathetic activation during exercise could interfere with exercise performance by impairing arteriolar dilation in working muscle and by adversely altering skeletal muscle metabolic behavior. To test this hypothesis, we examined the effect of sympathoinhibition with clonidine, a central sympatholytic agent, on skeletal muscle blood flow and metabolism in patients with heart failure.

AB - In patients with heart failure, excessive sympathetic activation during exercise could interfere with exercise performance by impairing arteriolar dilation in working muscle and by adversely altering skeletal muscle metabolic behavior. To test this hypothesis, we examined the effect of sympathoinhibition with clonidine, a central sympatholytic agent, on skeletal muscle blood flow and metabolism in patients with heart failure.

U2 - 10.1161/?01.CIR.96.1.238

DO - 10.1161/?01.CIR.96.1.238

M3 - Article

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SN - 0009-7322

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SP - 238

EP - 245

JO - Circulation

JF - Circulation

IS - 1

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Effect of sympathoinhibition on exercise performance in patients with heart failure

Abstract

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