Effect of sympathoinhibition on exercise performance in patients with heart failure

Chim C Lang, Glenn H Rayos, Don B Chomsky, Alastair J. J. Wood, John R. Wilson

    Research output: Contribution to journalArticle

    64 Citations (Scopus)

    Abstract

    In patients with heart failure, excessive sympathetic activation during exercise could interfere with exercise performance by impairing arteriolar dilation in working muscle and by adversely altering skeletal muscle metabolic behavior. To test this hypothesis, we examined the effect of sympathoinhibition with clonidine, a central sympatholytic agent, on skeletal muscle blood flow and metabolism in patients with heart failure.
    Original languageEnglish
    Pages (from-to)238-45
    Number of pages8
    JournalCirculation
    Volume96
    Issue number1
    DOIs
    Publication statusPublished - 1997

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