Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial

Phil Quirke; Robert Steele; John Monson; Robert Grieve; Subhash Khanna; Jean Couture; Chris O'Callaghan; Arthur Sun Myint; Eric Bessell; Lindsay C Thompson; Mahesh Parmar; Richard J Stephens; David Sebag-Montefiore; MRC CR07/NCIC-CTG CO16 Trial Investigators

doi:10.1016/S0140-6736(09)60485-2

Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial

Phil Quirke (Lead / Corresponding author), Robert Steele, John Monson, Robert Grieve, Subhash Khanna, Jean Couture, Chris O'Callaghan, Arthur Sun Myint, Eric Bessell, Lindsay C Thompson, Mahesh Parmar, Richard J Stephens, David Sebag-Montefiore, MRC CR07/NCIC-CTG CO16 Trial Investigators

Research output: Contribution to journal › Article › peer-review

901 Citations (Scopus)

Abstract

Local recurrence rates in operable rectal cancer are improved by radiotherapy (with or without chemotherapy) and surgical techniques such as total mesorectal excision. However, the contributions of surgery and radiotherapy to outcomes are unclear. We assessed the effect of the involvement of the circumferential resection margin and the plane of surgery achieved.

Original language	English
Pages (from-to)	821-8
Number of pages	8
Journal	Lancet
Volume	373
Issue number	9666
DOIs	https://doi.org/10.1016/S0140-6736(09)60485-2
Publication status	Published - 2009

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10.1016/S0140-6736(09)60485-2

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Quirke, P., Steele, R., Monson, J., Grieve, R., Khanna, S., Couture, J., O'Callaghan, C., Myint, A. S., Bessell, E., Thompson, L. C., Parmar, M., Stephens, R. J., Sebag-Montefiore, D., & MRC CR07/NCIC-CTG CO16 Trial Investigators (2009). Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial. Lancet, 373(9666), 821-8. https://doi.org/10.1016/S0140-6736(09)60485-2

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title = "Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial",

abstract = "Local recurrence rates in operable rectal cancer are improved by radiotherapy (with or without chemotherapy) and surgical techniques such as total mesorectal excision. However, the contributions of surgery and radiotherapy to outcomes are unclear. We assessed the effect of the involvement of the circumferential resection margin and the plane of surgery achieved.",

author = "Phil Quirke and Robert Steele and John Monson and Robert Grieve and Subhash Khanna and Jean Couture and Chris O'Callaghan and Myint, {Arthur Sun} and Eric Bessell and Thompson, {Lindsay C} and Mahesh Parmar and Stephens, {Richard J} and David Sebag-Montefiore and {MRC CR07/NCIC-CTG CO16 Trial Investigators}",

year = "2009",

doi = "10.1016/S0140-6736(09)60485-2",

language = "English",

volume = "373",

pages = "821--8",

journal = "Lancet",

issn = "0140-6736",

publisher = "Elsevier",

number = "9666",

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Quirke, P, Steele, R, Monson, J, Grieve, R, Khanna, S, Couture, J, O'Callaghan, C, Myint, AS, Bessell, E, Thompson, LC, Parmar, M, Stephens, RJ, Sebag-Montefiore, D & MRC CR07/NCIC-CTG CO16 Trial Investigators 2009, 'Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial', Lancet, vol. 373, no. 9666, pp. 821-8. https://doi.org/10.1016/S0140-6736(09)60485-2

Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial. / Quirke, Phil (Lead / Corresponding author); Steele, Robert; Monson, John et al.
In: Lancet, Vol. 373, No. 9666, 2009, p. 821-8.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer

T2 - a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial

AU - Quirke, Phil

AU - Steele, Robert

AU - Monson, John

AU - Grieve, Robert

AU - Khanna, Subhash

AU - Couture, Jean

AU - O'Callaghan, Chris

AU - Myint, Arthur Sun

AU - Bessell, Eric

AU - Thompson, Lindsay C

AU - Parmar, Mahesh

AU - Stephens, Richard J

AU - Sebag-Montefiore, David

AU - MRC CR07/NCIC-CTG CO16 Trial Investigators

PY - 2009

Y1 - 2009

N2 - Local recurrence rates in operable rectal cancer are improved by radiotherapy (with or without chemotherapy) and surgical techniques such as total mesorectal excision. However, the contributions of surgery and radiotherapy to outcomes are unclear. We assessed the effect of the involvement of the circumferential resection margin and the plane of surgery achieved.

AB - Local recurrence rates in operable rectal cancer are improved by radiotherapy (with or without chemotherapy) and surgical techniques such as total mesorectal excision. However, the contributions of surgery and radiotherapy to outcomes are unclear. We assessed the effect of the involvement of the circumferential resection margin and the plane of surgery achieved.

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U2 - 10.1016/S0140-6736(09)60485-2

DO - 10.1016/S0140-6736(09)60485-2

M3 - Article

C2 - 19269520

SN - 0140-6736

VL - 373

SP - 821

EP - 828

JO - Lancet

JF - Lancet

IS - 9666

ER -

Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial

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