Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial

Phil Quirke (Lead / Corresponding author), Robert Steele, John Monson, Robert Grieve, Subhash Khanna, Jean Couture, Chris O'Callaghan, Arthur Sun Myint, Eric Bessell, Lindsay C Thompson, Mahesh Parmar, Richard J Stephens, David Sebag-Montefiore, MRC CR07/NCIC-CTG CO16 Trial Investigators

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    658 Citations (Scopus)

    Abstract

    Local recurrence rates in operable rectal cancer are improved by radiotherapy (with or without chemotherapy) and surgical techniques such as total mesorectal excision. However, the contributions of surgery and radiotherapy to outcomes are unclear. We assessed the effect of the involvement of the circumferential resection margin and the plane of surgery achieved.
    Original languageEnglish
    Pages (from-to)821-8
    Number of pages8
    JournalLancet
    Volume373
    Issue number9666
    DOIs
    Publication statusPublished - 2009

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