Effect of vitamin D supplementation on glycaemic control and insulin resistance

a systematic review and meta-analysis

    Research output: Contribution to journalArticle

    208 Citations (Scopus)

    Abstract

    Aims To systematically review the evidence for the effect of vitaminD supplementation on glycaemia, insulin resistance, progression to diabetes and complications of diabetes. Methods Systematic review and meta-analysis. We searched databases including MEDLINE, EMBASE and the Cochrane Library for randomized controlled trials comparing vitaminD or analogues with placebo. We extracted data on fasting glucose, glycaemic control, insulin resistance, insulin/C-peptide levels, micro- and macrovascular outcomes and progression from non-diabetes to diabetes. Studies were assessed independently by two reviewers according to a pre-specified protocol. Results Fifteen trials were included in the systematic review. Trial reporting was of moderate, variable quality. Combining all studies, no significant improvement was seen in fasting glucose, HbA or insulin resistance in those treated with vitaminD compared with placebo. For patients with diabetes or impaired glucose tolerance, meta-analysis showed a small effect on fasting glucose (-0.32mmol/l, 95%CI -0.57 to -0.07) and a small improvement in insulin resistance (standard mean difference -0.25, 95%CI -0.48 to -0.03). No effect was seen on glycated haemoglobin in patients with diabetes and no differences were seen for any outcome in patients with normal fasting glucose. Insufficient data were available to draw conclusions regarding micro- or macrovascular events; two trials failed to show a reduction in new cases of diabetes in patients treated with vitaminD. Conclusions There is currently insufficient evidence of beneficial effect to recommend vitaminD supplementation as a means of improving glycaemia or insulin resistance in patients with diabetes, normal fasting glucose or impaired glucose tolerance.
    Original languageEnglish
    Pages (from-to)e142-e150
    Number of pages9
    JournalDiabetic Medicine
    Volume29
    Issue number8
    DOIs
    Publication statusPublished - 2012

    Fingerprint

    Vitamin D
    Insulin Resistance
    Meta-Analysis
    Fasting
    Glucose
    Glucose Intolerance
    Placebos
    C-Peptide
    Glycosylated Hemoglobin A
    Diabetes Complications
    MEDLINE
    Libraries
    Randomized Controlled Trials
    Databases
    Insulin

    Cite this

    @article{27830013f7c64120b6e99f123b8bf7d3,
    title = "Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis",
    abstract = "Aims To systematically review the evidence for the effect of vitaminD supplementation on glycaemia, insulin resistance, progression to diabetes and complications of diabetes. Methods Systematic review and meta-analysis. We searched databases including MEDLINE, EMBASE and the Cochrane Library for randomized controlled trials comparing vitaminD or analogues with placebo. We extracted data on fasting glucose, glycaemic control, insulin resistance, insulin/C-peptide levels, micro- and macrovascular outcomes and progression from non-diabetes to diabetes. Studies were assessed independently by two reviewers according to a pre-specified protocol. Results Fifteen trials were included in the systematic review. Trial reporting was of moderate, variable quality. Combining all studies, no significant improvement was seen in fasting glucose, HbA or insulin resistance in those treated with vitaminD compared with placebo. For patients with diabetes or impaired glucose tolerance, meta-analysis showed a small effect on fasting glucose (-0.32mmol/l, 95{\%}CI -0.57 to -0.07) and a small improvement in insulin resistance (standard mean difference -0.25, 95{\%}CI -0.48 to -0.03). No effect was seen on glycated haemoglobin in patients with diabetes and no differences were seen for any outcome in patients with normal fasting glucose. Insufficient data were available to draw conclusions regarding micro- or macrovascular events; two trials failed to show a reduction in new cases of diabetes in patients treated with vitaminD. Conclusions There is currently insufficient evidence of beneficial effect to recommend vitaminD supplementation as a means of improving glycaemia or insulin resistance in patients with diabetes, normal fasting glucose or impaired glucose tolerance.",
    author = "George, {P. S.} and Pearson, {E. R.} and Witham, {M. D.}",
    note = "Copyright 2012 Elsevier B.V., All rights reserved.",
    year = "2012",
    doi = "10.1111/j.1464-5491.2012.03672.x",
    language = "English",
    volume = "29",
    pages = "e142--e150",
    journal = "Diabetic Medicine",
    issn = "0742-3071",
    publisher = "Wiley",
    number = "8",

    }

    TY - JOUR

    T1 - Effect of vitamin D supplementation on glycaemic control and insulin resistance

    T2 - a systematic review and meta-analysis

    AU - George, P. S.

    AU - Pearson, E. R.

    AU - Witham, M. D.

    N1 - Copyright 2012 Elsevier B.V., All rights reserved.

    PY - 2012

    Y1 - 2012

    N2 - Aims To systematically review the evidence for the effect of vitaminD supplementation on glycaemia, insulin resistance, progression to diabetes and complications of diabetes. Methods Systematic review and meta-analysis. We searched databases including MEDLINE, EMBASE and the Cochrane Library for randomized controlled trials comparing vitaminD or analogues with placebo. We extracted data on fasting glucose, glycaemic control, insulin resistance, insulin/C-peptide levels, micro- and macrovascular outcomes and progression from non-diabetes to diabetes. Studies were assessed independently by two reviewers according to a pre-specified protocol. Results Fifteen trials were included in the systematic review. Trial reporting was of moderate, variable quality. Combining all studies, no significant improvement was seen in fasting glucose, HbA or insulin resistance in those treated with vitaminD compared with placebo. For patients with diabetes or impaired glucose tolerance, meta-analysis showed a small effect on fasting glucose (-0.32mmol/l, 95%CI -0.57 to -0.07) and a small improvement in insulin resistance (standard mean difference -0.25, 95%CI -0.48 to -0.03). No effect was seen on glycated haemoglobin in patients with diabetes and no differences were seen for any outcome in patients with normal fasting glucose. Insufficient data were available to draw conclusions regarding micro- or macrovascular events; two trials failed to show a reduction in new cases of diabetes in patients treated with vitaminD. Conclusions There is currently insufficient evidence of beneficial effect to recommend vitaminD supplementation as a means of improving glycaemia or insulin resistance in patients with diabetes, normal fasting glucose or impaired glucose tolerance.

    AB - Aims To systematically review the evidence for the effect of vitaminD supplementation on glycaemia, insulin resistance, progression to diabetes and complications of diabetes. Methods Systematic review and meta-analysis. We searched databases including MEDLINE, EMBASE and the Cochrane Library for randomized controlled trials comparing vitaminD or analogues with placebo. We extracted data on fasting glucose, glycaemic control, insulin resistance, insulin/C-peptide levels, micro- and macrovascular outcomes and progression from non-diabetes to diabetes. Studies were assessed independently by two reviewers according to a pre-specified protocol. Results Fifteen trials were included in the systematic review. Trial reporting was of moderate, variable quality. Combining all studies, no significant improvement was seen in fasting glucose, HbA or insulin resistance in those treated with vitaminD compared with placebo. For patients with diabetes or impaired glucose tolerance, meta-analysis showed a small effect on fasting glucose (-0.32mmol/l, 95%CI -0.57 to -0.07) and a small improvement in insulin resistance (standard mean difference -0.25, 95%CI -0.48 to -0.03). No effect was seen on glycated haemoglobin in patients with diabetes and no differences were seen for any outcome in patients with normal fasting glucose. Insufficient data were available to draw conclusions regarding micro- or macrovascular events; two trials failed to show a reduction in new cases of diabetes in patients treated with vitaminD. Conclusions There is currently insufficient evidence of beneficial effect to recommend vitaminD supplementation as a means of improving glycaemia or insulin resistance in patients with diabetes, normal fasting glucose or impaired glucose tolerance.

    UR - http://www.scopus.com/inward/record.url?scp=84863996265&partnerID=8YFLogxK

    U2 - 10.1111/j.1464-5491.2012.03672.x

    DO - 10.1111/j.1464-5491.2012.03672.x

    M3 - Article

    VL - 29

    SP - e142-e150

    JO - Diabetic Medicine

    JF - Diabetic Medicine

    SN - 0742-3071

    IS - 8

    ER -