Abstract
Background and Aims: Vitamin K insufficiency is common and linked to an increased risk of cardiovascular disease and osteoporotic fractures. The aim of this study was to examine whether daily supplementation with oral vitamin K could improve vascular health and physical function in older people with established vascular disease.
Methods and results: A double blind, randomised, placebo-controlled trial. Participants aged ≤ 70 years with a history of vascular disease were randomised to receive 6 months of daily oral 100mcg vitamin K2 (MK7 subtype) or matching placebo with outcomes measured at 0, 3 and 6 months. The primary outcome was between-group difference in endothelial function assessed using flow-mediated dilatation of the brachial artery at 6 months. Secondary outcomes included carotid-radial pulse wave velocity, augmentation index, blood pressure, carotid intima-media thickness, C-reactive protein, B-type natriuretic peptide, cholesterol and desphospho-uncarboxylated matrix Gla protein levels. Handgrip strength and the Short Physical Performance Battery assessed physical function, while postural sway was measured using a 3-dimensional force platform.
Results: 80 participants were randomised, mean age 77 (SD 5) years; 44/80 were male. Vitamin K levels rose in the intervention arm compared to placebo (+48 pg/ml vs -6 pg/ml, p=0.03) at 6 months. Desphospho-uncarboxylated Matrix Gla protein levels fell in the intervention group compared to placebo at 6 months (-130 [SD 117] pmol/L vs +13 [SD 180] pmol/L, p<0.001). No change was seen in endothelial function (between group difference -0.3% [95%CI -1.3 to 0.8], p=0.62). A modest, non-significant improvement in pulse wave velocity was seen in the vitamin K group (-0.8m/s [95%CI -1.8 to 0.3], p=0.15) while all other vascular and physical function outcomes unchanged.
Conclusions: Six months of vitamin K2 supplementation did not improve markers of vascular health or physical function in older patients with vascular disease.
| Original language | English |
|---|---|
| Pages (from-to) | 325-333 |
| Number of pages | 9 |
| Journal | Journal of Nutrition Health & Aging |
| Volume | 20 |
| Issue number | 3 |
| Early online date | 14 Nov 2015 |
| DOIs | |
| Publication status | Published - Mar 2016 |
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Keywords
- Flow mediated dilatation
- Older people
- Physical function
- Vascular health
- Vitamin K
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Effect of vitamin K on vascular health and physical function in older people with vascular disease–a randomised controlled trial. / Fulton, R. L. (Lead / Corresponding author); McMurdo, M. E. T.; Hill, A.; Abboud, R. J.; Arnold, G. P.; Struthers, A. D.; Khan, F.; Vermeer, C.; Knapen, M. H. J.; Drummen, N. E. A.; Witham, M. D.
In: Journal of Nutrition Health & Aging, Vol. 20, No. 3, 03.2016, p. 325-333.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of vitamin K on vascular health and physical function in older people with vascular disease–a randomised controlled trial
AU - Fulton, R. L.
AU - McMurdo, M. E. T.
AU - Hill, A.
AU - Abboud, R. J.
AU - Arnold, G. P.
AU - Struthers, A. D.
AU - Khan, F.
AU - Vermeer, C.
AU - Knapen, M. H. J.
AU - Drummen, N. E. A.
AU - Witham, M. D.
N1 - Chest Heart and Stroke Scotland grant R11/A137. We acknowledge the financial support of NHS Research Scotland through NHS Tayside in facilitating this research.
PY - 2016/3
Y1 - 2016/3
N2 - Background and Aims: Vitamin K insufficiency is common and linked to an increased risk of cardiovascular disease and osteoporotic fractures. The aim of this study was to examine whether daily supplementation with oral vitamin K could improve vascular health and physical function in older people with established vascular disease.Methods and results: A double blind, randomised, placebo-controlled trial. Participants aged ≤ 70 years with a history of vascular disease were randomised to receive 6 months of daily oral 100mcg vitamin K2 (MK7 subtype) or matching placebo with outcomes measured at 0, 3 and 6 months. The primary outcome was between-group difference in endothelial function assessed using flow-mediated dilatation of the brachial artery at 6 months. Secondary outcomes included carotid-radial pulse wave velocity, augmentation index, blood pressure, carotid intima-media thickness, C-reactive protein, B-type natriuretic peptide, cholesterol and desphospho-uncarboxylated matrix Gla protein levels. Handgrip strength and the Short Physical Performance Battery assessed physical function, while postural sway was measured using a 3-dimensional force platform.Results: 80 participants were randomised, mean age 77 (SD 5) years; 44/80 were male. Vitamin K levels rose in the intervention arm compared to placebo (+48 pg/ml vs -6 pg/ml, p=0.03) at 6 months. Desphospho-uncarboxylated Matrix Gla protein levels fell in the intervention group compared to placebo at 6 months (-130 [SD 117] pmol/L vs +13 [SD 180] pmol/L, p<0.001). No change was seen in endothelial function (between group difference -0.3% [95%CI -1.3 to 0.8], p=0.62). A modest, non-significant improvement in pulse wave velocity was seen in the vitamin K group (-0.8m/s [95%CI -1.8 to 0.3], p=0.15) while all other vascular and physical function outcomes unchanged.Conclusions: Six months of vitamin K2 supplementation did not improve markers of vascular health or physical function in older patients with vascular disease.
AB - Background and Aims: Vitamin K insufficiency is common and linked to an increased risk of cardiovascular disease and osteoporotic fractures. The aim of this study was to examine whether daily supplementation with oral vitamin K could improve vascular health and physical function in older people with established vascular disease.Methods and results: A double blind, randomised, placebo-controlled trial. Participants aged ≤ 70 years with a history of vascular disease were randomised to receive 6 months of daily oral 100mcg vitamin K2 (MK7 subtype) or matching placebo with outcomes measured at 0, 3 and 6 months. The primary outcome was between-group difference in endothelial function assessed using flow-mediated dilatation of the brachial artery at 6 months. Secondary outcomes included carotid-radial pulse wave velocity, augmentation index, blood pressure, carotid intima-media thickness, C-reactive protein, B-type natriuretic peptide, cholesterol and desphospho-uncarboxylated matrix Gla protein levels. Handgrip strength and the Short Physical Performance Battery assessed physical function, while postural sway was measured using a 3-dimensional force platform.Results: 80 participants were randomised, mean age 77 (SD 5) years; 44/80 were male. Vitamin K levels rose in the intervention arm compared to placebo (+48 pg/ml vs -6 pg/ml, p=0.03) at 6 months. Desphospho-uncarboxylated Matrix Gla protein levels fell in the intervention group compared to placebo at 6 months (-130 [SD 117] pmol/L vs +13 [SD 180] pmol/L, p<0.001). No change was seen in endothelial function (between group difference -0.3% [95%CI -1.3 to 0.8], p=0.62). A modest, non-significant improvement in pulse wave velocity was seen in the vitamin K group (-0.8m/s [95%CI -1.8 to 0.3], p=0.15) while all other vascular and physical function outcomes unchanged.Conclusions: Six months of vitamin K2 supplementation did not improve markers of vascular health or physical function in older patients with vascular disease.
KW - Flow mediated dilatation
KW - Older people
KW - Physical function
KW - Vascular health
KW - Vitamin K
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U2 - 10.1007/s12603-015-0619-4
DO - 10.1007/s12603-015-0619-4
M3 - Article
C2 - 26892582
VL - 20
SP - 325
EP - 333
JO - Journal of Nutrition Health & Aging
JF - Journal of Nutrition Health & Aging
SN - 1279-7707
IS - 3
ER -