Effect of vitamin K on vascular health and physical function in older people with vascular disease–a randomised controlled trial

R. L. Fulton (Lead / Corresponding author), M. E. T. McMurdo, A. Hill, R. J. Abboud, G. P. Arnold, A. D. Struthers, F. Khan, C. Vermeer, M. H. J. Knapen, N. E. A. Drummen, M. D. Witham

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background and Aims: Vitamin K insufficiency is common and linked to an increased risk of cardiovascular disease and osteoporotic fractures. The aim of this study was to examine whether daily supplementation with oral vitamin K could improve vascular health and physical function in older people with established vascular disease.

Methods and results: A double blind, randomised, placebo-controlled trial. Participants aged ≤ 70 years with a history of vascular disease were randomised to receive 6 months of daily oral 100mcg vitamin K2 (MK7 subtype) or matching placebo with outcomes measured at 0, 3 and 6 months. The primary outcome was between-group difference in endothelial function assessed using flow-mediated dilatation of the brachial artery at 6 months. Secondary outcomes included carotid-radial pulse wave velocity, augmentation index, blood pressure, carotid intima-media thickness, C-reactive protein, B-type natriuretic peptide, cholesterol and desphospho-uncarboxylated matrix Gla protein levels. Handgrip strength and the Short Physical Performance Battery assessed physical function, while postural sway was measured using a 3-dimensional force platform.

Results: 80 participants were randomised, mean age 77 (SD 5) years; 44/80 were male. Vitamin K levels rose in the intervention arm compared to placebo (+48 pg/ml vs -6 pg/ml, p=0.03) at 6 months. Desphospho-uncarboxylated Matrix Gla protein levels fell in the intervention group compared to placebo at 6 months (-130 [SD 117] pmol/L vs +13 [SD 180] pmol/L, p<0.001). No change was seen in endothelial function (between group difference -0.3% [95%CI -1.3 to 0.8], p=0.62). A modest, non-significant improvement in pulse wave velocity was seen in the vitamin K group (-0.8m/s [95%CI -1.8 to 0.3], p=0.15) while all other vascular and physical function outcomes unchanged.

Conclusions: Six months of vitamin K2 supplementation did not improve markers of vascular health or physical function in older patients with vascular disease.

Original languageEnglish
Pages (from-to)325-333
Number of pages9
JournalJournal of Nutrition Health & Aging
Volume20
Issue number3
Early online date14 Nov 2015
DOIs
Publication statusPublished - Mar 2016

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Vitamin K
Blood Vessels
Randomized Controlled Trials
Vascular Diseases
Placebos
Vitamin K 2
Pulse Wave Analysis
Health
Carotid Intima-Media Thickness
Osteoporotic Fractures
Brachial Artery
Brain Natriuretic Peptide
C-Reactive Protein
Dilatation
Cardiovascular Diseases
Cholesterol
Blood Pressure
matrix Gla protein

Keywords

  • Flow mediated dilatation
  • Older people
  • Physical function
  • Vascular health
  • Vitamin K

Cite this

Fulton, R. L. ; McMurdo, M. E. T. ; Hill, A. ; Abboud, R. J. ; Arnold, G. P. ; Struthers, A. D. ; Khan, F. ; Vermeer, C. ; Knapen, M. H. J. ; Drummen, N. E. A. ; Witham, M. D. / Effect of vitamin K on vascular health and physical function in older people with vascular disease–a randomised controlled trial. In: Journal of Nutrition Health & Aging. 2016 ; Vol. 20, No. 3. pp. 325-333.
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abstract = "Background and Aims: Vitamin K insufficiency is common and linked to an increased risk of cardiovascular disease and osteoporotic fractures. The aim of this study was to examine whether daily supplementation with oral vitamin K could improve vascular health and physical function in older people with established vascular disease.Methods and results: A double blind, randomised, placebo-controlled trial. Participants aged ≤ 70 years with a history of vascular disease were randomised to receive 6 months of daily oral 100mcg vitamin K2 (MK7 subtype) or matching placebo with outcomes measured at 0, 3 and 6 months. The primary outcome was between-group difference in endothelial function assessed using flow-mediated dilatation of the brachial artery at 6 months. Secondary outcomes included carotid-radial pulse wave velocity, augmentation index, blood pressure, carotid intima-media thickness, C-reactive protein, B-type natriuretic peptide, cholesterol and desphospho-uncarboxylated matrix Gla protein levels. Handgrip strength and the Short Physical Performance Battery assessed physical function, while postural sway was measured using a 3-dimensional force platform.Results: 80 participants were randomised, mean age 77 (SD 5) years; 44/80 were male. Vitamin K levels rose in the intervention arm compared to placebo (+48 pg/ml vs -6 pg/ml, p=0.03) at 6 months. Desphospho-uncarboxylated Matrix Gla protein levels fell in the intervention group compared to placebo at 6 months (-130 [SD 117] pmol/L vs +13 [SD 180] pmol/L, p<0.001). No change was seen in endothelial function (between group difference -0.3{\%} [95{\%}CI -1.3 to 0.8], p=0.62). A modest, non-significant improvement in pulse wave velocity was seen in the vitamin K group (-0.8m/s [95{\%}CI -1.8 to 0.3], p=0.15) while all other vascular and physical function outcomes unchanged.Conclusions: Six months of vitamin K2 supplementation did not improve markers of vascular health or physical function in older patients with vascular disease.",
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author = "Fulton, {R. L.} and McMurdo, {M. E. T.} and A. Hill and Abboud, {R. J.} and Arnold, {G. P.} and Struthers, {A. D.} and F. Khan and C. Vermeer and Knapen, {M. H. J.} and Drummen, {N. E. A.} and Witham, {M. D.}",
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Effect of vitamin K on vascular health and physical function in older people with vascular disease–a randomised controlled trial. / Fulton, R. L. (Lead / Corresponding author); McMurdo, M. E. T.; Hill, A.; Abboud, R. J.; Arnold, G. P.; Struthers, A. D.; Khan, F.; Vermeer, C.; Knapen, M. H. J.; Drummen, N. E. A.; Witham, M. D.

In: Journal of Nutrition Health & Aging, Vol. 20, No. 3, 03.2016, p. 325-333.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of vitamin K on vascular health and physical function in older people with vascular disease–a randomised controlled trial

AU - Fulton, R. L.

AU - McMurdo, M. E. T.

AU - Hill, A.

AU - Abboud, R. J.

AU - Arnold, G. P.

AU - Struthers, A. D.

AU - Khan, F.

AU - Vermeer, C.

AU - Knapen, M. H. J.

AU - Drummen, N. E. A.

AU - Witham, M. D.

N1 - Chest Heart and Stroke Scotland grant R11/A137. We acknowledge the financial support of NHS Research Scotland through NHS Tayside in facilitating this research.

PY - 2016/3

Y1 - 2016/3

N2 - Background and Aims: Vitamin K insufficiency is common and linked to an increased risk of cardiovascular disease and osteoporotic fractures. The aim of this study was to examine whether daily supplementation with oral vitamin K could improve vascular health and physical function in older people with established vascular disease.Methods and results: A double blind, randomised, placebo-controlled trial. Participants aged ≤ 70 years with a history of vascular disease were randomised to receive 6 months of daily oral 100mcg vitamin K2 (MK7 subtype) or matching placebo with outcomes measured at 0, 3 and 6 months. The primary outcome was between-group difference in endothelial function assessed using flow-mediated dilatation of the brachial artery at 6 months. Secondary outcomes included carotid-radial pulse wave velocity, augmentation index, blood pressure, carotid intima-media thickness, C-reactive protein, B-type natriuretic peptide, cholesterol and desphospho-uncarboxylated matrix Gla protein levels. Handgrip strength and the Short Physical Performance Battery assessed physical function, while postural sway was measured using a 3-dimensional force platform.Results: 80 participants were randomised, mean age 77 (SD 5) years; 44/80 were male. Vitamin K levels rose in the intervention arm compared to placebo (+48 pg/ml vs -6 pg/ml, p=0.03) at 6 months. Desphospho-uncarboxylated Matrix Gla protein levels fell in the intervention group compared to placebo at 6 months (-130 [SD 117] pmol/L vs +13 [SD 180] pmol/L, p<0.001). No change was seen in endothelial function (between group difference -0.3% [95%CI -1.3 to 0.8], p=0.62). A modest, non-significant improvement in pulse wave velocity was seen in the vitamin K group (-0.8m/s [95%CI -1.8 to 0.3], p=0.15) while all other vascular and physical function outcomes unchanged.Conclusions: Six months of vitamin K2 supplementation did not improve markers of vascular health or physical function in older patients with vascular disease.

AB - Background and Aims: Vitamin K insufficiency is common and linked to an increased risk of cardiovascular disease and osteoporotic fractures. The aim of this study was to examine whether daily supplementation with oral vitamin K could improve vascular health and physical function in older people with established vascular disease.Methods and results: A double blind, randomised, placebo-controlled trial. Participants aged ≤ 70 years with a history of vascular disease were randomised to receive 6 months of daily oral 100mcg vitamin K2 (MK7 subtype) or matching placebo with outcomes measured at 0, 3 and 6 months. The primary outcome was between-group difference in endothelial function assessed using flow-mediated dilatation of the brachial artery at 6 months. Secondary outcomes included carotid-radial pulse wave velocity, augmentation index, blood pressure, carotid intima-media thickness, C-reactive protein, B-type natriuretic peptide, cholesterol and desphospho-uncarboxylated matrix Gla protein levels. Handgrip strength and the Short Physical Performance Battery assessed physical function, while postural sway was measured using a 3-dimensional force platform.Results: 80 participants were randomised, mean age 77 (SD 5) years; 44/80 were male. Vitamin K levels rose in the intervention arm compared to placebo (+48 pg/ml vs -6 pg/ml, p=0.03) at 6 months. Desphospho-uncarboxylated Matrix Gla protein levels fell in the intervention group compared to placebo at 6 months (-130 [SD 117] pmol/L vs +13 [SD 180] pmol/L, p<0.001). No change was seen in endothelial function (between group difference -0.3% [95%CI -1.3 to 0.8], p=0.62). A modest, non-significant improvement in pulse wave velocity was seen in the vitamin K group (-0.8m/s [95%CI -1.8 to 0.3], p=0.15) while all other vascular and physical function outcomes unchanged.Conclusions: Six months of vitamin K2 supplementation did not improve markers of vascular health or physical function in older patients with vascular disease.

KW - Flow mediated dilatation

KW - Older people

KW - Physical function

KW - Vascular health

KW - Vitamin K

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