Effect of vitamin K2 on postural sway in older people who fall

A Randomized Controlled Trial

Miles D. Witham (Lead / Corresponding author), Rosemary J. G. Price, Margaret M. Band, Michael S. Hannah, Roberta L. Fulton, Clare L. Clarke, Peter T. Donnan, Paul McNamee, Vera Cvoro, Roy L. Soiza

Research output: Contribution to journalArticle

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Abstract

Objectives: Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls.

Design: Parallel-group double-blind randomized placebocontrolled trial.

Setting: Fourteen primary care practices in Scotland, UK.

Participants: A total of 95 community-dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year.

Intervention: Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year.

Measurements: The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events.

Results: Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61%) were female; 77 of 95 (81%) attended the 12-month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: −.19 cm [95% confidence interval [CI] −.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95% CI −.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95% CI −.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm.

Conclusion: Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls.
Original languageEnglish
Number of pages6
JournalJournal of the American Geriatrics Society
Early online date18 Jun 2019
DOIs
Publication statusE-pub ahead of print - 18 Jun 2019

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Vitamin K 2
Randomized Controlled Trials
Placebos
Confidence Intervals
Health Care Costs
Independent Living
Vitamin K
Scotland
Primary Health Care
Maintenance
Quality of Life
Costs and Cost Analysis
Bone and Bones
Health

Keywords

  • falls
  • health economic analysis
  • postural sway
  • recruitment
  • vitamin K

Cite this

Witham, Miles D. ; Price, Rosemary J. G. ; Band, Margaret M. ; Hannah, Michael S. ; Fulton, Roberta L. ; Clarke, Clare L. ; Donnan, Peter T. ; McNamee, Paul ; Cvoro, Vera ; Soiza, Roy L. / Effect of vitamin K2 on postural sway in older people who fall : A Randomized Controlled Trial. In: Journal of the American Geriatrics Society. 2019.
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title = "Effect of vitamin K2 on postural sway in older people who fall: A Randomized Controlled Trial",
abstract = "Objectives: Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls.Design: Parallel-group double-blind randomized placebocontrolled trial.Setting: Fourteen primary care practices in Scotland, UK.Participants: A total of 95 community-dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year.Intervention: Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year.Measurements: The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events.Results: Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61{\%}) were female; 77 of 95 (81{\%}) attended the 12-month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: −.19 cm [95{\%} confidence interval [CI] −.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95{\%} CI −.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95{\%} CI −.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm.Conclusion: Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls.",
keywords = "falls, health economic analysis, postural sway, recruitment, vitamin K",
author = "Witham, {Miles D.} and Price, {Rosemary J. G.} and Band, {Margaret M.} and Hannah, {Michael S.} and Fulton, {Roberta L.} and Clarke, {Clare L.} and Donnan, {Peter T.} and Paul McNamee and Vera Cvoro and Soiza, {Roy L.}",
note = "This work was supported by the Chief Scientist Office, Scottish Government, grant number CZH/4/1100.",
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Effect of vitamin K2 on postural sway in older people who fall : A Randomized Controlled Trial. / Witham, Miles D. (Lead / Corresponding author); Price, Rosemary J. G.; Band, Margaret M.; Hannah, Michael S.; Fulton, Roberta L.; Clarke, Clare L.; Donnan, Peter T.; McNamee, Paul; Cvoro, Vera; Soiza, Roy L.

In: Journal of the American Geriatrics Society, 18.06.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of vitamin K2 on postural sway in older people who fall

T2 - A Randomized Controlled Trial

AU - Witham, Miles D.

AU - Price, Rosemary J. G.

AU - Band, Margaret M.

AU - Hannah, Michael S.

AU - Fulton, Roberta L.

AU - Clarke, Clare L.

AU - Donnan, Peter T.

AU - McNamee, Paul

AU - Cvoro, Vera

AU - Soiza, Roy L.

N1 - This work was supported by the Chief Scientist Office, Scottish Government, grant number CZH/4/1100.

PY - 2019/6/18

Y1 - 2019/6/18

N2 - Objectives: Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls.Design: Parallel-group double-blind randomized placebocontrolled trial.Setting: Fourteen primary care practices in Scotland, UK.Participants: A total of 95 community-dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year.Intervention: Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year.Measurements: The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events.Results: Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61%) were female; 77 of 95 (81%) attended the 12-month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: −.19 cm [95% confidence interval [CI] −.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95% CI −.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95% CI −.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm.Conclusion: Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls.

AB - Objectives: Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls.Design: Parallel-group double-blind randomized placebocontrolled trial.Setting: Fourteen primary care practices in Scotland, UK.Participants: A total of 95 community-dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year.Intervention: Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year.Measurements: The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events.Results: Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61%) were female; 77 of 95 (81%) attended the 12-month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: −.19 cm [95% confidence interval [CI] −.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95% CI −.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95% CI −.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm.Conclusion: Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls.

KW - falls

KW - health economic analysis

KW - postural sway

KW - recruitment

KW - vitamin K

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U2 - 10.1111/jgs.16024

DO - 10.1111/jgs.16024

M3 - Article

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

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