Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre

Stephen Bicknell; Rekha Chaudhuri; Nicola Lee; Malcolm Shepherd; Mark Spears; Nick Pitman; Euan Cameron; Douglas Cowan; Julie Nixon; Joyce Thompson; Charles McSharry; Neil C. Thomson

doi:10.1177/1753465815601332

Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre

Stephen Bicknell, Rekha Chaudhuri (Lead / Corresponding author), Nicola Lee, Malcolm Shepherd, Mark Spears, Nick Pitman, Euan Cameron, Douglas Cowan, Julie Nixon, Joyce Thompson, Charles McSharry, Neil C. Thomson

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Published information on the effectiveness of bronchial thermoplasty (BT) for severe asthma in ‘real life’ patients is limited. We compared safety and efficacy outcomes 12 months post procedure in 10 clinic patients and 15 patients recruited to clinical trials of BT at the same centre. Baseline asthma severity was greater in the clinic group. Adverse events were similar. Clinical improvements occurred in 50% of the clinic patients compared with 73% of the research patients.

Original language	English
Pages (from-to)	267-271
Number of pages	5
Journal	Therapeutic Advances in Respiratory Disease
Volume	9
Issue number	6
DOIs	https://doi.org/10.1177/1753465815601332
Publication status	Published - 1 Dec 2015

Keywords

asthma
bronchial thermoplasty
bronchoscopy

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Pharmacology (medical)

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10.1177/1753465815601332

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Bicknell, S., Chaudhuri, R., Lee, N., Shepherd, M., Spears, M., Pitman, N., Cameron, E., Cowan, D., Nixon, J., Thompson, J., McSharry, C., & Thomson, N. C. (2015). Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre. Therapeutic Advances in Respiratory Disease, 9(6), 267-271. https://doi.org/10.1177/1753465815601332

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abstract = "Published information on the effectiveness of bronchial thermoplasty (BT) for severe asthma in {\textquoteleft}real life{\textquoteright} patients is limited. We compared safety and efficacy outcomes 12 months post procedure in 10 clinic patients and 15 patients recruited to clinical trials of BT at the same centre. Baseline asthma severity was greater in the clinic group. Adverse events were similar. Clinical improvements occurred in 50% of the clinic patients compared with 73% of the research patients.",

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Bicknell, S, Chaudhuri, R, Lee, N, Shepherd, M, Spears, M, Pitman, N, Cameron, E, Cowan, D, Nixon, J, Thompson, J, McSharry, C & Thomson, NC 2015, 'Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre', Therapeutic Advances in Respiratory Disease, vol. 9, no. 6, pp. 267-271. https://doi.org/10.1177/1753465815601332

Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre. / Bicknell, Stephen; Chaudhuri, Rekha (Lead / Corresponding author); Lee, Nicola et al.
In: Therapeutic Advances in Respiratory Disease, Vol. 9, No. 6, 01.12.2015, p. 267-271.

Research output: Contribution to journal › Article › peer-review

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T1 - Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre

AU - Bicknell, Stephen

AU - Chaudhuri, Rekha

AU - Lee, Nicola

AU - Shepherd, Malcolm

AU - Spears, Mark

AU - Pitman, Nick

AU - Cameron, Euan

AU - Cowan, Douglas

AU - Nixon, Julie

AU - Thompson, Joyce

AU - McSharry, Charles

AU - Thomson, Neil C.

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AB - Published information on the effectiveness of bronchial thermoplasty (BT) for severe asthma in ‘real life’ patients is limited. We compared safety and efficacy outcomes 12 months post procedure in 10 clinic patients and 15 patients recruited to clinical trials of BT at the same centre. Baseline asthma severity was greater in the clinic group. Adverse events were similar. Clinical improvements occurred in 50% of the clinic patients compared with 73% of the research patients.

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KW - bronchoscopy

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JO - Therapeutic Advances in Respiratory Disease

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ER -

Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre

Abstract

Keywords

ASJC Scopus subject areas

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