TY - JOUR
T1 - Effectiveness of lifestyle modification in prediabetes remission among women with isolated impaired fasting glucose
T2 - A community-based, randomised controlled trial in India
AU - Mathews, Elezebeth
AU - Nair Anand, Thakarakkattil Narayanan
AU - Joseph, Anjaly
AU - Kodapally, Bhagiaswari
AU - Pilankatta, Rajendra
AU - Narayan, K. M.Venkat
AU - Oldenburg, Brian
AU - Thankappan, Kavumpurathu Raman
N1 - Publisher Copyright:
© 2026 Elsevier B.V.
PY - 2026/2
Y1 - 2026/2
N2 - Aims: We evaluated the effectiveness of a lifestyle modification (LSM) intervention in prediabetes remission among women with isolated impaired fasting glucose (i-IFG). Methods: We conducted a community-based, parallel-group, open-label, randomised controlled trial in Kerala, India. Women aged 30–60 years with i-IFG were randomly assigned (1:1) to receive either a 12-month LSM program or standard care (diabetes information booklet). Randomization was computer-generated with allocation concealed until assignment. The primary outcome was prediabetes remission based on oral glucose tolerance testing at 12 months. Secondary outcomes included progression to type 2 diabetes and changes in glycaemic markers, anthropometric measures, body composition, and blood pressure. Analyses followed the intention-to-treat approach. Results: Of 1092 participants randomised, 1080 (98.9 %) completed the 12-month follow-up. Prediabetes remission was significantly higher in the LSM group than in controls (45.9 % vs 6.3 %; RR 7.04, 95 % CI 5.12–10.06). LSM also produced greater improvements in fasting plasma glucose (–5.2 mg/dL), HbA1c (–0.09 %), HOMA2-IR (log) (–0.38), weight (–3.7 kg), waist circumference (–1.4 cm), fat mass (–2.9 kg), and fat-free mass (+0.86 kg). The number needed to treat for prediabetes remission was 2.8 (1.8–4.0). Conclusion: A structured LSM intervention effectively promotes prediabetes remission in women with i-IFG and improves cardio metabolic health.
AB - Aims: We evaluated the effectiveness of a lifestyle modification (LSM) intervention in prediabetes remission among women with isolated impaired fasting glucose (i-IFG). Methods: We conducted a community-based, parallel-group, open-label, randomised controlled trial in Kerala, India. Women aged 30–60 years with i-IFG were randomly assigned (1:1) to receive either a 12-month LSM program or standard care (diabetes information booklet). Randomization was computer-generated with allocation concealed until assignment. The primary outcome was prediabetes remission based on oral glucose tolerance testing at 12 months. Secondary outcomes included progression to type 2 diabetes and changes in glycaemic markers, anthropometric measures, body composition, and blood pressure. Analyses followed the intention-to-treat approach. Results: Of 1092 participants randomised, 1080 (98.9 %) completed the 12-month follow-up. Prediabetes remission was significantly higher in the LSM group than in controls (45.9 % vs 6.3 %; RR 7.04, 95 % CI 5.12–10.06). LSM also produced greater improvements in fasting plasma glucose (–5.2 mg/dL), HbA1c (–0.09 %), HOMA2-IR (log) (–0.38), weight (–3.7 kg), waist circumference (–1.4 cm), fat mass (–2.9 kg), and fat-free mass (+0.86 kg). The number needed to treat for prediabetes remission was 2.8 (1.8–4.0). Conclusion: A structured LSM intervention effectively promotes prediabetes remission in women with i-IFG and improves cardio metabolic health.
KW - Isolated impaired fasting glucose
KW - Lifestyle intervention
KW - Prediabetes remission
KW - Women
UR - https://www.scopus.com/pages/publications/105027785337
U2 - 10.1016/j.diabres.2026.113106
DO - 10.1016/j.diabres.2026.113106
M3 - Article
C2 - 41539443
AN - SCOPUS:105027785337
SN - 0168-8227
VL - 232
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
M1 - 113106
ER -
