Effectiveness of two statin prescribing strategies with respect to adherence and cardiovascular outcomes

observational study

L Wei, T. M. MacDonald, A. D. Watson, M J Murphy

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Abstract

    There is considerable evidence that statins can reduce cardiovascular events. Currently high-risk patients are treated to a target cholesterol concentration. An alternative prescribing strategy (the 'fire-and-forget' approach) would instead deploy low-dose statins more widely. It has been suggested that for the same cost this approach might prevent more cardiovascular events. We have compared the treat-to-target and fire-and-forget statin prescribing strategies with respect to adherence and cardiovascular outcomes.
    Original languageEnglish
    Pages (from-to)385-392
    Number of pages8
    JournalPharmacoepidemiology and Drug Safety
    Volume16
    Issue number4
    DOIs
    Publication statusPublished - 2007

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    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Observational Studies
    Outcome Assessment (Health Care)
    Cholesterol
    Costs and Cost Analysis

    Keywords

    • Cardiovascular Diseases
    • Cholesterol
    • Cohort Studies
    • Databases as Topic
    • Drug Administration Schedule
    • Drug Prescriptions
    • Drug Utilization
    • Female
    • Follow-Up Studies
    • Humans
    • Hydroxymethylglutaryl-CoA Reductase Inhibitors
    • Hypercholesterolemia
    • Male
    • Medical Records Systems, Computerized
    • Middle Aged
    • Odds Ratio
    • Patient Compliance
    • Physician's Practice Patterns
    • Proportional Hazards Models
    • Risk Assessment
    • Scotland
    • Time Factors
    • Treatment Outcome

    Cite this

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    title = "Effectiveness of two statin prescribing strategies with respect to adherence and cardiovascular outcomes: observational study",
    abstract = "There is considerable evidence that statins can reduce cardiovascular events. Currently high-risk patients are treated to a target cholesterol concentration. An alternative prescribing strategy (the 'fire-and-forget' approach) would instead deploy low-dose statins more widely. It has been suggested that for the same cost this approach might prevent more cardiovascular events. We have compared the treat-to-target and fire-and-forget statin prescribing strategies with respect to adherence and cardiovascular outcomes.",
    keywords = "Cardiovascular Diseases, Cholesterol, Cohort Studies, Databases as Topic, Drug Administration Schedule, Drug Prescriptions, Drug Utilization, Female, Follow-Up Studies, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia, Male, Medical Records Systems, Computerized, Middle Aged, Odds Ratio, Patient Compliance, Physician's Practice Patterns, Proportional Hazards Models, Risk Assessment, Scotland, Time Factors, Treatment Outcome",
    author = "L Wei and MacDonald, {T. M.} and Watson, {A. D.} and Murphy, {M J}",
    year = "2007",
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    language = "English",
    volume = "16",
    pages = "385--392",
    journal = "Pharmacoepidemiology and Drug Safety",
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    T1 - Effectiveness of two statin prescribing strategies with respect to adherence and cardiovascular outcomes

    T2 - observational study

    AU - Wei, L

    AU - MacDonald, T. M.

    AU - Watson, A. D.

    AU - Murphy, M J

    PY - 2007

    Y1 - 2007

    N2 - There is considerable evidence that statins can reduce cardiovascular events. Currently high-risk patients are treated to a target cholesterol concentration. An alternative prescribing strategy (the 'fire-and-forget' approach) would instead deploy low-dose statins more widely. It has been suggested that for the same cost this approach might prevent more cardiovascular events. We have compared the treat-to-target and fire-and-forget statin prescribing strategies with respect to adherence and cardiovascular outcomes.

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    KW - Databases as Topic

    KW - Drug Administration Schedule

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    KW - Drug Utilization

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    KW - Follow-Up Studies

    KW - Humans

    KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors

    KW - Hypercholesterolemia

    KW - Male

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    KW - Physician's Practice Patterns

    KW - Proportional Hazards Models

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    KW - Scotland

    KW - Time Factors

    KW - Treatment Outcome

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    JO - Pharmacoepidemiology and Drug Safety

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