Effects of aldosterone and related steroids on LPS-induced increased expression of inducible NOS in rat aortic smooth muscle cells

V. Godfrey; A. L. Martin; A. D. Struthers; G. A. Lyles

doi:10.1111/j.1476-5381.2011.01523.x

Effects of aldosterone and related steroids on LPS-induced increased expression of inducible NOS in rat aortic smooth muscle cells

V. Godfrey, A. L. Martin, A. D. Struthers, G. A. Lyles

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE Expression of inducible NOS (iNOS) is important in certain inflammatory diseases. We determined if the hormone aldosterone, a mineralocorticoid receptor (MR) agonist, affects LPS activation of iNOS expression in rat aortic smooth muscle cells (RASMC).

Original language	English
Pages (from-to)	2003-2014
Number of pages	12
Journal	British Journal of Pharmacology
Volume	164
Issue number	8
DOIs	https://doi.org/10.1111/j.1476-5381.2011.01523.x
Publication status	Published - Dec 2011

Keywords

rat aorta
smooth muscle cells
nitric oxide
nitric oxide synthase
lipopolysaccharide
steroid receptors
aldosterone
spironolactone
mifepristone
eplerenone
NITRIC-OXIDE SYNTHASE
NECROSIS-FACTOR-ALPHA
NF-KAPPA-B
MINERALOCORTICOID RECEPTOR
GENE-EXPRESSION
SPIRONOLACTONE
DISEASE
LIPOPOLYSACCHARIDE
INTERLEUKIN-1-BETA
PROLIFERATION

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10.1111/j.1476-5381.2011.01523.x

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title = "Effects of aldosterone and related steroids on LPS-induced increased expression of inducible NOS in rat aortic smooth muscle cells",

abstract = "BACKGROUND AND PURPOSE Expression of inducible NOS (iNOS) is important in certain inflammatory diseases. We determined if the hormone aldosterone, a mineralocorticoid receptor (MR) agonist, affects LPS activation of iNOS expression in rat aortic smooth muscle cells (RASMC).",

keywords = "rat aorta, smooth muscle cells, nitric oxide, nitric oxide synthase, lipopolysaccharide, steroid receptors, aldosterone, spironolactone, mifepristone, eplerenone, NITRIC-OXIDE SYNTHASE, NECROSIS-FACTOR-ALPHA, NF-KAPPA-B, MINERALOCORTICOID RECEPTOR, GENE-EXPRESSION, SPIRONOLACTONE, DISEASE, LIPOPOLYSACCHARIDE, INTERLEUKIN-1-BETA, PROLIFERATION",

author = "V. Godfrey and Martin, {A. L.} and Struthers, {A. D.} and Lyles, {G. A.}",

year = "2011",

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doi = "10.1111/j.1476-5381.2011.01523.x",

language = "English",

volume = "164",

pages = "2003--2014",

journal = "British Journal of Pharmacology",

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T1 - Effects of aldosterone and related steroids on LPS-induced increased expression of inducible NOS in rat aortic smooth muscle cells

AU - Godfrey, V.

AU - Martin, A. L.

AU - Struthers, A. D.

AU - Lyles, G. A.

PY - 2011/12

Y1 - 2011/12

N2 - BACKGROUND AND PURPOSE Expression of inducible NOS (iNOS) is important in certain inflammatory diseases. We determined if the hormone aldosterone, a mineralocorticoid receptor (MR) agonist, affects LPS activation of iNOS expression in rat aortic smooth muscle cells (RASMC).

AB - BACKGROUND AND PURPOSE Expression of inducible NOS (iNOS) is important in certain inflammatory diseases. We determined if the hormone aldosterone, a mineralocorticoid receptor (MR) agonist, affects LPS activation of iNOS expression in rat aortic smooth muscle cells (RASMC).

KW - rat aorta

KW - smooth muscle cells

KW - nitric oxide

KW - nitric oxide synthase

KW - lipopolysaccharide

KW - steroid receptors

KW - aldosterone

KW - spironolactone

KW - mifepristone

KW - eplerenone

KW - NITRIC-OXIDE SYNTHASE

KW - NECROSIS-FACTOR-ALPHA

KW - NF-KAPPA-B

KW - MINERALOCORTICOID RECEPTOR

KW - GENE-EXPRESSION

KW - SPIRONOLACTONE

KW - DISEASE

KW - LIPOPOLYSACCHARIDE

KW - INTERLEUKIN-1-BETA

KW - PROLIFERATION

U2 - 10.1111/j.1476-5381.2011.01523.x

DO - 10.1111/j.1476-5381.2011.01523.x

M3 - Article

C2 - 21649641

SN - 0007-1188

VL - 164

SP - 2003

EP - 2014

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 8

ER -

Effects of aldosterone and related steroids on LPS-induced increased expression of inducible NOS in rat aortic smooth muscle cells

Abstract

Keywords

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