Effects of aldosterone and related steroids on LPS-induced increased expression of inducible NOS in rat aortic smooth muscle cells

V. Godfrey, A. L. Martin, A. D. Struthers, G. A. Lyles

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    BACKGROUND AND PURPOSE Expression of inducible NOS (iNOS) is important in certain inflammatory diseases. We determined if the hormone aldosterone, a mineralocorticoid receptor (MR) agonist, affects LPS activation of iNOS expression in rat aortic smooth muscle cells (RASMC).

    Original languageEnglish
    Pages (from-to)2003-2014
    Number of pages12
    JournalBritish Journal of Pharmacology
    Volume164
    Issue number8
    DOIs
    Publication statusPublished - Dec 2011

    Keywords

    • rat aorta
    • smooth muscle cells
    • nitric oxide
    • nitric oxide synthase
    • lipopolysaccharide
    • steroid receptors
    • aldosterone
    • spironolactone
    • mifepristone
    • eplerenone
    • NITRIC-OXIDE SYNTHASE
    • NECROSIS-FACTOR-ALPHA
    • NF-KAPPA-B
    • MINERALOCORTICOID RECEPTOR
    • GENE-EXPRESSION
    • SPIRONOLACTONE
    • DISEASE
    • LIPOPOLYSACCHARIDE
    • INTERLEUKIN-1-BETA
    • PROLIFERATION

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