Effects of aldosterone on forearm vasculature in treated chronic heart failure

Prasad Gunaruwan, Matthias Schmitt, James Sharman, Leong Lee, Allan Struthers, Michael Frenneaux

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    The nongenomic effects of aldosterone in disease states associated with endothelial dysfunction may differ from those in healthy subjects. The effects of locally infused aldosterone on the forearm blood flow and volume were studied in optimally treated patients with chronic heart failure (CHF). At baseline and after incremental intrabrachial aldosterone, forearm blood flow was assessed using conventional strain gauge plethysmography, and forearm venous volume was assessed by radionuclide plethysmography. Constriction of the resistance vasculature of the forearm without significant effect on forearm venous capacitance was demonstrated in response to aldosterone in patients treated for CHF.
    Original languageEnglish
    Pages (from-to)412-4
    Number of pages3
    JournalAmerican Journal of Cardiology
    Volume95
    Issue number3
    DOIs
    Publication statusPublished - Feb 2005

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    Aldosterone
    Forearm
    Heart Failure
    Plethysmography
    Blood Volume
    Constriction
    Radioisotopes
    Healthy Volunteers

    Cite this

    Gunaruwan, Prasad ; Schmitt, Matthias ; Sharman, James ; Lee, Leong ; Struthers, Allan ; Frenneaux, Michael. / Effects of aldosterone on forearm vasculature in treated chronic heart failure. In: American Journal of Cardiology. 2005 ; Vol. 95, No. 3. pp. 412-4.
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    abstract = "The nongenomic effects of aldosterone in disease states associated with endothelial dysfunction may differ from those in healthy subjects. The effects of locally infused aldosterone on the forearm blood flow and volume were studied in optimally treated patients with chronic heart failure (CHF). At baseline and after incremental intrabrachial aldosterone, forearm blood flow was assessed using conventional strain gauge plethysmography, and forearm venous volume was assessed by radionuclide plethysmography. Constriction of the resistance vasculature of the forearm without significant effect on forearm venous capacitance was demonstrated in response to aldosterone in patients treated for CHF.",
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    Effects of aldosterone on forearm vasculature in treated chronic heart failure. / Gunaruwan, Prasad; Schmitt, Matthias; Sharman, James; Lee, Leong; Struthers, Allan; Frenneaux, Michael.

    In: American Journal of Cardiology, Vol. 95, No. 3, 02.2005, p. 412-4.

    Research output: Contribution to journalArticle

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    T1 - Effects of aldosterone on forearm vasculature in treated chronic heart failure

    AU - Gunaruwan, Prasad

    AU - Schmitt, Matthias

    AU - Sharman, James

    AU - Lee, Leong

    AU - Struthers, Allan

    AU - Frenneaux, Michael

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