Effects of aldosterone on forearm vasculature in treated chronic heart failure

Prasad Gunaruwan, Matthias Schmitt, James Sharman, Leong Lee, Allan Struthers, Michael Frenneaux

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)


    The nongenomic effects of aldosterone in disease states associated with endothelial dysfunction may differ from those in healthy subjects. The effects of locally infused aldosterone on the forearm blood flow and volume were studied in optimally treated patients with chronic heart failure (CHF). At baseline and after incremental intrabrachial aldosterone, forearm blood flow was assessed using conventional strain gauge plethysmography, and forearm venous volume was assessed by radionuclide plethysmography. Constriction of the resistance vasculature of the forearm without significant effect on forearm venous capacitance was demonstrated in response to aldosterone in patients treated for CHF.
    Original languageEnglish
    Pages (from-to)412-4
    Number of pages3
    JournalAmerican Journal of Cardiology
    Issue number3
    Publication statusPublished - Feb 2005


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