Effects of antitumor drug sorafenib on chick embryo development

Yi Sen Cheng; Xiao-Yu Wang; Guang Wang; Yan Li; Yue-Lei Chen; Man-li Chuai; Kenneth Ka Ho Lee; Xiao-Yan Ding; Xue-song Yang

doi:10.1002/ar.23155

Effects of antitumor drug sorafenib on chick embryo development

Yi Sen Cheng, Xiao-Yu Wang, Guang Wang, Yan Li, Yue-Lei Chen, Man-li Chuai, Kenneth Ka Ho Lee, Xiao-Yan Ding (Lead / Corresponding author), Xue-song Yang (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Sorafenib has been used as an oral anti-cancer drug because of its ability to inhibit tumor growth. However, the pharmacological effect of sorafenib is still the lack of in vivo experimental evidence. Tumor and embryonic cells share some similar features, so we investigated the effects of sorafenib on the development of gastrulating chick embryos. We found that sorafenib exposure was markedly attributed to the number of embryonic cell in proliferation and apoptosis. We also detected sorafenib significantly interfered with epithelial-mesenchymal transition (EMT). Furthermore, sorafenib treatment impaired the production and migration of neural crest cells.

Original language	English
Pages (from-to)	1271-1281
Number of pages	11
Journal	Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Volume	298
Issue number	7
DOIs	https://doi.org/10.1002/ar.23155
Publication status	Published - Jul 2015

Keywords

Chick embryos
EMT
Gastrulation
Neural crest cells
Sorafenib

ASJC Scopus subject areas

Anatomy
Histology
Ecology, Evolution, Behavior and Systematics
Biotechnology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ar.23155

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abstract = "Sorafenib has been used as an oral anti-cancer drug because of its ability to inhibit tumor growth. However, the pharmacological effect of sorafenib is still the lack of in vivo experimental evidence. Tumor and embryonic cells share some similar features, so we investigated the effects of sorafenib on the development of gastrulating chick embryos. We found that sorafenib exposure was markedly attributed to the number of embryonic cell in proliferation and apoptosis. We also detected sorafenib significantly interfered with epithelial-mesenchymal transition (EMT). Furthermore, sorafenib treatment impaired the production and migration of neural crest cells.",

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author = "Cheng, {Yi Sen} and Xiao-Yu Wang and Guang Wang and Yan Li and Yue-Lei Chen and Man-li Chuai and Lee, {Kenneth Ka Ho} and Xiao-Yan Ding and Xue-song Yang",

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T1 - Effects of antitumor drug sorafenib on chick embryo development

AU - Cheng, Yi Sen

AU - Wang, Xiao-Yu

AU - Wang, Guang

AU - Li, Yan

AU - Chen, Yue-Lei

AU - Chuai, Man-li

AU - Lee, Kenneth Ka Ho

AU - Ding, Xiao-Yan

AU - Yang, Xue-song

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N2 - Sorafenib has been used as an oral anti-cancer drug because of its ability to inhibit tumor growth. However, the pharmacological effect of sorafenib is still the lack of in vivo experimental evidence. Tumor and embryonic cells share some similar features, so we investigated the effects of sorafenib on the development of gastrulating chick embryos. We found that sorafenib exposure was markedly attributed to the number of embryonic cell in proliferation and apoptosis. We also detected sorafenib significantly interfered with epithelial-mesenchymal transition (EMT). Furthermore, sorafenib treatment impaired the production and migration of neural crest cells.

AB - Sorafenib has been used as an oral anti-cancer drug because of its ability to inhibit tumor growth. However, the pharmacological effect of sorafenib is still the lack of in vivo experimental evidence. Tumor and embryonic cells share some similar features, so we investigated the effects of sorafenib on the development of gastrulating chick embryos. We found that sorafenib exposure was markedly attributed to the number of embryonic cell in proliferation and apoptosis. We also detected sorafenib significantly interfered with epithelial-mesenchymal transition (EMT). Furthermore, sorafenib treatment impaired the production and migration of neural crest cells.

KW - Chick embryos

KW - EMT

KW - Gastrulation

KW - Neural crest cells

KW - Sorafenib

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JO - Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology

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Effects of antitumor drug sorafenib on chick embryo development

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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