Effects of antitumor drug sorafenib on chick embryo development

Yi Sen Cheng, Xiao-Yu Wang, Guang Wang, Yan Li, Yue-Lei Chen, Man-li Chuai, Kenneth Ka Ho Lee, Xiao-Yan Ding (Lead / Corresponding author), Xue-song Yang (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Sorafenib has been used as an oral anti-cancer drug because of its ability to inhibit tumor growth. However, the pharmacological effect of sorafenib is still the lack of in vivo experimental evidence. Tumor and embryonic cells share some similar features, so we investigated the effects of sorafenib on the development of gastrulating chick embryos. We found that sorafenib exposure was markedly attributed to the number of embryonic cell in proliferation and apoptosis. We also detected sorafenib significantly interfered with epithelial-mesenchymal transition (EMT). Furthermore, sorafenib treatment impaired the production and migration of neural crest cells.

Original languageEnglish
Pages (from-to)1271-1281
Number of pages11
JournalAnatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Volume298
Issue number7
DOIs
Publication statusPublished - Jul 2015

Keywords

  • Chick embryos
  • EMT
  • Gastrulation
  • Neural crest cells
  • Sorafenib

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