Effects of contrast administration on cardiac MRI volumetric, flow and pulse wave velocity quantification using manual and software-based analysis

Amir Fathi, Jonathan R. Weir-McCall, Allan D. Struthers, Brian J. Lipworth, J. Graeme Houston (Lead / Corresponding author)

Research output: Contribution to journalArticle

2 Citations (Scopus)
125 Downloads (Pure)

Abstract

Objective: The aim of the current study was to determine the effects of gadolinium contrast agent on right (RV) and left ventricular (LV) volumetric, aortic flow and pulse wave velocity (PWV) quantification using manual, semi-automatic and fully automatic analysis techniques. Methods: 61 participants free from known cardiovascular disease were recruited. Cardiac MR was performed on a 3 T scanner. A balanced steady-state free precession stack was acquired of the ventricles with phase contrast imaging of the aorta performed pre- and post-administration of 10 ml 0.5 mmol ml −1 gadoterate meglumine. The images were analysed manually, and using a semi-automated and a fully automated technique. Results: 54 completed the study. Gadolinium-based contrast administration significantly increase the signal-to-noise ratio (pre: 830 ± 398 vs post: 1028 ± 540, p = 0.003) with no significant change in contrast-to-noise ratio (pre: 583 ± 302 vs post: 559 ± 346, p = 0.54). On LV analysis, post-contrast analysis yielded significantly higher end systolic volume (54 ± 20 vs 57 ± 18ml, p = 0.04), and lower ejection fraction (59 ± 9 vs 57 ± 8%, p = 0.023). On RV analysis, gadolinium contrast resulted in no significant differences. Similar results were seen using the semi-automated and fully-automated techniques but with a larger magnitude of difference. Conversely, using both manual and software analysis aortic flow and PWV quantification proved robust to the effects of contrast agent producing only small non-significant differences. Conclusion: Gadolinium contrast administration significantly alters LV endocardial contour detection with this effect amplified when using semi-automated analysis techniques. In comparison, RV and PWV analysis is robust to these effects. Advances in knowledge: Contrast administration alters LV quantification but not flow analysis. However, these differences are small.

Original languageEnglish
Article number20170717
Number of pages14
JournalBritish Journal of Radiology
Volume91
Issue number1084
Early online date22 Dec 2017
DOIs
Publication statusPublished - 2018

Fingerprint

Pulse Wave Analysis
Gadolinium
Software
Contrast Media
Signal-To-Noise Ratio
Aorta
Noise
Cardiovascular Diseases

Keywords

  • Journal article
  • Coronary Circulation
  • Reproducibility of Results
  • Pulse Wave Analysis
  • Humans
  • Middle Aged
  • Signal-To-Noise Ratio
  • Male
  • Healthy Volunteers
  • Magnetic Resonance Imaging, Cine/methods
  • Heart/diagnostic imaging
  • Female
  • Organometallic Compounds/administration & dosage
  • Contrast Media/administration & dosage
  • Image Interpretation, Computer-Assisted/methods
  • Software
  • Meglumine/administration & dosage

Cite this

@article{1a375ef7b14b4f16be459c57cc48c6a4,
title = "Effects of contrast administration on cardiac MRI volumetric, flow and pulse wave velocity quantification using manual and software-based analysis",
abstract = "Objective: The aim of the current study was to determine the effects of gadolinium contrast agent on right (RV) and left ventricular (LV) volumetric, aortic flow and pulse wave velocity (PWV) quantification using manual, semi-automatic and fully automatic analysis techniques. Methods: 61 participants free from known cardiovascular disease were recruited. Cardiac MR was performed on a 3 T scanner. A balanced steady-state free precession stack was acquired of the ventricles with phase contrast imaging of the aorta performed pre- and post-administration of 10 ml 0.5 mmol ml −1 gadoterate meglumine. The images were analysed manually, and using a semi-automated and a fully automated technique. Results: 54 completed the study. Gadolinium-based contrast administration significantly increase the signal-to-noise ratio (pre: 830 ± 398 vs post: 1028 ± 540, p = 0.003) with no significant change in contrast-to-noise ratio (pre: 583 ± 302 vs post: 559 ± 346, p = 0.54). On LV analysis, post-contrast analysis yielded significantly higher end systolic volume (54 ± 20 vs 57 ± 18ml, p = 0.04), and lower ejection fraction (59 ± 9 vs 57 ± 8{\%}, p = 0.023). On RV analysis, gadolinium contrast resulted in no significant differences. Similar results were seen using the semi-automated and fully-automated techniques but with a larger magnitude of difference. Conversely, using both manual and software analysis aortic flow and PWV quantification proved robust to the effects of contrast agent producing only small non-significant differences. Conclusion: Gadolinium contrast administration significantly alters LV endocardial contour detection with this effect amplified when using semi-automated analysis techniques. In comparison, RV and PWV analysis is robust to these effects. Advances in knowledge: Contrast administration alters LV quantification but not flow analysis. However, these differences are small.",
keywords = "Journal article, Coronary Circulation, Reproducibility of Results, Pulse Wave Analysis, Humans, Middle Aged, Signal-To-Noise Ratio, Male, Healthy Volunteers, Magnetic Resonance Imaging, Cine/methods, Heart/diagnostic imaging, Female, Organometallic Compounds/administration & dosage, Contrast Media/administration & dosage, Image Interpretation, Computer-Assisted/methods, Software, Meglumine/administration & dosage",
author = "Amir Fathi and Weir-McCall, {Jonathan R.} and Struthers, {Allan D.} and Lipworth, {Brian J.} and Houston, {J. Graeme}",
note = "JRWM is supported by the Wellcome Trust through the Scottish Translational Medicine and Therapeutics Initiative (Grant no. WT 085664) in the form of a Clinical Research Fellowship. The study was funded by Guerbet.",
year = "2018",
doi = "10.1259/bjr.20170717",
language = "English",
volume = "91",
journal = "British Journal of Radiology",
issn = "0007-1285",
publisher = "British Institute of Radiology",
number = "1084",

}

TY - JOUR

T1 - Effects of contrast administration on cardiac MRI volumetric, flow and pulse wave velocity quantification using manual and software-based analysis

AU - Fathi, Amir

AU - Weir-McCall, Jonathan R.

AU - Struthers, Allan D.

AU - Lipworth, Brian J.

AU - Houston, J. Graeme

N1 - JRWM is supported by the Wellcome Trust through the Scottish Translational Medicine and Therapeutics Initiative (Grant no. WT 085664) in the form of a Clinical Research Fellowship. The study was funded by Guerbet.

PY - 2018

Y1 - 2018

N2 - Objective: The aim of the current study was to determine the effects of gadolinium contrast agent on right (RV) and left ventricular (LV) volumetric, aortic flow and pulse wave velocity (PWV) quantification using manual, semi-automatic and fully automatic analysis techniques. Methods: 61 participants free from known cardiovascular disease were recruited. Cardiac MR was performed on a 3 T scanner. A balanced steady-state free precession stack was acquired of the ventricles with phase contrast imaging of the aorta performed pre- and post-administration of 10 ml 0.5 mmol ml −1 gadoterate meglumine. The images were analysed manually, and using a semi-automated and a fully automated technique. Results: 54 completed the study. Gadolinium-based contrast administration significantly increase the signal-to-noise ratio (pre: 830 ± 398 vs post: 1028 ± 540, p = 0.003) with no significant change in contrast-to-noise ratio (pre: 583 ± 302 vs post: 559 ± 346, p = 0.54). On LV analysis, post-contrast analysis yielded significantly higher end systolic volume (54 ± 20 vs 57 ± 18ml, p = 0.04), and lower ejection fraction (59 ± 9 vs 57 ± 8%, p = 0.023). On RV analysis, gadolinium contrast resulted in no significant differences. Similar results were seen using the semi-automated and fully-automated techniques but with a larger magnitude of difference. Conversely, using both manual and software analysis aortic flow and PWV quantification proved robust to the effects of contrast agent producing only small non-significant differences. Conclusion: Gadolinium contrast administration significantly alters LV endocardial contour detection with this effect amplified when using semi-automated analysis techniques. In comparison, RV and PWV analysis is robust to these effects. Advances in knowledge: Contrast administration alters LV quantification but not flow analysis. However, these differences are small.

AB - Objective: The aim of the current study was to determine the effects of gadolinium contrast agent on right (RV) and left ventricular (LV) volumetric, aortic flow and pulse wave velocity (PWV) quantification using manual, semi-automatic and fully automatic analysis techniques. Methods: 61 participants free from known cardiovascular disease were recruited. Cardiac MR was performed on a 3 T scanner. A balanced steady-state free precession stack was acquired of the ventricles with phase contrast imaging of the aorta performed pre- and post-administration of 10 ml 0.5 mmol ml −1 gadoterate meglumine. The images were analysed manually, and using a semi-automated and a fully automated technique. Results: 54 completed the study. Gadolinium-based contrast administration significantly increase the signal-to-noise ratio (pre: 830 ± 398 vs post: 1028 ± 540, p = 0.003) with no significant change in contrast-to-noise ratio (pre: 583 ± 302 vs post: 559 ± 346, p = 0.54). On LV analysis, post-contrast analysis yielded significantly higher end systolic volume (54 ± 20 vs 57 ± 18ml, p = 0.04), and lower ejection fraction (59 ± 9 vs 57 ± 8%, p = 0.023). On RV analysis, gadolinium contrast resulted in no significant differences. Similar results were seen using the semi-automated and fully-automated techniques but with a larger magnitude of difference. Conversely, using both manual and software analysis aortic flow and PWV quantification proved robust to the effects of contrast agent producing only small non-significant differences. Conclusion: Gadolinium contrast administration significantly alters LV endocardial contour detection with this effect amplified when using semi-automated analysis techniques. In comparison, RV and PWV analysis is robust to these effects. Advances in knowledge: Contrast administration alters LV quantification but not flow analysis. However, these differences are small.

KW - Journal article

KW - Coronary Circulation

KW - Reproducibility of Results

KW - Pulse Wave Analysis

KW - Humans

KW - Middle Aged

KW - Signal-To-Noise Ratio

KW - Male

KW - Healthy Volunteers

KW - Magnetic Resonance Imaging, Cine/methods

KW - Heart/diagnostic imaging

KW - Female

KW - Organometallic Compounds/administration & dosage

KW - Contrast Media/administration & dosage

KW - Image Interpretation, Computer-Assisted/methods

KW - Software

KW - Meglumine/administration & dosage

UR - http://www.scopus.com/inward/record.url?scp=85044693890&partnerID=8YFLogxK

U2 - 10.1259/bjr.20170717

DO - 10.1259/bjr.20170717

M3 - Article

C2 - 29271236

VL - 91

JO - British Journal of Radiology

JF - British Journal of Radiology

SN - 0007-1285

IS - 1084

M1 - 20170717

ER -