Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure

Matthias Schmitt, Prasad Gunaruwan, Nicola Payne, Justin Taylor, Leong Lee, Andrew J M Broadley, Angus K Nightingale, John R Cockcroft, Allan D Struthers, John V Tyberg, Michael P Frenneaux

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)

    Abstract

    Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects.
    Original languageEnglish
    Pages (from-to)911-7
    Number of pages7
    JournalArteriosclerosis, Thrombosis, and Vascular Biology
    Volume24
    Issue number5
    DOIs
    Publication statusPublished - 2004

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