TY - JOUR
T1 - Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure
AU - Schmitt, Matthias
AU - Gunaruwan, Prasad
AU - Payne, Nicola
AU - Taylor, Justin
AU - Lee, Leong
AU - Broadley, Andrew J M
AU - Nightingale, Angus K
AU - Cockcroft, John R
AU - Struthers, Allan D
AU - Tyberg, John V
AU - Frenneaux, Michael P
PY - 2004
Y1 - 2004
N2 - Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects.
AB - Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects.
U2 - 10.1161/01.ATV.zhq0504.7914
DO - 10.1161/01.ATV.zhq0504.7914
M3 - Article
C2 - 15001459
SN - 1524-4636
VL - 24
SP - 911
EP - 917
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
IS - 5
ER -