Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure

Matthias Schmitt; Prasad Gunaruwan; Nicola Payne; Justin Taylor; Leong Lee; Andrew J M Broadley; Angus K Nightingale; John R Cockcroft; Allan D Struthers; John V Tyberg; Michael P Frenneaux

doi:10.1161/01.ATV.zhq0504.7914

Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure

Matthias Schmitt
, Prasad Gunaruwan
, Nicola Payne
, Justin Taylor
, Leong Lee
, Andrew J M Broadley
, Angus K Nightingale
, John R Cockcroft
, Allan D Struthers
, John V Tyberg
, Michael P Frenneaux

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects.

Original language	English
Pages (from-to)	911-7
Number of pages	7
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	24
Issue number	5
DOIs	https://doi.org/10.1161/01.ATV.zhq0504.7914
Publication status	Published - 2004

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Schmitt, M., Gunaruwan, P., Payne, N., Taylor, J., Lee, L., Broadley, A. J. M., Nightingale, A. K., Cockcroft, J. R., Struthers, A. D., Tyberg, J. V., & Frenneaux, M. P. (2004). Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(5), 911-7. https://doi.org/10.1161/01.ATV.zhq0504.7914

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title = "Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure",

abstract = "Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects.",

author = "Matthias Schmitt and Prasad Gunaruwan and Nicola Payne and Justin Taylor and Leong Lee and Broadley, \{Andrew J M\} and Nightingale, \{Angus K\} and Cockcroft, \{John R\} and Struthers, \{Allan D\} and Tyberg, \{John V\} and Frenneaux, \{Michael P\}",

year = "2004",

doi = "10.1161/01.ATV.zhq0504.7914",

language = "English",

volume = "24",

pages = "911--7",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

issn = "1524-4636",

publisher = "Lippincott Williams and Wilkins",

number = "5",

}

Schmitt, M, Gunaruwan, P, Payne, N, Taylor, J, Lee, L, Broadley, AJM, Nightingale, AK, Cockcroft, JR, Struthers, AD, Tyberg, JV & Frenneaux, MP 2004, 'Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 5, pp. 911-7. https://doi.org/10.1161/01.ATV.zhq0504.7914

TY - JOUR

T1 - Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure

AU - Schmitt, Matthias

AU - Gunaruwan, Prasad

AU - Payne, Nicola

AU - Taylor, Justin

AU - Lee, Leong

AU - Broadley, Andrew J M

AU - Nightingale, Angus K

AU - Cockcroft, John R

AU - Struthers, Allan D

AU - Tyberg, John V

AU - Frenneaux, Michael P

PY - 2004

Y1 - 2004

N2 - Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects.

AB - Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects.

U2 - 10.1161/01.ATV.zhq0504.7914

DO - 10.1161/01.ATV.zhq0504.7914

M3 - Article

C2 - 15001459

SN - 1524-4636

VL - 24

SP - 911

EP - 917

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

IS - 5

ER -

Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure

Abstract

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