Effects of fixation and preservation on tissue elastic properties measured by quantitative optical coherence elastography (OCE)

Yuting Ling, Chunhui Li (Lead / Corresponding author), Kairui Feng, Robyn Duncan, Roos Eisma, Zhihong Huang, Ghulam Nabi

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Abstract

Fixed and preserved tissues have been massively used in the development of biomedical equipment and instrumentation. Not only the tissue morphology, but also its mechanical properties need to be considered in the fixation and preservation procedures since mechanical properties have significant influence on the design and performance of such instruments. Understanding the effects of storage and preservation conditions on the mechanical properties of soft tissue has both clinical and experimental significance. To this end, we aimed to study the effects of tissue preservation (by 10% formalin and Thiel fluids) on the elastic properties of five different kinds of fresh tissues from pig and chicken; specifically fat, liver, muscle, tendon and cartilage. The tissue elasticity was measured intensively and strictly within a controlled timeline of 6 months by quantitative optical coherence elastography (OCE) system. Our findings suggest that the elasticity change of tissues in the formalin solution has an ascending trend, but that of Thiel remains almost constant, providing a more real texture and properties.

Original languageEnglish
Pages (from-to)1009-1015
Number of pages7
JournalJournal of Biomechanics
Volume49
Issue number7
Early online date15 Feb 2016
DOIs
Publication statusPublished - 3 May 2016

Fingerprint

Tissue Preservation
Elasticity Imaging Techniques
Elastic Tissue
Tissue
Elasticity
Formaldehyde
Mechanical properties
Biomedical equipment
Tendons
Cartilage
Oils and fats
Chickens
Liver
Swine
Muscle
Fats
Textures
Equipment and Supplies
Muscles
Fluids

Keywords

  • Soft tissue
  • Optical coherence elastography (OCE)
  • Fixation
  • Formalin solution
  • Thiel fluids
  • Elastic properties

Cite this

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title = "Effects of fixation and preservation on tissue elastic properties measured by quantitative optical coherence elastography (OCE)",
abstract = "Fixed and preserved tissues have been massively used in the development of biomedical equipment and instrumentation. Not only the tissue morphology, but also its mechanical properties need to be considered in the fixation and preservation procedures since mechanical properties have significant influence on the design and performance of such instruments. Understanding the effects of storage and preservation conditions on the mechanical properties of soft tissue has both clinical and experimental significance. To this end, we aimed to study the effects of tissue preservation (by 10{\%} formalin and Thiel fluids) on the elastic properties of five different kinds of fresh tissues from pig and chicken; specifically fat, liver, muscle, tendon and cartilage. The tissue elasticity was measured intensively and strictly within a controlled timeline of 6 months by quantitative optical coherence elastography (OCE) system. Our findings suggest that the elasticity change of tissues in the formalin solution has an ascending trend, but that of Thiel remains almost constant, providing a more real texture and properties.",
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T1 - Effects of fixation and preservation on tissue elastic properties measured by quantitative optical coherence elastography (OCE)

AU - Ling, Yuting

AU - Li, Chunhui

AU - Feng, Kairui

AU - Duncan, Robyn

AU - Eisma, Roos

AU - Huang, Zhihong

AU - Nabi, Ghulam

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/5/3

Y1 - 2016/5/3

N2 - Fixed and preserved tissues have been massively used in the development of biomedical equipment and instrumentation. Not only the tissue morphology, but also its mechanical properties need to be considered in the fixation and preservation procedures since mechanical properties have significant influence on the design and performance of such instruments. Understanding the effects of storage and preservation conditions on the mechanical properties of soft tissue has both clinical and experimental significance. To this end, we aimed to study the effects of tissue preservation (by 10% formalin and Thiel fluids) on the elastic properties of five different kinds of fresh tissues from pig and chicken; specifically fat, liver, muscle, tendon and cartilage. The tissue elasticity was measured intensively and strictly within a controlled timeline of 6 months by quantitative optical coherence elastography (OCE) system. Our findings suggest that the elasticity change of tissues in the formalin solution has an ascending trend, but that of Thiel remains almost constant, providing a more real texture and properties.

AB - Fixed and preserved tissues have been massively used in the development of biomedical equipment and instrumentation. Not only the tissue morphology, but also its mechanical properties need to be considered in the fixation and preservation procedures since mechanical properties have significant influence on the design and performance of such instruments. Understanding the effects of storage and preservation conditions on the mechanical properties of soft tissue has both clinical and experimental significance. To this end, we aimed to study the effects of tissue preservation (by 10% formalin and Thiel fluids) on the elastic properties of five different kinds of fresh tissues from pig and chicken; specifically fat, liver, muscle, tendon and cartilage. The tissue elasticity was measured intensively and strictly within a controlled timeline of 6 months by quantitative optical coherence elastography (OCE) system. Our findings suggest that the elasticity change of tissues in the formalin solution has an ascending trend, but that of Thiel remains almost constant, providing a more real texture and properties.

KW - Soft tissue

KW - Optical coherence elastography (OCE)

KW - Fixation

KW - Formalin solution

KW - Thiel fluids

KW - Elastic properties

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