Effects of hydrocortisone on acute β-adrenoceptor blocker and histamine induced bronchoconstriction

Philip M. Short, Peter A. Williamson, Brian J. Lipworth

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    ß-adrenoceptor blockers are avoided in asthma due to concerns of bronchoconstriction. We investigated the safety of acute exposure to propranolol in asthmatics, sequentially challenged with histamine to mimic an asthma exacerbation and evaluated the role of intravenous hydrocortisone in potentiating salbutamol reversibility.
    Original languageEnglish
    Pages (from-to)717-726
    Number of pages10
    JournalBritish Journal of Clinical Pharmacology
    Volume73
    Issue number5
    DOIs
    Publication statusPublished - May 2012

    Cite this

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    title = "Effects of hydrocortisone on acute β-adrenoceptor blocker and histamine induced bronchoconstriction",
    abstract = "{\ss}-adrenoceptor blockers are avoided in asthma due to concerns of bronchoconstriction. We investigated the safety of acute exposure to propranolol in asthmatics, sequentially challenged with histamine to mimic an asthma exacerbation and evaluated the role of intravenous hydrocortisone in potentiating salbutamol reversibility.",
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    Effects of hydrocortisone on acute β-adrenoceptor blocker and histamine induced bronchoconstriction. / Short, Philip M.; Williamson, Peter A.; Lipworth, Brian J.

    In: British Journal of Clinical Pharmacology, Vol. 73, No. 5, 05.2012, p. 717-726.

    Research output: Contribution to journalArticle

    TY - JOUR

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    AU - Short, Philip M.

    AU - Williamson, Peter A.

    AU - Lipworth, Brian J.

    N1 - © 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society.

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    N2 - ß-adrenoceptor blockers are avoided in asthma due to concerns of bronchoconstriction. We investigated the safety of acute exposure to propranolol in asthmatics, sequentially challenged with histamine to mimic an asthma exacerbation and evaluated the role of intravenous hydrocortisone in potentiating salbutamol reversibility.

    AB - ß-adrenoceptor blockers are avoided in asthma due to concerns of bronchoconstriction. We investigated the safety of acute exposure to propranolol in asthmatics, sequentially challenged with histamine to mimic an asthma exacerbation and evaluated the role of intravenous hydrocortisone in potentiating salbutamol reversibility.

    U2 - 10.1111/j.1365-2125.2011.04143.x

    DO - 10.1111/j.1365-2125.2011.04143.x

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    JO - British Journal of Clinical Pharmacology

    JF - British Journal of Clinical Pharmacology

    SN - 0306-5251

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