Effects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocity

Jonathan R. Weir-McCall; Faisel Khan; Deirdre B. Cassidy; Arsh Thakur; Jennifer Summersgill; Shona Z. Matthew; Fiona Adams; Fiona Dove; Stephen J. Gandy; Helen M. Colhoun; Jill J. F. Belch; J. Graeme Houston

doi:10.1186/s12872-017-0546-x

Effects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocity

Jonathan R. Weir-McCall, Faisel Khan (Lead / Corresponding author), Deirdre B. Cassidy, Arsh Thakur, Jennifer Summersgill, Shona Z. Matthew, Fiona Adams, Fiona Dove, Stephen J. Gandy, Helen M. Colhoun, Jill J. F. Belch, J. Graeme Houston (Lead / Corresponding author)

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Abstract

Background: Carotid-femoral pulse wave velocity (cf-PWV) and aortic PWV measured using MRI (MRI-PWV) show good correlation, but with a significant and consistent bias across studies. The aim of the current study was to evaluate whether the differences between cf-PWV and MRI-PWV can be accounted for by inaccuracies of currently used distance measurements.

Methods: 114 study participants were recruited into one of 4 groups: Type 2 diabetes melltus (T2DM) with cardiovascular disease (CVD) (n=23), T2DM without CVD (n=41), CVD without T2DM (n=25) and a control group (n=25). All participants underwent cf-PWV, cardiac MRI and whole body MR angiography(WB-MRA). 90 study participants also underwent aortic PWV using MRI. cf-PWVEXT was performed using a SphygmoCor device (Atcor Medical, West Ryde, Australia). The true intra-arterial pathlength was measured using the WB-MRA and then used to recalculate the cf-PWVEXT to give a cf-PWVMRA.

Results: Distance measurements were significantly lower on WB-MRA than on external tape measure (mean diff = -85.4 ± 54.0mm,p<0.001). MRI-PWV was significantly lower than cf-PWVEXT (MRI-PWV= 8.1 ± 2.9 vs. cf-PWVEXT =10.9 ± 2.7ms-1,p<0.001). When cf-PWV was recalculated using the inter-arterial distance from WB-MRA, this difference was significantly reduced but not lost (MRI-PWV=8.1 ± 2.9ms-1 vs. cf-PWVMRA 9.1 ± 2.1 ms-1, mean diff = -0.96±2.52ms-1,p=0.001). Recalculation of the PWV increased correlation with age and pulse pressure.
Conclusion: Differences in cf-PWV and MRI PWV can be predominantly but not entirely explained by inaccuracies introduced by the use of simple surface measurements to represent the convoluted arterial path between the carotid and femoral arteries.

Original language	English
Article number	118
Pages (from-to)	1-9
Number of pages	9
Journal	BMC Cardiovascular Disorders
Volume	17
DOIs	https://doi.org/10.1186/s12872-017-0546-x
Publication status	Published - 10 May 2017

Keywords

arteriosclerosis
MRI
PWV
Diabetes
Cardiovascular

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© The Author(s). 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Chest Heart & Stroke (Scotland) TASCFORCE
Belch, J. (Creator), University of Dundee, 2024
https://www.dundee.ac.uk/hic/data-service/dataset-inventory
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Cite this

Weir-McCall, J. R., Khan, F., Cassidy, D. B., Thakur, A., Summersgill, J., Matthew, S. Z., Adams, F., Dove, F., Gandy, S. J., Colhoun, H. M., Belch, J. J. F., & Houston, J. G. (2017). Effects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocity. BMC Cardiovascular Disorders, 17, 1-9. Article 118. https://doi.org/10.1186/s12872-017-0546-x

@article{d88ff1cb7c624c74ac8d29a164e1448b,

title = "Effects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocity",

abstract = "Background: Carotid-femoral pulse wave velocity (cf-PWV) and aortic PWV measured using MRI (MRI-PWV) show good correlation, but with a significant and consistent bias across studies. The aim of the current study was to evaluate whether the differences between cf-PWV and MRI-PWV can be accounted for by inaccuracies of currently used distance measurements.Methods: 114 study participants were recruited into one of 4 groups: Type 2 diabetes melltus (T2DM) with cardiovascular disease (CVD) (n=23), T2DM without CVD (n=41), CVD without T2DM (n=25) and a control group (n=25). All participants underwent cf-PWV, cardiac MRI and whole body MR angiography(WB-MRA). 90 study participants also underwent aortic PWV using MRI. cf-PWVEXT was performed using a SphygmoCor device (Atcor Medical, West Ryde, Australia). The true intra-arterial pathlength was measured using the WB-MRA and then used to recalculate the cf-PWVEXT to give a cf-PWVMRA.Results: Distance measurements were significantly lower on WB-MRA than on external tape measure (mean diff = -85.4 ± 54.0mm,p<0.001). MRI-PWV was significantly lower than cf-PWVEXT (MRI-PWV= 8.1 ± 2.9 vs. cf-PWVEXT =10.9 ± 2.7ms-1,p<0.001). When cf-PWV was recalculated using the inter-arterial distance from WB-MRA, this difference was significantly reduced but not lost (MRI-PWV=8.1 ± 2.9ms-1 vs. cf-PWVMRA 9.1 ± 2.1 ms-1, mean diff = -0.96±2.52ms-1,p=0.001). Recalculation of the PWV increased correlation with age and pulse pressure.Conclusion: Differences in cf-PWV and MRI PWV can be predominantly but not entirely explained by inaccuracies introduced by the use of simple surface measurements to represent the convoluted arterial path between the carotid and femoral arteries.",

keywords = "arteriosclerosis, MRI, PWV, Diabetes, Cardiovascular",

author = "Weir-McCall, {Jonathan R.} and Faisel Khan and Cassidy, {Deirdre B.} and Arsh Thakur and Jennifer Summersgill and Matthew, {Shona Z.} and Fiona Adams and Fiona Dove and Gandy, {Stephen J.} and Colhoun, {Helen M.} and Belch, {Jill J. F.} and Houston, {J. Graeme}",

note = "Wellcome Trust (WT 085664).",

year = "2017",

month = may,

day = "10",

doi = "10.1186/s12872-017-0546-x",

language = "English",

volume = "17",

pages = "1--9",

journal = "BMC Cardiovascular Disorders",

issn = "1471-2261",

publisher = "Springer Verlag",

}

Weir-McCall, JR, Khan, F, Cassidy, DB, Thakur, A, Summersgill, J, Matthew, SZ, Adams, F, Dove, F, Gandy, SJ, Colhoun, HM, Belch, JJF & Houston, JG 2017, 'Effects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocity', BMC Cardiovascular Disorders, vol. 17, 118, pp. 1-9. https://doi.org/10.1186/s12872-017-0546-x

TY - JOUR

T1 - Effects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocity

AU - Weir-McCall, Jonathan R.

AU - Khan, Faisel

AU - Cassidy, Deirdre B.

AU - Thakur, Arsh

AU - Summersgill, Jennifer

AU - Matthew, Shona Z.

AU - Adams, Fiona

AU - Dove, Fiona

AU - Gandy, Stephen J.

AU - Colhoun, Helen M.

AU - Belch, Jill J. F.

AU - Houston, J. Graeme

N1 - Wellcome Trust (WT 085664).

PY - 2017/5/10

Y1 - 2017/5/10

N2 - Background: Carotid-femoral pulse wave velocity (cf-PWV) and aortic PWV measured using MRI (MRI-PWV) show good correlation, but with a significant and consistent bias across studies. The aim of the current study was to evaluate whether the differences between cf-PWV and MRI-PWV can be accounted for by inaccuracies of currently used distance measurements.Methods: 114 study participants were recruited into one of 4 groups: Type 2 diabetes melltus (T2DM) with cardiovascular disease (CVD) (n=23), T2DM without CVD (n=41), CVD without T2DM (n=25) and a control group (n=25). All participants underwent cf-PWV, cardiac MRI and whole body MR angiography(WB-MRA). 90 study participants also underwent aortic PWV using MRI. cf-PWVEXT was performed using a SphygmoCor device (Atcor Medical, West Ryde, Australia). The true intra-arterial pathlength was measured using the WB-MRA and then used to recalculate the cf-PWVEXT to give a cf-PWVMRA.Results: Distance measurements were significantly lower on WB-MRA than on external tape measure (mean diff = -85.4 ± 54.0mm,p<0.001). MRI-PWV was significantly lower than cf-PWVEXT (MRI-PWV= 8.1 ± 2.9 vs. cf-PWVEXT =10.9 ± 2.7ms-1,p<0.001). When cf-PWV was recalculated using the inter-arterial distance from WB-MRA, this difference was significantly reduced but not lost (MRI-PWV=8.1 ± 2.9ms-1 vs. cf-PWVMRA 9.1 ± 2.1 ms-1, mean diff = -0.96±2.52ms-1,p=0.001). Recalculation of the PWV increased correlation with age and pulse pressure.Conclusion: Differences in cf-PWV and MRI PWV can be predominantly but not entirely explained by inaccuracies introduced by the use of simple surface measurements to represent the convoluted arterial path between the carotid and femoral arteries.

AB - Background: Carotid-femoral pulse wave velocity (cf-PWV) and aortic PWV measured using MRI (MRI-PWV) show good correlation, but with a significant and consistent bias across studies. The aim of the current study was to evaluate whether the differences between cf-PWV and MRI-PWV can be accounted for by inaccuracies of currently used distance measurements.Methods: 114 study participants were recruited into one of 4 groups: Type 2 diabetes melltus (T2DM) with cardiovascular disease (CVD) (n=23), T2DM without CVD (n=41), CVD without T2DM (n=25) and a control group (n=25). All participants underwent cf-PWV, cardiac MRI and whole body MR angiography(WB-MRA). 90 study participants also underwent aortic PWV using MRI. cf-PWVEXT was performed using a SphygmoCor device (Atcor Medical, West Ryde, Australia). The true intra-arterial pathlength was measured using the WB-MRA and then used to recalculate the cf-PWVEXT to give a cf-PWVMRA.Results: Distance measurements were significantly lower on WB-MRA than on external tape measure (mean diff = -85.4 ± 54.0mm,p<0.001). MRI-PWV was significantly lower than cf-PWVEXT (MRI-PWV= 8.1 ± 2.9 vs. cf-PWVEXT =10.9 ± 2.7ms-1,p<0.001). When cf-PWV was recalculated using the inter-arterial distance from WB-MRA, this difference was significantly reduced but not lost (MRI-PWV=8.1 ± 2.9ms-1 vs. cf-PWVMRA 9.1 ± 2.1 ms-1, mean diff = -0.96±2.52ms-1,p=0.001). Recalculation of the PWV increased correlation with age and pulse pressure.Conclusion: Differences in cf-PWV and MRI PWV can be predominantly but not entirely explained by inaccuracies introduced by the use of simple surface measurements to represent the convoluted arterial path between the carotid and femoral arteries.

KW - arteriosclerosis

KW - MRI

KW - PWV

KW - Diabetes

KW - Cardiovascular

U2 - 10.1186/s12872-017-0546-x

DO - 10.1186/s12872-017-0546-x

M3 - Article

C2 - 28486936

SN - 1471-2261

VL - 17

SP - 1

EP - 9

JO - BMC Cardiovascular Disorders

JF - BMC Cardiovascular Disorders

M1 - 118

ER -

Effects of inaccuracies in arterial path length measurement on differences in MRI and tonometry measured pulse wave velocity

Abstract

Keywords

UN SDGs

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Chest Heart & Stroke (Scotland) TASCFORCE

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