Effects of McN-A-343, a cholinomimetic drug, on endplate currents in the frog

K. Alkadhi, D. D. Branisteanu, E. G. Henderson, J. J. Lambert, R. L. Volle

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The muscarinic ganglion stimulating agent, McN-A-343 has unusual blocking actions on endplate currents (EPCs) at frog neuromuscular junctions. McN-A-343 caused depolarization by a curaresensitive process, blocked neuromuscular transmission, depressed EPCs and reduced the time for EPC decay. These results are explained best by a nicotinic agonist action of McN-A-343 on the acetylcholine receptor to cause ion flow and the blockade by McN-A-343 of the open ion channels. The actions of McN-A-343 are similar to those of decamethonium (C-10) described by others. Unlike C-10, however, McN-A-343 did not alter the exponential character of the EPC or alter the voltage dependency of the EPC. The prototypical nicotinic agonist, dimethylphenylpiperazinium had no effect on EPC parameters of endplate clamped at-90 mV.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume312
Issue number2
DOIs
Publication statusPublished - Jun 1980

Keywords

  • Depolarization blockade
  • Endplate currents
  • Ion channels
  • McN-A-343
  • Neuromuscular blockade

Fingerprint Dive into the research topics of 'Effects of McN-A-343, a cholinomimetic drug, on endplate currents in the frog'. Together they form a unique fingerprint.

  • Cite this