Effects of McN-A-343, a cholinomimetic drug, on endplate currents in the frog

K. Alkadhi; D. D. Branisteanu; E. G. Henderson; J. J. Lambert; R. L. Volle

doi:10.1007/BF00569719

Effects of McN-A-343, a cholinomimetic drug, on endplate currents in the frog

K. Alkadhi, D. D. Branisteanu, E. G. Henderson, J. J. Lambert, R. L. Volle

Systems Medicine

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The muscarinic ganglion stimulating agent, McN-A-343 has unusual blocking actions on endplate currents (EPCs) at frog neuromuscular junctions. McN-A-343 caused depolarization by a curaresensitive process, blocked neuromuscular transmission, depressed EPCs and reduced the time for EPC decay. These results are explained best by a nicotinic agonist action of McN-A-343 on the acetylcholine receptor to cause ion flow and the blockade by McN-A-343 of the open ion channels. The actions of McN-A-343 are similar to those of decamethonium (C-10) described by others. Unlike C-10, however, McN-A-343 did not alter the exponential character of the EPC or alter the voltage dependency of the EPC. The prototypical nicotinic agonist, dimethylphenylpiperazinium had no effect on EPC parameters of endplate clamped at-90 mV.

Original language	English
Pages (from-to)	117-121
Number of pages	5
Journal	Naunyn-Schmiedeberg's Archives of Pharmacology
Volume	312
Issue number	2
DOIs	https://doi.org/10.1007/BF00569719
Publication status	Published - Jun 1980

Keywords

Depolarization blockade
Endplate currents
Ion channels
McN-A-343
Neuromuscular blockade

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00569719

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@article{a321b8297d1745e6ac5580f47fd32e26,

title = "Effects of McN-A-343, a cholinomimetic drug, on endplate currents in the frog",

abstract = "The muscarinic ganglion stimulating agent, McN-A-343 has unusual blocking actions on endplate currents (EPCs) at frog neuromuscular junctions. McN-A-343 caused depolarization by a curaresensitive process, blocked neuromuscular transmission, depressed EPCs and reduced the time for EPC decay. These results are explained best by a nicotinic agonist action of McN-A-343 on the acetylcholine receptor to cause ion flow and the blockade by McN-A-343 of the open ion channels. The actions of McN-A-343 are similar to those of decamethonium (C-10) described by others. Unlike C-10, however, McN-A-343 did not alter the exponential character of the EPC or alter the voltage dependency of the EPC. The prototypical nicotinic agonist, dimethylphenylpiperazinium had no effect on EPC parameters of endplate clamped at-90 mV.",

keywords = "Depolarization blockade, Endplate currents, Ion channels, McN-A-343, Neuromuscular blockade",

author = "K. Alkadhi and Branisteanu, {D. D.} and Henderson, {E. G.} and Lambert, {J. J.} and Volle, {R. L.}",

year = "1980",

month = jun,

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T1 - Effects of McN-A-343, a cholinomimetic drug, on endplate currents in the frog

AU - Alkadhi, K.

AU - Branisteanu, D. D.

AU - Henderson, E. G.

AU - Lambert, J. J.

AU - Volle, R. L.

PY - 1980/6

Y1 - 1980/6

N2 - The muscarinic ganglion stimulating agent, McN-A-343 has unusual blocking actions on endplate currents (EPCs) at frog neuromuscular junctions. McN-A-343 caused depolarization by a curaresensitive process, blocked neuromuscular transmission, depressed EPCs and reduced the time for EPC decay. These results are explained best by a nicotinic agonist action of McN-A-343 on the acetylcholine receptor to cause ion flow and the blockade by McN-A-343 of the open ion channels. The actions of McN-A-343 are similar to those of decamethonium (C-10) described by others. Unlike C-10, however, McN-A-343 did not alter the exponential character of the EPC or alter the voltage dependency of the EPC. The prototypical nicotinic agonist, dimethylphenylpiperazinium had no effect on EPC parameters of endplate clamped at-90 mV.

AB - The muscarinic ganglion stimulating agent, McN-A-343 has unusual blocking actions on endplate currents (EPCs) at frog neuromuscular junctions. McN-A-343 caused depolarization by a curaresensitive process, blocked neuromuscular transmission, depressed EPCs and reduced the time for EPC decay. These results are explained best by a nicotinic agonist action of McN-A-343 on the acetylcholine receptor to cause ion flow and the blockade by McN-A-343 of the open ion channels. The actions of McN-A-343 are similar to those of decamethonium (C-10) described by others. Unlike C-10, however, McN-A-343 did not alter the exponential character of the EPC or alter the voltage dependency of the EPC. The prototypical nicotinic agonist, dimethylphenylpiperazinium had no effect on EPC parameters of endplate clamped at-90 mV.

KW - Depolarization blockade

KW - Endplate currents

KW - Ion channels

KW - McN-A-343

KW - Neuromuscular blockade

U2 - 10.1007/BF00569719

DO - 10.1007/BF00569719

M3 - Article

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AN - SCOPUS:0018876249

SN - 0028-1298

VL - 312

SP - 117

EP - 121

JO - Naunyn-Schmiedeberg's Archives of Pharmacology

JF - Naunyn-Schmiedeberg's Archives of Pharmacology

IS - 2

ER -

Effects of McN-A-343, a cholinomimetic drug, on endplate currents in the frog

Abstract

Keywords

ASJC Scopus subject areas

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