Effects of methylphenidate on spatial working memory and planning in healthy young adults

R. Elliott, B.J. Sahakian, K. Matthews, A. Bannerjea, J. Rimmer, T.W. Robbins

    Research output: Contribution to journalArticle

    305 Citations (Scopus)

    Abstract

    Previous studies of the effects of the psychomotor stimulant, methylphenidate, have concentrated on vigilance and reaction time tasks. In this study, the effects of methylphenidate on more complex aspects of cognition were studied using tasks from the CANTAB battery and related tests which have been shown to be sensitive to frontal lobe dysfunction. Twenty- eight young healthy men participated in a counterbalanced, double-blind, placebo-controlled study of the effects of methylphenidate. Cognitive assessment included tests of spatial working memory, planning, verbal fluency, attentional set-shifting and sustained attention. Methylphenidate had significant effects on performance of the tests of spatial working memory and planning but not on the attentional and fluency tests. When the drug was taken on the first test session, performance on the spatial tests was enhanced by the drug compared to placebo. However, when the drug wits taken second, performance accuracy was impaired whereas response latencies were decreased. These results are consistent with a hypothesis that methylphenidate influences performance in two conflicting ways; enhancing executive aspects of spatial function on novel tasks but impairing previously established performance. This pattern of effects is discussed within the framework of dual, interacting arousal mechanisms.
    Original languageEnglish
    Pages (from-to)196-206
    Number of pages11
    JournalPsychopharmacology
    Volume131
    Issue number2
    DOIs
    Publication statusPublished - 1997

    Keywords

    • Adult
    • Cognition
    • Double-Blind Method
    • Humans
    • Male
    • Memory
    • Methylphenidate
    • Spatial Behavior

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