Effects of poor glucose handling on arterial stiffness and left ventricular mass in normal children

F. Khan, H. Kerr, R. Ross, D. J. Newton, J. J. F. Belch

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    Aim. Cardiovascular risk factors can be present in children and young adults. We previously found abnormal microvascular function in children who had glucose intolerance and insulin resistance. The aim of the present study was to investigate whether they also have abnormalities in left ventricular mass (LVM) and arterial stiffness. Methods. We measured heart dimensions and LVM using echocardiography, and arterial stiffness using pulse wave analysis in 23 children with good glucose handling (post-feeding glucose: 3.9 to 5 mmol/L) and 21 with poor glucose handling (7.7 to 11.4 mmol/L). Results. The time to pulse reflection was slightly shorter in the poorer glucose handlers (mean±SD: 143±10 vs 153±20 ms, P=0.04), suggestive of increased arterial stiffness. Also in this group, there were significant relationships between intraventricular septal thickness, blood pressure and body mass index, but not in the normal glucose handlers. Conclusion. We have found that normal children who are in the lowest quintile of glucose tolerance in comparison with their peers are exhibiting the first signs of arterial stiffening. In addition, we have seen the beginnings of a relationship between blood pressure, body mass index and left ventricular enlargement in this group. While these changes may not yet be clinically significant, their emergence might be further evidence of early predisposition to cardiovascular disease.
    Original languageEnglish
    Pages (from-to)268-273
    Number of pages6
    JournalInternational Angiology
    Volume25
    Issue number3
    Publication statusPublished - 2006

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    Vascular Stiffness
    Glucose
    Body Mass Index
    Blood Pressure
    Pulse Wave Analysis
    Glucose Intolerance
    Echocardiography
    Pulse
    Insulin Resistance
    Young Adult
    Cardiovascular Diseases

    Cite this

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    title = "Effects of poor glucose handling on arterial stiffness and left ventricular mass in normal children",
    abstract = "Aim. Cardiovascular risk factors can be present in children and young adults. We previously found abnormal microvascular function in children who had glucose intolerance and insulin resistance. The aim of the present study was to investigate whether they also have abnormalities in left ventricular mass (LVM) and arterial stiffness. Methods. We measured heart dimensions and LVM using echocardiography, and arterial stiffness using pulse wave analysis in 23 children with good glucose handling (post-feeding glucose: 3.9 to 5 mmol/L) and 21 with poor glucose handling (7.7 to 11.4 mmol/L). Results. The time to pulse reflection was slightly shorter in the poorer glucose handlers (mean±SD: 143±10 vs 153±20 ms, P=0.04), suggestive of increased arterial stiffness. Also in this group, there were significant relationships between intraventricular septal thickness, blood pressure and body mass index, but not in the normal glucose handlers. Conclusion. We have found that normal children who are in the lowest quintile of glucose tolerance in comparison with their peers are exhibiting the first signs of arterial stiffening. In addition, we have seen the beginnings of a relationship between blood pressure, body mass index and left ventricular enlargement in this group. While these changes may not yet be clinically significant, their emergence might be further evidence of early predisposition to cardiovascular disease.",
    author = "F. Khan and H. Kerr and R. Ross and Newton, {D. J.} and Belch, {J. J. F.}",
    year = "2006",
    language = "English",
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    Effects of poor glucose handling on arterial stiffness and left ventricular mass in normal children. / Khan, F.; Kerr, H.; Ross, R.; Newton, D. J.; Belch, J. J. F.

    In: International Angiology, Vol. 25, No. 3, 2006, p. 268-273.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Effects of poor glucose handling on arterial stiffness and left ventricular mass in normal children

    AU - Khan, F.

    AU - Kerr, H.

    AU - Ross, R.

    AU - Newton, D. J.

    AU - Belch, J. J. F.

    PY - 2006

    Y1 - 2006

    N2 - Aim. Cardiovascular risk factors can be present in children and young adults. We previously found abnormal microvascular function in children who had glucose intolerance and insulin resistance. The aim of the present study was to investigate whether they also have abnormalities in left ventricular mass (LVM) and arterial stiffness. Methods. We measured heart dimensions and LVM using echocardiography, and arterial stiffness using pulse wave analysis in 23 children with good glucose handling (post-feeding glucose: 3.9 to 5 mmol/L) and 21 with poor glucose handling (7.7 to 11.4 mmol/L). Results. The time to pulse reflection was slightly shorter in the poorer glucose handlers (mean±SD: 143±10 vs 153±20 ms, P=0.04), suggestive of increased arterial stiffness. Also in this group, there were significant relationships between intraventricular septal thickness, blood pressure and body mass index, but not in the normal glucose handlers. Conclusion. We have found that normal children who are in the lowest quintile of glucose tolerance in comparison with their peers are exhibiting the first signs of arterial stiffening. In addition, we have seen the beginnings of a relationship between blood pressure, body mass index and left ventricular enlargement in this group. While these changes may not yet be clinically significant, their emergence might be further evidence of early predisposition to cardiovascular disease.

    AB - Aim. Cardiovascular risk factors can be present in children and young adults. We previously found abnormal microvascular function in children who had glucose intolerance and insulin resistance. The aim of the present study was to investigate whether they also have abnormalities in left ventricular mass (LVM) and arterial stiffness. Methods. We measured heart dimensions and LVM using echocardiography, and arterial stiffness using pulse wave analysis in 23 children with good glucose handling (post-feeding glucose: 3.9 to 5 mmol/L) and 21 with poor glucose handling (7.7 to 11.4 mmol/L). Results. The time to pulse reflection was slightly shorter in the poorer glucose handlers (mean±SD: 143±10 vs 153±20 ms, P=0.04), suggestive of increased arterial stiffness. Also in this group, there were significant relationships between intraventricular septal thickness, blood pressure and body mass index, but not in the normal glucose handlers. Conclusion. We have found that normal children who are in the lowest quintile of glucose tolerance in comparison with their peers are exhibiting the first signs of arterial stiffening. In addition, we have seen the beginnings of a relationship between blood pressure, body mass index and left ventricular enlargement in this group. While these changes may not yet be clinically significant, their emergence might be further evidence of early predisposition to cardiovascular disease.

    M3 - Article

    C2 - 16878075

    VL - 25

    SP - 268

    EP - 273

    JO - International Angiology

    JF - International Angiology

    SN - 0392-9590

    IS - 3

    ER -