Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of statins: rationale and design of the ODYSSEY COMBO I and II trials

Helen M. Colhoun; Jennifer G. Robinson; Michel Farnier; Bertrand Cariou; Dirk Blom; Dean J. Kereiakes; Christelle Lorenzato; Robert Pordy; Umesh Chaudhari

doi:10.1186/1471-2261-14-121

Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of statins: rationale and design of the ODYSSEY COMBO I and II trials

Helen M. Colhoun (Lead / Corresponding author)
, Jennifer G. Robinson
, Michel Farnier
, Bertrand Cariou
, Dirk Blom
, Dean J. Kereiakes
, Christelle Lorenzato
, Robert Pordy
, Umesh Chaudhari

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Alirocumab is a fully human monoclonal antibody to proprotein convertase subtilisin kexin type 9 (PCSK9) under investigation for treatment of hypercholesterolemia and reduction of cardiovascular events.

Original language	English
Pages (from-to)	121
Journal	BMC Cardiovascular Disorders
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/1471-2261-14-121
Publication status	Published - 2014

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Colhoun, H. M., Robinson, J. G., Farnier, M., Cariou, B., Blom, D., Kereiakes, D. J., Lorenzato, C., Pordy, R., & Chaudhari, U. (2014). Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of statins: rationale and design of the ODYSSEY COMBO I and II trials. BMC Cardiovascular Disorders, 14(1), 121. https://doi.org/10.1186/1471-2261-14-121

Colhoun, Helen M. ; Robinson, Jennifer G. ; Farnier, Michel et al. / Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of statins : rationale and design of the ODYSSEY COMBO I and II trials. In: BMC Cardiovascular Disorders. 2014 ; Vol. 14, No. 1. pp. 121.

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abstract = "Alirocumab is a fully human monoclonal antibody to proprotein convertase subtilisin kexin type 9 (PCSK9) under investigation for treatment of hypercholesterolemia and reduction of cardiovascular events.",

author = "Colhoun, \{Helen M.\} and Robinson, \{Jennifer G.\} and Michel Farnier and Bertrand Cariou and Dirk Blom and Kereiakes, \{Dean J.\} and Christelle Lorenzato and Robert Pordy and Umesh Chaudhari",

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Colhoun, HM, Robinson, JG, Farnier, M, Cariou, B, Blom, D, Kereiakes, DJ, Lorenzato, C, Pordy, R & Chaudhari, U 2014, 'Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of statins: rationale and design of the ODYSSEY COMBO I and II trials', BMC Cardiovascular Disorders, vol. 14, no. 1, pp. 121. https://doi.org/10.1186/1471-2261-14-121

Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of statins: rationale and design of the ODYSSEY COMBO I and II trials. / Colhoun, Helen M. (Lead / Corresponding author); Robinson, Jennifer G.; Farnier, Michel et al.
In: BMC Cardiovascular Disorders, Vol. 14, No. 1, 2014, p. 121.

Research output: Contribution to journal › Article › peer-review

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Colhoun HM, Robinson JG, Farnier M, Cariou B, Blom D, Kereiakes DJ et al. Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of statins: rationale and design of the ODYSSEY COMBO I and II trials. BMC Cardiovascular Disorders. 2014;14(1):121. doi: 10.1186/1471-2261-14-121